A Meta-Analysis of How Nonalcoholic Fatty Liver Disease Affect Antiviral Treatment of Patients with e Antigen-Positive Chronic Hepatitis B

Chen, Yandong; Liu, Qiang; Han, Jing; Gao, Siyu; Xiao, Qian; Huang, Xiaoli; Lu, Lu; Zhou, Xiaolin

doi:10.1155/2022/4774195

Emergency Medicine International

2022

DOI: 10.1155/2022/4774195

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A Meta-Analysis of How Nonalcoholic Fatty Liver Disease Affect Antiviral Treatment of Patients with e Antigen-Positive Chronic Hepatitis B

Yandong Chen

Qiang Liu

Jing Han

et al.

Abstract: Background. Nonalcoholic fatty liver disease (NAFLD) and chronic hepatitis B (CHB) are both the most common underlying diseases leading to cirrhosis and hepatocellular carcinoma, and NAFLD and HBV infection are the first and second leading causes of chronic liver disease in China. However, there are still a lot of controversies about whether the combined presence of CHB and NAFLD will affect the course or outcome of liver disease together with HBV, and how the two affect each other. Objective. To investigate t… Show more

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Cited by 3 publications

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“…Tis article has been retracted by Hindawi following an investigation undertaken by the publisher [1]. Tis investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process:…”

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confidence: 99%

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Peer-review manipulation …”

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Retracted: A Meta-Analysis of How Nonalcoholic Fatty Liver Disease Affect Antiviral Treatment of Patients with e Antigen-Positive Chronic Hepatitis B

2023

Emergency Medicine International

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Retracted: A Meta-Analysis of How Nonalcoholic Fatty Liver Disease Affect Antiviral Treatment of Patients with e Antigen-Positive Chronic Hepatitis B

2023

Emergency Medicine International

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Is nonalcoholic fatty liver disease a predictor of treatment response in chronic hepatitis B?

Liu

Chen

2023

Journal of Medical Virology

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Is nonalcoholic fatty liver disease a predictor of treatment response in chronic hepatitis B? Dear Editor, We read with great interest the recent article by Tang et al. on the impact of status changes in nonalcoholic fatty liver disease (NAFLD) on the efficacy of antiviral therapy in HBeAg-positive patients with chronic hepatitis B (CHB). 1 New-onset and sustained NAFLD failed to change the virological response (VR) but altered the biochemical response (BR) rate and fibrosis improvement compared to the sustained non-NAFLD group. 1 These findings add new and compelling evidence to the paradoxical relationship between NAFLD and CHB. However, some questions still need to be addressed, namely whether the presence of NAFLD in CHB patients may be used as a predictor for treatment response, and what are the influencing factors and determinants in this regard. As noted by the authors, there was significant heterogeneity in the effect of NAFLD on response to antiviral therapy among patients with CHB. A recent meta-analysis pooled all previous data suggesting that NAFLD significantly attenuated treatment efficacy in HBeAg-positive CHB patients, including VR, BR, and HBeAg conversion as measured. 2 A question worth considering is the potential role of HBeAg positivity in the impact of NAFLD on patients with CHB receiving antiviral therapy. A study concluded that serum HBeAg positivity and NAFLD may jointly contribute to persistently elevated alanine aminotransferase levels during treatment. 3 Similarly, Zhang et al. recently determined that HBeAg positivity was associated with delayed complete VR. 4HBeAg positivity was negatively associated with the presence of hepatic steatosis in two large meta-analyses, and both pooled results found that NAFLD was not associated with fibrosis progression in patients with CHB, although these studies did not summarize the effect of NAFLD on fibrosis improvement in CHB patients receiving antiviral therapy. 5,6 Therefore, it is conceivable that HBeAg seropositivity may have a confounding role in the effect of NAFLD on the efficacy of antiviral therapy in CHB patients, and exploring the effect of NAFLD in HBeAgnegative patients may help to further clarify these effects.Another influencing factor may be the concurrent metabolic syndrome. The development of steatohepatitis in patients with CHB is strongly associated with the coexisting metabolic syndrome rather than with viral factors. 7 The BR during antiviral therapy in CHB patients can be influenced by other metabolic comorbidities, such as obesity and diabetes. 8 These important confounders were not discussed in detail and may have potentially impacted the outcomes.Finally, the severity of NAFLD per se may necessitate further stratified analysis. A study similarly revealed that NAFLD could reduce the long-term BR rate in HBeAg-positive CHB patients, an association that increased with the severity of fatty liver. 9 Interestingly, in extremely severe cases of hepatic steatosis, this association was no longer observed. 10 These results indi...

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Predictors of Hepatocytes Cytolysis of Insulin Resistant Rats Under Conditions of Pre- And Postnatal Iodine Deficiency

Stetseviat¹,

Voronych-Semchenko²,

Bahrii³

et al. 2023

Fiziol Zh

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Carbohydrate metabolism markers, thyroid profile indexes, transaminase activity and structural features of liver were studied, taking into account sexual dimorphism, in rats which were keeping on a high-fructose diet under conditions of adequate iodine supply and pre- and postnatal iodine deficiency. It was found that under fructose loading of animals with iodine deficiency the risk of insulin resistance (IR) development increases (HOMA-IR index in insulin-resistant male rats under conditions of pre- and postnatal iodine deficiency increases respectively by 22 and 13% compared to the data in animals that received a high-carbohydrate diet and adequate iodine supply). It is important, that in males and females with IR, the secretion of free triiodothyronine decreased by 36 and 40%, thyroid-stimulating hormone – by 28 and 34%, respectively, compared to the data of intact animals. The development of IR was accompanied by the activation of aminotransferases in blood serum (more in males). In particular, in male rats with IR under conditions of pre- and postnatal iodine deficiency, the activity of aspartate aminotransferase increased by 2.7 and 2.4 times, alanine aminotransferase – by 3.9 and 2.7 times, respectively, which led to a decrease of the de-Ritis index (more significantly against the background of prenatal iodine deficiency – by 25%) in relation to the data in animals that were on a standard diet. The activity of aminotransferases in rats with IR under conditions of iodine deprivation was higher than in animals with isolated iodine deficiency – by 11-56% and IR – by 13-47 %. In animals with IR, the presence of binucleated hepatocytes with a diffuse decrease in the number of glycogen granules in them and accumulation of glycoproteins in the wall of liver vessels were found. The foci of fatty dystrophy and pronounced zonal character of dystrophic processes in hepatocytes were identified in females, diffuse dystrophy prevailed in males. In the cytoplasm of hepatocytes of animals with IR under conditions of prenatal iodine deficiency, the lightening and the granularity, single granules of glycogen were observed. Under these conditions, the average perimeter (by 74%) and area (by three times) of hepatocytes, the average area of nucleus (by 3.1 times), the average perimeter (by 50%) and area (by 66%) of the nucleolus were increased compared to the control values. The structural changes were consistent with an increase of the transaminase activity. Thus, fructose loading and the development of IR acts as a trigger for cytolysis of hepatocytes, which increases under conditions of iodine deficiency, especially prenatal.

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A Meta-Analysis of How Nonalcoholic Fatty Liver Disease Affect Antiviral Treatment of Patients with e Antigen-Positive Chronic Hepatitis B

Cited by 3 publications

References 13 publications

Retracted: A Meta-Analysis of How Nonalcoholic Fatty Liver Disease Affect Antiviral Treatment of Patients with e Antigen-Positive Chronic Hepatitis B

Retracted: A Meta-Analysis of How Nonalcoholic Fatty Liver Disease Affect Antiviral Treatment of Patients with e Antigen-Positive Chronic Hepatitis B

Is nonalcoholic fatty liver disease a predictor of treatment response in chronic hepatitis B?

Predictors of Hepatocytes Cytolysis of Insulin Resistant Rats Under Conditions of Pre- And Postnatal Iodine Deficiency

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