A mendelian randomization study on causal effects of 25(OH)vitamin D levels on attention deficit/hyperactivity disorder

Libuda, Lars; Naaresh, Roaa; Ludwig, Christine; Laabs, Björn‐Hergen; Antel, Jochen; Föcker, Manuel; Peters, Triinu

doi:10.1007/s00394-020-02439-2

Cited by 12 publications

(8 citation statements)

References 44 publications

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“…OCD and ADHD, the most common comorbidities in CTD, have also been linked to lower levels of vitamin D [ 6 , 21 ]. However, the result has been inconsistent [ 26 , 43 ] and the salience of these observations remains to be understood.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D levels in children and adolescents with chronic tic disorders: a multicentre study

Bond

Moll

Roselló

et al. 2021

Eur Child Adolesc Psychiatry

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This study investigated whether vitamin D is associated with the presence or severity of chronic tic disorders and their psychiatric comorbidities. This cross-sectional study compared serum 25-hydroxyvitamin D [25(OH)D] (ng/ml) levels among three groups: children and adolescents (3–16 years) with CTD (n = 327); first-degree relatives (3–10 years) of individuals with CTD who were assessed for a period of up to 7 years for possible onset of tics and developed tics within this period (n = 31); and first-degree relatives who did not develop tics and were ≥ 10 years old at their last assessment (n = 93). The relationship between 25(OH)D and the presence and severity of tics, as well as comorbid obsessive–compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD), were analysed controlling for age, sex, season, centre, latitude, family relatedness, and comorbidities. When comparing the CTD cohort to the unaffected cohort, the observed result was contrary to the one expected: a 10 ng/ml increase in 25(OH)D was associated with higher odds of having CTD (OR 2.08, 95% CI 1.27–3.42, p < 0.01). There was no association between 25(OH)D and tic severity. However, a 10 ng/ml increase in 25(OH)D was associated with lower odds of having comorbid ADHD within the CTD cohort (OR 0.55, 95% CI 0.36–0.84, p = 0.01) and was inversely associated with ADHD symptom severity (β = − 2.52, 95% CI − 4.16–0.88, p < 0.01). In conclusion, lower vitamin D levels were not associated with a higher presence or severity of tics but were associated with the presence and severity of comorbid ADHD in children and adolescents with CTD.

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Section: Introductionmentioning

confidence: 99%

Vitamin D levels in children and adolescents with chronic tic disorders: a multicentre study

Bond

Moll

Roselló

et al. 2021

Eur Child Adolesc Psychiatry

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“…The participants, the physician who prescribed the medications, and the nutritionist were blinded to the allocated treatment. According to previous studies, 2000 IU of vitamin D is an optimum dosage for preventing diseases in children and adults without any side effects [ 43 , 44 ]. The intervention group received two tablets of vitamin D3 (1000 IU vitamin D3 per each tablet) daily for 3 months.…”

Section: Methodsmentioning

confidence: 99%

Effect of Vitamin D on Paraxonase-1, Total Antioxidant Capacity, and 8-Isoprostan in Children with Attention Deficit Hyperactivity Disorder

Honarvar

Samadi

Chimeh

et al. 2022

International Journal of Clinical Practice

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Background and Objective. Attention deficit hyperactivity disorder (ADHD) is one of the most common neurobehavioral disorders in children. Increased oxidative stress and decreased vitamin D may be associated with neurodevelopmental and psychiatric disorders, such as ADHD. The purpose of this study was to investigate the effect of vitamin D supplementation on oxidative stress in children with attention deficit hyperactivity disorder. Method. In this double-blind, randomized, placebo-controlled trial, 75 children (aged 6–12) diagnosed with ADHD were randomly assigned into two groups. The supplementation group received vitamin D3 (2000 IU), and the control group received a placebo for 3 months. Blood samples were collected at baseline and after intervention to analyze the 25(OH)D, paraxonase-1 activity (PON-1), Total Antioxidant Capacity (TAC), and 8-isoprostan levels. Results. A significant rise in circulating 25(OH)D was observed in the vitamin D group versus the placebo group at the end of the study. There was no reduction in 8-isoprostan levels in the vitamin D group compared to the placebo group. Serum paraxonase-1 and TAC concentration decreased in both groups, but these alterations were not statistically significant in the treatment group versus the placebo group at the end of the intervention. Conclusion. Vitamin D supplementation for 3 months did not have beneficial effects on biomarkers of oxidative stress status. To confirm these findings, further studies on children are suggested.

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“…Previous studies have reported that the severity of TD is highest between 10 and 12 years of age and that symptoms of TD can be improved by vitamin D supplementation ( 1 , 11 ). Contrastingly, some studies report no relation between vitamin D deficiency and severity of TD ( 12 , 13 ). To verify the correlation between vitamin D levels and TD severity, we evaluated this association in children with TD and in healthy controls in Shanghai, China.…”

Section: Introductionmentioning

confidence: 91%

Correlation Between Tic Disorders and Serum 25-Hydroxyvitamin D Levels in Chinese Children

Wang

et al. 2022

Front. Pediatr.

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ObjectiveTo explore the correlation between serum 25-hydroxyvitamin D levels and tic disorders (TDs) in Chinese children.MethodsWe selected 2960 children with TD and 2665 healthy controls, aged 5–14 years, from the Department of Neurology of the Shanghai Children’s Hospital. Serum 25-hydroxyvitamin D levels and degrees of vitamin D deficiency were compared between patients with TD and healthy children.ResultsThe mean serum 25-hydroxyvitamin D level in the TD group was significantly lower than that in the control group (P < 0.001). The proportion of patients with 25-hydroxyvitamin D deficiency in the TD group was significantly higher than that in the control group. However, there was no correlation between 25-hydroxyvitamin D deficiency and the severity of TD. In addition, for age-wise comparison, mean levels of 25-hydroxyvitamin D and its deficiency in the TD group were the most significant in children over 9 years of age.ConclusionThere is a correlation between 25-hydroxyvitamin D deficiency and TD in Chinese children, but not between 25-hydroxyvitamin D deficiency and the severity of TD. There was a correlation between age and deficiency of 25-hydroxyvitamin D; this deficiency was most pronounced among those over the age of 9 years.

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A mendelian randomization study on causal effects of 25(OH)vitamin D levels on attention deficit/hyperactivity disorder

Cited by 12 publications

References 44 publications

Vitamin D levels in children and adolescents with chronic tic disorders: a multicentre study

Vitamin D levels in children and adolescents with chronic tic disorders: a multicentre study

Effect of Vitamin D on Paraxonase-1, Total Antioxidant Capacity, and 8-Isoprostan in Children with Attention Deficit Hyperactivity Disorder

Correlation Between Tic Disorders and Serum 25-Hydroxyvitamin D Levels in Chinese Children

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