A meta-analysis of association between serum iron levels and lung cancer risk

Chen, Huafei; Wu, Lei; Li, Xiaofeng; Zhu, You‐cai; Wang, Wenxian; Xu, C.; Xie, Dong-fang; Huang, Jian; Du, Kun

doi:10.14715/cmb/2018.64.13.7

Cited by 14 publications

(9 citation statements)

References 12 publications

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“…Some previous studies had been published to explore serum element levels and lung cancer risk. Chen et al performed a meta-analysis with 13 publications to assess the association between serum iron levels and lung cancer risk [48]. The authors concluded that serum iron levels had no effect on the risk of lung cancer.…”

Section: Discussionmentioning

confidence: 99%

Association between serum zinc levels and lung cancer: a meta-analysis of observational studies

Wang

Sun

et al. 2019

World J Surg Onc

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Background Inconsistent results according to numerous studies that had investigated the association between serum zinc levels and lung cancer risk were reported. The aim of this study was to explore whether serum zinc levels were lower in lung cancer patients than that in controls. Methods We systematically retrieved the databases of PubMed, Wanfang, Cochrane, ScienceDirect website, CNKI, and SinoMed databases for comprehensive relevant studies published before December 2018 and conducted a meta-analysis. Standard mean differences (SMD) were pooled using a random effects model. Results Thirty-two articles were eligible to investigate the correlation between serum zinc levels and lung cancer risk, involving 2894 cases and 9419 controls. The pooled results showed sufficient evidence approving the association between serum zinc levels and lung cancer risk. And the serum zinc levels in lung cancer were significantly lower than that in controls (summary SMD = − 0.88, 95% confidence interval (CI) = − 0.94, − 0.82). Meanwhile, consistent results were obtained both in European populations and Asian populations. No publication bias was detected in our analysis. Conclusions The present meta-analysis suggested that serum zinc levels were significantly lower in lung cancer patients than that in controls.

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Section: Discussionmentioning

confidence: 99%

Association between serum zinc levels and lung cancer: a meta-analysis of observational studies

Wang

Sun

et al. 2019

World J Surg Onc

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“…A randomized trial of 1277 individuals with peripheral arterial disease (636 in iron reduction group through venesection and 641 in control group) found that in the iron reduction group, who received regular phlebotomy, the risk of overall cancer, cancer-specific mortality and all-cause mortality was lower than in the control group after 4.5 years of follow-up [4]. However, findings of observational studies are inconsistent or scarce concerning the effects of iron status on individual cancers, such as colorectal, breast and oesophagal cancer [5][6][7][8][9][10][11]. Consequently, whether iron status (which is routinely measured in clinical practice as serum iron, transferrin saturation, ferritin and transferrin) plays a role in the development of site-specific cancer remains inconclusive.…”

Section: Introductionmentioning

confidence: 99%

Iron Status and Cancer Risk in UK Biobank: A Two-Sample Mendelian Randomization Study

et al. 2020

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We conducted a two-sample Mendelian randomization study to explore the associations of iron status with overall cancer and 22 site-specific cancers. Single-nucleotide polymorphisms for iron status were obtained from a genome-wide association study of 48,972 European-descent individuals. Summary-level data for breast and other cancers were obtained from the Breast Cancer Association Consortium and UK Biobank. Genetically predicted iron status was positively associated with liver cancer and inversely associated with brain cancer but not associated with overall cancer or the other 20 studied cancer sites at p < 0.05. The odds ratios of liver cancer were 2.45 (95% CI, 0.81, 7.45; p = 0.11), 2.11 (1.16, 3.83; p = 0.02), 10.89 (2.44, 48.59; p = 0.002) and 0.30 (0.17, 0.53; p = 2 × 10−5) for one standard deviation increment of serum iron, transferrin saturation, ferritin and transferrin levels, respectively. For brain cancer, the corresponding odds ratios were 0.69 (0.48, 1.00; p = 0.05), 0.75 (0.59, 0.97; p = 0.03), 0.41 (0.20, 0.88; p = 0.02) and 1.49 (1.04, 2.14; p = 0.03). Genetically high iron status was positively associated with liver cancer and inversely associated with brain cancer.

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“…Transferrin saturation also exceeded 20−50%, the limit commonly used to diagnose iron overload (Elsayed et al, 2016;Sebastiani et al, 2012). In addition to being a consequence of disorders related to iron metabolism or recurrent blood transfusions, an elevated serum iron level is also considered a risk factor for increased mortality in patients with sepsis (Lan et al, 2018), pre-eclampsia in pregnant women (Liu et al, 2019) and several types of cancers, such as liver, lung and breast (Chen et al, 2018;Wen et al, 2014). In this regard, the present experimental animal model of parenteral administration is commonly used to simulate a chronic state of iron overload in humans, regardless of the aetiology.…”

Section: Discussionmentioning

confidence: 99%

Moderate‐intensity aerobic training reduces cardiac damage attributable to experimental iron overload in rats

Ávila

Rossi

Carvalho

et al. 2021

Experimental Physiology

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Iron is an essential micronutrient for several life processes, but its excess can damage organs owing to oxidative stress, with cardiomyopathy being the leading cause of death in iron-overloaded patients. Although exercise has long been considered as a cardioprotective tool, its effects on iron overload are not known. This study was designed to investigate the effects of moderate-intensity aerobic training in rats previously submitted to chronic iron overload. Wistar rats received i.p. injections of iron dextran (100 mg/kg, 5 days/week for 4 weeks); thereafter, the rats were kept sedentary or exercised (60 min/day, progressive aerobic training, 60-70% of maximal speed, 5 days/week on a treadmill) for 8 weeks. At the end of the experimental period, haemodynamics were recorded and blood samples, livers and hearts harvested. Myocardial mechanics of papillary muscles were assessed in vitro, and cardiac remodelling was evaluated by histology and immunoblotting. Iron overload led to liver iron deposition, liver fibrosis and increased serum alanine aminotransferase and aspartate aminotransferase. Moreover, cardiac iron accumulation was accompanied by impaired myocardial mechanics, increased cardiac collagen type I and lipid peroxidation (TBARS), and release of creatine phosphokinase-MB to the serum. Although exercise did not influence iron levels, tissue injury markers were significantly reduced. Likewise, myocardial contractility and inotropic responsiveness were improved in exercised rats, in association with an increase in the endogenous antioxidant enzyme catalase.In conclusion, moderate-intensity aerobic exercise was associated with attenuated oxidative stress and cardiac damage in a rodent model of iron overload, thereby suggesting its potential role as a non-pharmacological adjuvant therapy for ironoverload cardiomyopathy.

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A meta-analysis of association between serum iron levels and lung cancer risk

Cited by 14 publications

References 12 publications

Association between serum zinc levels and lung cancer: a meta-analysis of observational studies

Association between serum zinc levels and lung cancer: a meta-analysis of observational studies

Iron Status and Cancer Risk in UK Biobank: A Two-Sample Mendelian Randomization Study

Moderate‐intensity aerobic training reduces cardiac damage attributable to experimental iron overload in rats

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