A Mendelian Randomization Study on Association of Alpha-synuclein and GPNMB with Parkinson’s Disease Risk and Progression
Jifeng Guo,
Lizhi Li,
Zhenhua Liu
et al.
Abstract:The prevalence of Parkinson’s disease (PD) is increasing because of the aging population. Early diagnosis and prognosis of PD remain challenging, suggesting that seeking appropriate biomarkers for PD is crucial. GPNMB and Alpha-synuclein (α-syn) have been reported to contribute to PD pathogenesis and are correlated with PD onset and disease progression. We utilized Mendelian Randomization (MR) analysis to elucidate the association of GPNMB and α-syn with PD and its disease progression. Five MR methods were emp… Show more
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