A meta-analysis of clinical predictors for renal recovery and overall mortality in acute kidney injury requiring continuous renal replacement therapy

Hansrivijit, Panupong; Yarlagadda, Keerthi; Puthenpura, Max; Ghahramani, Nasrollah; Vaitla, Pradeep; Cheungpasitporn, Wisit

doi:10.1016/j.jcrc.2020.07.012

Cited by 18 publications

(19 citation statements)

References 41 publications

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“…The meta-analysis results of this study showed that older age, lower BMI, higher APACHE II, and SOFA scores, lower systolic BP and diastolic BP, lower serum creatinine level, and higher serum sodium level increased the risk of in-hospital mortality among critically ill patients who required CRRT. Unsurprisingly, our review showed that older patients were more at risk of in-hospital mortality, which was in line with previous reviews [5,15]. Older adults tend to be vulnerable to AKI, as they often have complex and multiple comorbidities, polypharmacy, and age-related structural and functional changes in their kidneys [26].…”

Section: Discussionsupporting

confidence: 90%

“…AKI is associated with significantly high hospital mortality and morbidity among critically ill patients [2,3]. The prevalence of AKI has been reported for approximately 30-60% critically ill patients in intensive care units (ICUs) [4,5]. Therefore, renal replacement therapy is vital for critically ill patients with AKI to provide supportive management in critical care settings aimed at speeding up renal recovery and preventing adverse events [6].…”

Section: Introductionmentioning

confidence: 99%

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Factors Associated with In-Hospital Mortality after Continuous Renal Replacement Therapy for Critically Ill Patients: A Systematic Review and Meta-Analysis

Lee

Son

2020

IJERPH

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Continuous renal replacement therapy (CRRT) is a broadly-accepted treatment for critically ill patients with acute kidney injury to optimize fluid and electrolyte management. Despite intensive dialysis care, there is a high mortality rate among these patients. There is uncertainty regarding the factors associated with in-hospital mortality among patients requiring CRRT. This review evaluates how various risk factors influence the in-hospital mortality of critically ill patients who require CRRT. Five databases were surveyed to gather relevant publications up to 30 June 2020. We identified 752 works, of which we retrieved 38 in full text. Finally, six cohort studies that evaluated 1190 patients were eligible. The in-hospital mortality rate in these studies ranged from 38.6 to 62.4%. Our meta-analysis results showed that older age, lower body mass index, higher APACHE II and SOFA scores, lower systolic and diastolic blood pressure, decreased serum creatinine level, and increased serum sodium level were significantly associated with increased in-hospital mortality in critically ill patients who received CRRT. These results suggest that there are multiple modifiable factors that influence the risk of in-hospital mortality in critically ill patients undergoing CRRT. Further, healthcare professionals should take more care when CRRT is performed on older adults.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Factors Associated with In-Hospital Mortality after Continuous Renal Replacement Therapy for Critically Ill Patients: A Systematic Review and Meta-Analysis

Lee

Son

2020

IJERPH

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“…Similar results were shown among patients with AKI in the United Kingdom [15]. A recent meta-analysis of 11 studies (n = 16,948) in patients with AKI on continuous kidney replacement therapy (CKRT) showed a correlation between increasing age and mortality with an odds ratio (OR) 1.023 (CI 1.006-1.04) [18].…”

Section: Introductionsupporting

confidence: 53%

“…Despite that, no tool was validated as an AKI-D outcome prediction model. While a model consisting of four variables, including pre-admission hemoglobin level was reported to have a moderate ability to identify the probability of kidney recovery in patients with AKI [16], high pre-AKI-D level of proteinuria and increased serum creatinine level at CKRT initiation were demonstrated to be an independent risk factor for non-recovery of patients with AKI-D [18].…”

Section: Laboratory Parametersmentioning

confidence: 99%

“…The effects of the severity of acute disease and high illness severity (Charlson comorbidity index and APACHE II score) associated with AKI have been assessed in sveral studies and showed that the less severity of the acute diseases was a predictor for kidney recovery and less mortality after the onset of AKI-D [15,[18][19][20][21][22].…”

Section: Co-morbidities Severity Of Acute Diseasementioning

confidence: 99%

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Determinants of Outcomes of Acute Kidney Injury: Clinical Predictors and Beyond

Abdel‐Rahman

Turgut

Gautam

et al. 2021

JCM

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Acute kidney injury (AKI) is a common clinical syndrome characterized by rapid impairment of kidney function. The incidence of AKI and its severe form AKI requiring dialysis (AKI-D) has been increasing over the years. AKI etiology may be multifactorial and is substantially associated with increased morbidity and mortality. The outcome of AKI-D can vary from partial or complete recovery to transitioning to chronic kidney disease, end stage kidney disease, or even death. Predicting outcomes of patients with AKI is crucial as it may allow clinicians to guide policy regarding adequate management of this problem and offer the best long-term options to their patients in advance. In this manuscript, we will review the current evidence regarding the determinants of AKI outcomes, focusing on AKI-D.

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Factors associated with successful liberation from continuous renal replacement therapy in children and young adults: analysis of the worldwide exploration of renal replacement outcomes collaborative in Kidney Disease Registry

Stenson,

Alhamoud,

Alobaidi

et al. 2024

Intensive Care Med

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A meta-analysis of clinical predictors for renal recovery and overall mortality in acute kidney injury requiring continuous renal replacement therapy

Cited by 18 publications

References 41 publications

Factors Associated with In-Hospital Mortality after Continuous Renal Replacement Therapy for Critically Ill Patients: A Systematic Review and Meta-Analysis

Factors Associated with In-Hospital Mortality after Continuous Renal Replacement Therapy for Critically Ill Patients: A Systematic Review and Meta-Analysis

Determinants of Outcomes of Acute Kidney Injury: Clinical Predictors and Beyond

Factors associated with successful liberation from continuous renal replacement therapy in children and young adults: analysis of the worldwide exploration of renal replacement outcomes collaborative in Kidney Disease Registry

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