A Meta-Analysis of Aerobic Exercise Interventions for Women With Breast Cancer

Kim, Chun‐Ja; Kang, Duck Hee; Park, Jee Won

doi:10.1177/0193945908328473

Cited by 67 publications

(47 citation statements)

References 56 publications

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“…Emphasis is needed on higher intensity exercise particularly resistance training, as aerobic exercise has shown to improve body composition (that is, decrease FM) but not LBM gain. [35][36][37] During follow-up, a number of participants reported their barrier to resistance type exercises included nausea, persistent fatigue or weakness. Telephone-delivered exercise counselling did not increase PAL amongst the intervention group as expected.…”

Section: Discussionmentioning

confidence: 99%

Telephone-delivered nutrition and exercise counselling after auto-SCT: a pilot, randomised controlled trial

Hung

Bauer

Horsely

et al. 2014

Bone Marrow Transplant

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Adverse changes in nutrition-related outcomes including quality of life (QoL) occur after PBSC transplantation. This randomised controlled trial aims to evaluate the impact of nutrition and exercise counselling provided at hospital discharge on nutritional status, body composition and QoL post transplantation. Usual care (UC) (n = 19) received no intervention after discharge; extended care (EC) (n = 18) received fortnightly telephone counselling from a dietitian and exercise physiologist up to 100 days post transplantation. Nutritional status (patient-generated subjective global assessment, and diet history), QoL (EORTC QLQ-C30 version 3) and body composition (air displacement plethysmography) were assessed at pre-admission, discharge and 100 days post transplantation. Intervention groups were compared using two-sample t-tests of changes in the outcomes; results were adjusted using analysis of covariance. EC exhibited clinically important but not statistically significant increases in protein intake (14.7 g; confidence interval (CI) 95% − 6.5, 35.9, P = 0.165), cognitive functioning (7.2; CI 95% − 7.9, 22.2, P = 0.337) and social functioning (16.5; CI 95% − 7.3, 40.3, P = 0.165) compared with UC. Relative to pre-admission, EC experienced less weight loss than UC (−3.3 kg; CI 95% − 6.7, 0.2, P = 0.062). Physical activity was not significantly different between the groups. Ongoing nutrition and exercise counselling may prevent further weight loss and improve dietary intake and certain QoL components in autologous PBSC transplantation patients following hospitalisation.

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Section: Discussionmentioning

confidence: 99%

Telephone-delivered nutrition and exercise counselling after auto-SCT: a pilot, randomised controlled trial

Hung

Bauer

Horsely

et al. 2014

Bone Marrow Transplant

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“…Kim and colleagues performed a meta-analysis of aerobic exercise on body composition in breast cancer patients and included ten trials of exercise interventions in women during (8 trials) or at completion (2 trials) of adjuvant treatment [63] . The study groups participated in median of three sessions per week, 30-40 min each of moderate exercise and were found to have decreased percent body fat, without significant change in weight or lean body mass.…”

Section: Potential Interventions To Avoid Weight Gainmentioning

confidence: 99%

“…Participation in regular exercise contributed to weight loss and enhanced QoL, mood and energy level. In this review it was suggested, based on the analyses by Kim and De Backer, that in order to decrease percent body fat, aerobic exercise would be favored over resistance training [63,64] . Interventions for weight management or loss over the past twenty years were summarized by Demark-Wahnefried [66] .…”

Section: Potential Interventions To Avoid Weight Gainmentioning

confidence: 99%

“…Ligibel and co-investigators studied overweight (BMI > 25 kg/m 2 ) but nondiabetic, breast cancer patients who were at least 3 mo beyond the completion of treatment [62] . After 16 wk, fasting insulin levels decreased by 28% and hip circumference decreased in the exercise group compared to those receiving usual care, but there was not a significant decrease in WHR and no significant weight loss.Kim and colleagues performed a meta-analysis of aerobic exercise on body composition in breast cancer patients and included ten trials of exercise interventions in women during (8 trials) or at completion (2 trials) of adjuvant treatment [63] . The study groups participated in median of three sessions per week, 30-40 min each of moderate exercise and were found to have decreased percent body fat, without significant change in weight or lean body mass.…”

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confidence: 99%

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Weight gain following breast cancer diagnosis: Implication and proposed mechanisms

Makari-Judson

Braun

Jerry

et al. 2014

WJCO

125

106

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Weight gain occurs in the majority of women following breast cancer treatment. An overview of studies describing weight gain amongst women treated with early to modern chemotherapy regimens is included. Populations at higher risk include women who are younger, closer to ideal body weight and who have been treated with chemotherapy. Weight gain ranges between 1 to 5 kg, and may be associated with change in body composition with gain in fat mass and loss in lean body mass. Women are unlikely to return to pre-diagnosis weight. Possible mechanisms including inactivity and metabolic changes are explored. Potential interventions are reviewed including exercise, dietary changes and pharmacologic agents. Although breast cancer prognosis does not appear to be significantly impacted, weight gain has negative consequences on quality of life and overall health. Future studies should explore change in body composition, metabolism and insulin resistance. Avoiding weight gain in breast cancer survivors following initial diagnosis and treatment should be encouraged.© 2014 Baishideng Publishing Group Inc. All rights reserved.Key words: Breast cancer; Weight gain; Exercise; Survivorship; Insulin resistance Core tip: Weight gain occurs in the majority of women following breast cancer treatment, especially those who are younger, closer to ideal body weight and who have been treated with chemotherapy. Although weight gain may be modest, changes are consistent with sarcopenic obesity. Women are unlikely to return to pre-diagnosis weight. Although the degree of weight gain does not appear to significantly alter prognosis, associated changes in metabolism and inactivity are of concern. Interventions should be promoted to avoid weight gain. INTRODUCTIONWeight gain following a diagnosis of breast cancer has been reported consistently in women treated for breast cancer, but was an unexpected finding when first described Dixon and colleagues in 1978 [1] . After subsequent reports confirmed this observation, weight gain was included as a known side effect of adjuvant chemotherapy [2] . Despite this, most women appear to be inadequately informed about this possibility, as demonstrated by one study reporting concern about treatment-associated weight gain in only 27% of survivors prior to therapy [3] . WHY IS POST-TREATMENT WEIGHT GAIN OF CONCERN?Obesity is a global issue associated with increased risk of developing post-menopausal breast cancer [4] and a worse prognosis at the time of diagnosis [5] . However, the effect of weight gain following a diagnosis of breast cancer is less well understood. While weight gain following diagnosis does not necessarily lead to obesity or its consequences, any impact on breast cancer prognosis and overall health, patient self-image, or quality of life (QoL) would be an undesirable outcome. These outcomes may be interrelated: weight gain can influence other medical conditions such as diabetes, heart disease, hypertension and hypercholesterolemia that may impact overall survival. For example, Erick...

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“…1 The decreased mortality rate can be attributed to earlier detection and more aggressive treatments. [2][3][4][5] These efforts have resulted in there being more than 2.4 million breast cancer survivors in the United States in 2009. 6 Treatment of breast cancer is multifaceted and varies individually based on the type of tumor and individual risk factors.…”

Section: Introductionmentioning

confidence: 99%

Exercise in Patients With Breast Cancer and Healthy Controls: Energy Substrate Oxidation and Blood Lactate Responses

et al. 2010

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The aim of this study was to compare select aspects of exercise energy metabolism in patients with breast cancer with that of healthy controls across a variety of exercise intensities. Posttreated patients with breast cancer were matched with healthy women based on age, physical fitness level, and menopausal status. Subjects participated in low-, moderate-, and high-intensity submaximal exercise sessions that corresponded with 40% of maximal oxygen consumption (Vo 2max ), 60% Vo 2max , and 70% Vo 2max . Oxygen consumption and respiratory exchange ratio were taken during submaximal exercise sessions to determine substrate oxidation rates for carbohydrate (CHO) and fat. Blood lactate and blood glucose were also measured before and after each of the submaximal exercise sessions as indices of CHO metabolism. Results indicate that the patients with breast cancer had a significantly (P ≤ .05) lower CHO oxidation rate and higher fat oxidation rate at all exercise intensities compared with healthy women. The patients with breast cancer had a significantly (P ≤ .05) lower blood lactate response to exercise across all intensities compared with the healthy women. Glucose responses tended (P < .08) to be more elevated in patients with cancer both before and after the exercise sessions. The findings indicate that posttreated patients with breast cancer have augmented fat metabolism and a reduced CHO-based energy metabolism during submaximal exercise. It is unclear whether these changes are the result of the patient's cancer or their treatment regimen for the cancer.

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A Meta-Analysis of Aerobic Exercise Interventions for Women With Breast Cancer

Cited by 67 publications

References 56 publications

Telephone-delivered nutrition and exercise counselling after auto-SCT: a pilot, randomised controlled trial

Telephone-delivered nutrition and exercise counselling after auto-SCT: a pilot, randomised controlled trial

Weight gain following breast cancer diagnosis: Implication and proposed mechanisms

Exercise in Patients With Breast Cancer and Healthy Controls: Energy Substrate Oxidation and Blood Lactate Responses

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