2022
DOI: 10.3389/fendo.2022.802453
|View full text |Cite
|
Sign up to set email alerts
|

A MEN1 Patient Presenting With Multiple Parathyroid Adenomas and Transient Hypercortisolism: A Case Report and Literature Review

Abstract: BackgroundMultiple endocrine neoplasia type 1 (MEN1) is a hereditary endocrine syndrome caused by mutations in MEN1 tumor suppressor gene.Case PresentationA 53-year-old Chinese female was admitted to Division of Endocrinology, Tongji Hospital, for hypercalcemic crisis. Increased level of parathyroid hormone (PTH) was confirmed by laboratory tests, and imaging examination showed multiple parathyroid adenomas. Based on gene analysis, the patient was diagnosed as MEN1 associated hyperparathyroidism (HPT) by gene … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

0
4
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(4 citation statements)
references
References 44 publications
0
4
0
Order By: Relevance
“…At present, there is no relevant research to confirm how MEN1 is involved in the regulation of urinary cortisol levels. However, case reports (Chen et al., 2022 ) and other studies (Vaduva et al., 2020 ) have suggested that MEN1 had a certain correlation with cortisol levels. Further research may bring varying discoveries.…”
Section: Discussionmentioning
confidence: 92%
“…At present, there is no relevant research to confirm how MEN1 is involved in the regulation of urinary cortisol levels. However, case reports (Chen et al., 2022 ) and other studies (Vaduva et al., 2020 ) have suggested that MEN1 had a certain correlation with cortisol levels. Further research may bring varying discoveries.…”
Section: Discussionmentioning
confidence: 92%
“…21 Adrenal lesions are also common in MEN1 patients, with a prevalence ranging between 3.4% and 61.1%. 22 Hypersecretion of hormones is unusual, and most tumours are nonfunctional. 23 In our study, the identification of two ↑, increase; ↓, decrease; b, body; h, head; l, left; n, neck; NET, neuroendocrine tumour; r, right; SPECT/CT, 99m Tc-Sestamibi SPECT/CT; t, tail; u, uncinate.…”
Section: Discussionmentioning
confidence: 99%
“…Adrenal lesions are also common in MEN1 patients, with a prevalence ranging between 3.4% and 61.1% 22 . Hypersecretion of hormones is unusual, and most tumours are nonfunctional 23 .…”
Section: Discussionmentioning
confidence: 99%
“…Additional studies further solidified the role of MEN1 in the development of both esophageal and uterine leiomyomata ( 94 ), although LOH was not detected in four of seven leiomyomas from a single patient who had lung, esophageal and uterine tumors. Other cases of uni- and multifocal smooth muscle tumors in MEN1 patients have been reported in the English literature ( 24 , 25 , 52 , 87 , 95 104 ) and, in addition to the aforementioned sites, these tumors have arisen in the ureter ( 96 ), bladder ( 97 ), epididymis ( 87 ), ventricle ( 87 ), and small bowel ( 87 , 103 ). Most cases have been in females and these neoplasms occur more rarely in men ( 87 89 , 91 , 96 ) ( Figure 4 ).…”
Section: Smooth Muscle Tumorsmentioning
confidence: 99%