A Meta-Analysis and Systematic Review on the Association between Human Papillomavirus (Types 16 and 18) Infection and Esophageal Cancer Worldwide

Abstract

BackgroundEsophageal cancer is a common and aggressive malignant tumor. This study aimed to investigate the association between human papillomavirus (HPV) Types 16 and 18 and esophageal carcinoma (EC) in the world population by conducting a meta-analysis.Materials and MethodsComputerized bibliographic and manual searches were performed to identify all eligible literatures between 1982 and 2014. PUBMED (http://www.ncbi.nlm.nih.gov/pubmed/) and CNKI (http://www.cnki.net/) were the primary sources of case-control studies, and key words used include human papillomavirus, HPV, esophageal, esophagus, cancer, carcinoma, and tumor. All searches were performed by reviewing articles and abstracts cited in the published systematic reviews and case-control studies. Prospective studies that reported relative risk (RR) estimates with 95% CIs for the association between HPV and EC were included.ResultsThirty-three randomized studies were identified, and the main features of these trials were included in this systematic review. HPV infection rate in the EC group was 46.5%, while HPV infection rate in the control group was 26.2% (OR = 1.62; 95% CI, 1.33–1.98). In China, the merger OR value was 1.62 (95% CI: 1.26–2.07); while in the Asian region, the merger OR value was 1.63 (95% CI: 1.29–2.04). There were statistical differences in HPV testing due to different detection methods such as PCR, IHC and ISH. In the PCR detection group, the merger OR value was 1.61 (95% CI: 1.33–1.95).ConclusionsThese results indicate that HPV infection and the incidence of EC are closely associated.

Epidemiology, etiology, and prevention of esophageal squamous cell carcinoma in China

“…A recent systematic review of the relationship between HPV infection (types 16 and 18) and esophageal cancer worldwide found that HPV is closely associated with esophageal cancer in China, and in other countries, with an integrated OR=1.62 (95% CI: 1.33–1.98) 42 . The highest HPV prevalence was found in Africa and Asia; notably, this result was obtained among Chinese studies from provinces with high ESCC incidence rates 43 .…”

Frequency of HPV detection in chagasic megaesophagus associated or not with esophageal squamous cell carcinoma

“…Some of the HPV types detected in our analysis coincide with that reported in our previous study, also using the Luminex technique 34 . These types identi ed with low frequency are little studied in the literature 49 .…”

Chondroradionecrosis of the larynx in 63 years after radiation therapy: a case report

“…В научной литературе хорошо известны случаи возникновения рака щитовидной железы спустя годы после лучевого воздействия [9]. Предположительно, персистенция вируса папилломы человека вызвала процесс малигнизации в пищеводе, что является одним из доказанных факторов риска [10].…”