A meningitis case due to Stenotrophomonas maltophilia and review of the literature

Yemisen, Mucahit; Mete, Bilgül; Tunalı, Yusuf; Yentür, Ercüment; Öztürk, Recep

doi:10.1016/j.ijid.2008.03.028

Cited by 25 publications

(33 citation statements)

References 17 publications

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“…Inducible beta-lactamase activity (including L1 metallo-β-lactamase and L2 serine-β-lactamase), efflux mechanism, aminoglycoside modifying enzyme activity, biofilm formation, and production of extracellular slime or glycocalyx are responsible for its resistance [12].…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics and risk factors of infections caused by Stenotrophomonas maltophilia in a hospital in northwest China

Meng

Zhang

et al. 2014

J Infect Dev Ctries

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Introduction: Stenotrophomonas maltophilia infections have recently increased in importance in China, particularly in intensive care units (ICUs). The aim of this study was to investigate the clinical characteristics and risk factors of S. maltophilia infection in ICU of a hospital in northwest China. Methodology: The characteristics and outcomes of patients with any type of S. maltophilia infection at Shaanxi Provincial People's Hospital, Shaanxi, China, over a two-year period (from July 2011 to June 2013) were studied. S. maltophilia antimicrobial susceptibility was tested with the agar dilution method. The risk factors for all-cause in-hospital mortality were assessed with multivariate logistic regression. Results: Forty patients (median age, 72 years; 77.5% males) with S. maltophilia infection were identified. The main type of infection was lower respiratory tract infection (97.5%); one patient had a bloodstream infection. A total of 97.5% patients were infected with two or more organisms at the same time. The main characteristics of the patients were prolonged use of mechanical ventilation, urethral catheter, and central venous catheter before the infections occurred. The case number of infection was not different in the four seasons. High in vitro sensitivity was observed to minocycline (91.2%), levofloxacin (85.3%), and trimethoprim-sulfamethoxazole (79.4%). Most patients received therapy with a combination of agents. The crude mortality was 50%. By multivariate analysis, low albumin content and hypotension were the independent prognostic factors for mortality. Conclusions: Appropriate antimicrobial treatment had no positive impact on mortality. The impacts of albumin supplements and increasing blood pressure on mortality require further clinical studies.

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Section: Introductionmentioning

confidence: 99%

Clinical characteristics and risk factors of infections caused by Stenotrophomonas maltophilia in a hospital in northwest China

Meng

Zhang

et al. 2014

J Infect Dev Ctries

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“…Meningitis which is caused by S. maltophilia is exceedingly rare and to the best of our knowledge, only 18 cases have been reported till date [2][3][4][5]. An analysis of the cases which were reported in literature, which was done, revealed that risk factors which were associated with S. maltophilia infection were prematurity, neurosurgical procedures (especially shunts and drainages), intra-cranial haemorrhages and malignancies.…”

Section: Discussionmentioning

confidence: 99%

Meningitis due to Stenotrophomonas maltophilia after a Neurosurgical Procedure

Sood

Vaıd²,

Bhartiya³

2013

JCDR

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“…This bacterium is found in several environments such as water, soil, plants, food and hospital settings (Nicodemo & Garcia -Paez 2007;Yemisen et al, 2008). It is increasingly recognised as a significant cause of hospital acquired infection particularly among severely debilitated and immunosuppressed patients, those receiving longterm antimicrobial therapy and those with indwelling central venous catheters.…”

Section: Stenotrophomonas Maltophilia (S Maltophilia)mentioning

confidence: 99%