A meta-analysis of hypoxia inducible factor 1-alpha (HIF1A) gene polymorphisms: association with cancers

Anam, Md. T; Ishika, A; Hossain, Mohammad Bellal; Jesmin,

doi:10.1186/s40364-015-0054-z

Cited by 19 publications

(19 citation statements)

References 43 publications

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“…Genetic polymorphisms of HIF-1α or HIF-2α in human cancers have been found in previous studies (69)(70)(71)(72)(73)(74). The single nucleotide polymorphisms 1772C/T (rs11549465) and 1790 G/A (rs11549467) have been shown to be significantly associated with the overall risk of developing lung, breast, oral, prostate, cervical and renal cancers (69). Frank et al (70) demonstrated a significant association between rs2057482 in HIF-1α with the risk of rectal cancer.…”

Section: The Roles Of Hifs In Cancermentioning

confidence: 94%

Cancer stem cells and hypoxia-inducible factors (Review)

Tong

Liu

2018

Int J Oncol

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Cancer stem cells (CSCs), also known as tumor-initiating cells, are a subpopulation of tumor cells that exhibit properties similar to those of normal stem cells. Oxygen is an important regulator of cellular metabolism; hypoxia-inducible factors (HIFs) mediate metabolic switches in cells in hypoxic environments. Hypoxia clearly has the potential to exert a significant effect on the maintenance and evolution of CSCs. Both HIF‑1α and HIF‑2α may contribute to the regulation of cellular adaptation to hypoxia and resistance to cancer therapies. This review provides an overview of the roles of HIFs in CSCs. HIF‑1α and HIF‑2α have significant prognostic and predictive value in the clinic and the concept of personalized medicine should be applied in designing clinical trials for HIF inhibitors.

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Section: The Roles Of Hifs In Cancermentioning

confidence: 94%

Cancer stem cells and hypoxia-inducible factors (Review)

Tong

Liu

2018

Int J Oncol

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“…Similarly, miR-21, miR221, and miR222 family members function in oncogenesis [Hayes et al 2014]. In comparison, RUNX1 [Goyama et al 2013], TP53 [Beckerman and Prives 2010], BACH1 [Hira et al 2007], miR-193b [Yang et al 2014], and miR-124-3p ] act as tumor suppressors; and HIF1A [Anam et al 2015], PRDM14 [Nishikawa et al 2007], TRIM28 [Hatakeyama 2011], miR-15b-5p [Yang et al 2015], miR-30c-5p [Oksuz et al 2015], and miR-16-5p have been associated with various cancers.…”

Section: Regulatory Signatures: Reporter Tfs and Mirnasmentioning

confidence: 98%

Molecular signatures of ovarian diseases: Insights from network medicine perspective

Kori

Göv

Arğa

2016

Systems Biology in Reproductive Medicine

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Dysfunctions and disorders in the ovary lead to a host of diseases including ovarian cancer, ovarian endometriosis, and polycystic ovarian syndrome (PCOS). Understanding the molecular mechanisms behind ovarian diseases is a great challenge. In the present study, we performed a meta-analysis of transcriptome data for ovarian cancer, ovarian endometriosis, and PCOS, and integrated the information gained from statistical analysis with genome-scale biological networks (protein-protein interaction, transcriptional regulatory, and metabolic). Comparative and integrative analyses yielded reporter biomolecules (genes, proteins, metabolites, transcription factors, and micro-RNAs), and unique or common signatures at protein, metabolism, and transcription regulation levels, which might be beneficial to uncovering the underlying biological mechanisms behind the diseases. These signatures were mostly associated with formation or initiation of cancer development, and pointed out the potential tendency of PCOS and endometriosis to tumorigenesis. Molecules and pathways related to MAPK signaling, cell cycle, and apoptosis were the mutual determinants in the pathogenesis of all three diseases. To our knowledge, this is the first report that screens these diseases from a network medicine perspective. This study provides signatures which could be considered as potential therapeutic targets and/or as medical prognostic biomarkers in further experimental and clinical studies. Abbreviations DAVID: Database for Annotation, Visualization and Integrated Discovery; DEGs: differentially expressed genes; GEO: Gene Expression Omnibus; KEGG: Kyoto Encyclopedia of Genes and Genomes; LIMMA: Linear Models for Microarray Data; MBRole: Metabolite Biological Role; miRNA: micro-RNA; PCOS: polycystic ovarian syndrome; PPI: protein-protein interaction; RMA: Robust Multi-Array Average; TF: transcription factor.

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“…One of them is the VEGF involved in angiogenesis. Studying samples of the tumors of head and neck squamous cell carcinoma patients having the rare homozygous allele of the 1771C>T SNP revealed increased number of micro‐vessels . Moreover, a synergistic effect was found between HIF‐1α gene polymorphisms and environmental factors such as tobacco smoking and betel nut consumption …”

Section: Discussionmentioning

confidence: 98%

“…Both are located in exon 12 in the ODD domain of the HIF‐1 gene, and they are related to the increased transactivation capacity of HIF‐1α gene . Therefore, both SNPs are usually studied together to investigate their role in the etiology of various types of cancer and other diseases such as chronic obstructive pulmonary disease and osteonecrosis …”

Section: Discussionmentioning

confidence: 99%

A Genetic Association Study of a Specific Gene and Severe Form of Resorption in the Edentulous Mandible in the Egyptian Population

Emam

Amin

Issa

et al. 2019

Journal of Prosthodontics

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Purpose To investigate for the first time in Egypt and the Middle East the relationship between a specific gene and the presence of severely resorbed edentulous mandibular ridges in a sample of the Egyptian population. Materials and Methods The study was conducted on 50 subjects divided into case and control groups according to the residual ridge height. Saliva was used as a convenient source of DNA in the dental clinic. A certain genetic variation (1772C>T) in an important gene related to bone healing (hypoxia‐inducible factor‐1 alpha [HIF1‐α] gene) was selected. The genetic variation 1772C>T is a single nucleotide polymorphism (SNP) that occurs when corresponding sequences of DNA from different individuals differ at one base. Then, we have 2 forms of the gene (2 alleles): C and T. SNPs typically have 3 genotypes; in this study, they are the CC, CT, and TT genotypes. Polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) was the method performed for genotyping. The statistical significance of the results was evaluated by the Chi‐square test and Fisher Exact test. Results A statistically significant difference in the distribution of the TT genotype between both groups was detected with p‐value = 0.049. There was also a difference in the distribution of the CC and CT genotypes, but it was not statistically significant, since the p‐values were 0.733 and 0.145, respectively. The T alleles were more abundant in the case group, while the control group showed more frequency of the C allele with no statistical significance. Conclusion The TT genotype of the 1772C>T polymorphism of HIF1‐α gene is related to the presence of severely atrophied residual ridges in completely edentulous Egyptians. This can be used as a marker to predict the future condition of the ridge using saliva samples. Further studies on larger scale are recommended.

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A meta-analysis of hypoxia inducible factor 1-alpha (HIF1A) gene polymorphisms: association with cancers

Cited by 19 publications

References 43 publications

Cancer stem cells and hypoxia-inducible factors (Review)

Cancer stem cells and hypoxia-inducible factors (Review)

Molecular signatures of ovarian diseases: Insights from network medicine perspective

A Genetic Association Study of a Specific Gene and Severe Form of Resorption in the Edentulous Mandible in the Egyptian Population

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