A Membrane-Targeted Peptide Inhibiting PtxA of Phosphotransferase System Blocks &lt;b&gt;&lt;i&gt;Streptococcus mutans&lt;/i&gt;&lt;/b&gt;

Xiang, Shao-Wen; Shao, Jianguo; Wu, Xinyu; Xu, Xiuli; Zhao, Wei

doi:10.1159/000489607

Cited by 14 publications

(7 citation statements)

References 52 publications

(57 reference statements)

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“…When exposed to a high-sugar diet, diners in the streptococci group metabolize carbohydrates and produce acids that will demineralize the tooth structure. Among the agents that will participate in this process, Streptococcus mutans ( S. mutans ) is the primary pathogen, whose mechanism of virulence has been the most studied and known when compared to the other species (Pitts et al, 2017, Xiang et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Dose-response evaluation of a copaiba-containing varnish against streptococcus mutans in vivo

Valadas

Gurgel

Mororó

et al. 2019

Saudi Pharmaceutical Journal

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Section: Introductionmentioning

confidence: 99%

Dose-response evaluation of a copaiba-containing varnish against streptococcus mutans in vivo

Valadas

Gurgel

Mororó

et al. 2019

Saudi Pharmaceutical Journal

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“…D-Nal-Pac-525 exhibited improved antimicrobial activity compared to Pac-525 by showing activity against S. mutans [ 81 ]. C10-KKWW was identified as being active against S. mutans from a lipopeptide library [ 82 ]. The difference here was that it was identified by virtual screening.…”

Section: Discussionmentioning

confidence: 99%

Peptide Designs for Use in Caries Management: A Systematic Review

Zhang

Niu

et al. 2023

IJMS

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The objective of this study was to review the design methods that have been used to create peptides for use in caries management. Two independent researchers systematically reviewed many in vitro studies in which peptides were designed for use in caries management. They assessed the risk of bias in the included studies. This review identified 3592 publications, of which 62 were selected. Forty-seven studies reported 57 antimicrobial peptides. Among them, 31 studies (66%, 31/47) used the template-based design method; 9 studies (19%, 9/47) used the conjugation method; and 7 studies (15%, 7/47) used other methods, such as the synthetic combinatorial technology method, the de novo design method and cyclisation. Ten studies reported mineralising peptides. Seven of these (70%, 7/10) used the template-based design method, two (20%, 2/10) used the de novo design method, and one study (10%, 1/10) used the conjugation method. In addition, five studies developed their own peptides with antimicrobial and mineralising properties. These studies used the conjugation method. Our assessment for the risk of bias in the 62 reviewed studies showed that 44 publications (71%, 44/62) had a medium risk and that 3 publications had a low risk (5%, 3/62). The two most common methods for developing peptides for use in caries management that were used in these studies were the template-based design method and the conjugation method.

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“…Besides, as a synthetic peptide, histatin-5 could interfere with the interaction with cell membranes of bacteria by inhibiting PtxA blocking system of Phosphotransferase Streptococcus mutans. As a result, the peptide translocation like Lascorbate, which aimed to interfere with the biofilm formation of S. mutans can be bothered [32]. As cellular response strategy, histatin act to stabilize the bacterial cell membranes assimilated with the surface of bacterial cells, thus promoting cell damage through interaction with the bacterial cell membrane to generate a hydrophilic channel [33].…”

Section: Discussionmentioning

confidence: 99%

Spectrophotometric Analysis of Streptococcus mutans Growth and Biofilm Formation in Saliva and Histatin-5 Relate to pH and Viscosity

Syafriza

Sutadi

Primasari

et al. 2021

Pesqui. Bras. Odontopediatria Clín. Integr.

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Objective: To analyze the ability of saliva in controlling the growth and the biofilm formation of Streptococcus mutans (S. mutans) as well as the effect of histatin-5 anti-biofilm relate to pH and saliva viscosity. Material and Methods: The S. mutans biofilm assayed by crystal violet 1% and its growth measured by spectrophotometer. The saliva viscosity was analyzed by viscometer, and pH of saliva was measured by pH meter. Results: Based on the optical density values, growth of S. mutans in saliva ranged <300 CFU/mL (0.1 nm) at concentrations of 25%, 12.5% and 6.25% for 24 hours. Whereas at the 48 h and 72 h period of incubation shown an increase in growth of S. mutans ranged 300-600 CFU/mL (0.2-0.36 nm). The inhibitory biofilm formation of S. mutans in saliva was significantly higher at concentrations of 12.5% and 6.25% at 24 h incubation times on a moderate scale, whereas the histatin-5 was effective to inhibit S. mutans biofilm on the 50 and 25 ppm. The saliva possessed a higher inhibitory of biofilm S. mutans than histatin-5 and good level viscosity (0.91-0.92 cP). Conclusion: The saliva was able to control the growth of S. mutans, and histatin-5 can inhibit the biofilm formation S. mutans. Furthermore, the saliva was also able to respond to the pH change with good viscosity of saliva.

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A Membrane-Targeted Peptide Inhibiting PtxA of Phosphotransferase System Blocks <b><i>Streptococcus mutans</i></b>

Cited by 14 publications

References 52 publications

Dose-response evaluation of a copaiba-containing varnish against streptococcus mutans in vivo

Dose-response evaluation of a copaiba-containing varnish against streptococcus mutans in vivo

Peptide Designs for Use in Caries Management: A Systematic Review

Spectrophotometric Analysis of Streptococcus mutans Growth and Biofilm Formation in Saliva and Histatin-5 Relate to pH and Viscosity

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