A Membrane Lipid Signature Unravels the Dynamic Landscape of Group 1 ILCs
Halle C. Frey,
Xin Sun,
Fatima Oudeif
et al.
Abstract:In an era where the established lines between cell identities are blurred by intra-lineage plasticity, distinguishing between stable and transitional states becomes imperative. This challenge is particularly pronounced within the Group 1 ILC lineage, where the similarity and plasticity between NK cells and ILC1s obscure their classification and the assignment of their unique contributions to immune regulation. This study exploits the unique property of Asialo-GM1 (AsGM1), a membrane lipid associated with cytot… Show more
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