A Meta Analysis of Different Herbs (Leaves, Roots, Stems) Used in Treatment of Cancer Cells

Patterns of chromatin accessibility, which are in turn altered by epigenetic mechanisms, are responsible for determining the interactions that take place between transcription machinery, genes, and the cis-regulatory elements of those genes. Mutations that interfere with epigenetic processes frequently have the unfortunate side effect of causing cancer. Since these mutations can be undone, numerous anticancer treatments that target epigenetic pathways are now being developed and evaluated. (Cancer) is becoming more and more common everywhere. This decline in clinical outcomes is a result of a number of factors, including late diagnosis, a lack of efficient treatments for particular cancer subtypes, and drug resistance. Treatment resistance and stemness traits have been recognised as markers of this disease, and it has been demonstrated that epigenetic changes play a role in the process of cancer growth. Understanding these alterations and how they impact cancer carcinogenesis treatment is challenging but crucial. However, it may be able to provide the special knowledge needed to use these alterations as potential diagnostic, prognostic, therapeutic agents, and predictors of treatment efficacy. This underlines the importance of continued research to advance our knowledge of cancer carcinogenesis and epigenetics and help us overcome these challenges. This review aims to provide an overview of the state of the art in epigenetics research for cancer detection and treatment and to stimulate discussion on this subject.

Section: Pancreatic Ductal Adenocarcinoma: the Emerging Role Of Epige...mentioning

confidence: 99%

Herbal used as Epigenetic for Cancer Treatment

Navadiya¹,

Goti²,

Raloliya³

et al. 2023

“…When AMPK is turned on, it stimulates the production of PGC1 and other genes involved in regulating mitochondrial biogenesis and oxidative metabolism. Sirt1 regulates PGC1 through posttranslational modification [43][44]. There are two ways in which AMPK activates Sirt1: by regulating NAMPT, the ratelimiting enzyme in nicotinamide adenine dinucleotide production, or by regulating the ratio of NAD+ to nicotinamide adenine dinucleotide hydroxide.…”

Section: Gallic Acidmentioning

confidence: 99%

Combine Therapy of Gallic Acid and Allicin in Management of Diabetes

Kumar¹,

Gardner-Sood²,

Rana³

et al. 2023

Type 2 diabetes, also known (DM) is a metabolic disorder with a high mortality and disability incidence. The development and activation of oxidative stress (OS) are crucial to the pathogenic development of DM. Pathophysiological evidence suggests that OS contributes to the onset and progression of DM through its association with hyperglycemia, resistance to insulin, and inflammation. It's worth noting that more and more studies are investigating the benefits of natural antioxidants for managing DM. Many different types of culinary and herbal plants contain the antioxidant and anti-inflammatory compounds gallic acid (GA) and allicin, respectively. The synthesis of advanced glycation end products (AGEs) is inhibited, fat is stored less, blood sugar and weight are improved, and the body produces fewer AGEs, according to the study's authors. Inhibition of RAGEs and prevention of AGE activity following treatment with GA and allicin resulted in reduced oxidative stress and enhanced insulin secretion. The goals of this article are to (1) provide evidence that GA and allicin may be effective antihyperglycemic treatments for DM and its complications and (2) provide a comprehensive review of the current state of knowledge regarding studies examining the role of oleic acid in this disease.

“…To put it simply, this is the answer. This proton gradient is said to be the source of the energy that drives ATP synthase to create ATP, as stated in references [18], and [19], Within the context of this process, it is worth noting that only a limited quantity of oxygen molecules undergo the transformation into reactive oxygen species (ROS), comprising O2−. In diabetic cells, on the other hand, the breakdown of glucose in the tricarboxylic acid cycle (TCA cycle) requires an excess of glucose.…”

Section: Introductionmentioning

confidence: 99%

Diabetic Retinopathy: Current Understanding, Mechanisms and Treatment Strategies

Amjad,

Gupta,

Anamika

et al. 2024

Researchers have been assuming about the possible connection between the eye and the central nervous system (CNS) for a considerable amount of time. This is primarily due to the fact that the eye is considered to be an extension of the brain, which is a reasonable assumption. The neural tube is the beginning of both structures, and neurons are the building blocks of both structures. Retinal ganglionic cells, also known as RGCs, are a specific type of cell that are found in the retina. These cells are responsible for receiving light signals from the environment around them and then transmitting them to photoreceptors, which are involved in the process of vision. The retina, which is found inside the eye, is responsible for converting light into electrical impulses, which are then sent to the brain through the optic nerve. Glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy are only few of the eye illnesses that can be caused by chronic progressive neurodegeneration of the retina, which is more prevalent in older people. It is the elderly who are most likely to be affected by these eye disorders; nevertheless, younger people are also susceptible to them and may experience permanent vision loss or a reduction in their eyesight. In most cases, neurodegenerative disorders that are characteristic of CSN are characterised by common symptoms and a cause that is only partially understood. Although certain risk factors have been identified, they do not account for all instances. On the other hand, according to a number of studies, several illnesses of the central nervous system (CNS), such as Alzheimer's disease (AD) and Parkinson's disease (PD), which are responsible for a significant amount of mortality and morbidity on a global scale, display distinctive alterations at the ocular level. It is helpful to be aware of potential linkages in order to have a better understanding of the mechanics on which onset occurs. In addition, experts have not yet reached a consensus regarding the factors that are responsible for these various disorders. In this overview, the symptoms of ocular illnesses are discussed in detail, with a particular focus on the interaction between the brain and the eye. At some point in the future, a more in-depth understanding could be of assistance in the development of innovative treatments that could help reduce or prevent blindness and improve quality of life.