A Mediterranean dietary style influences TNF–alpha and VCAM–1 coronary blood levels in unstable angina patients

Serrano-Martínez, Manuel; Palacios, M. Hevia; Martínez-Losa, E; Lezáun, R.; Maraví, César; Prado, Marco A. M.; Martínéz, J. Alfredo; Martínez‐González, Miquel A.

doi:10.1007/s00394-004-0532-9

Cited by 67 publications

(42 citation statements)

References 43 publications

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“…This misclassification bias is even more likely when concentrations of inflammatory markers are measured in peripheral blood, as in the present study, rather than in specific tissues sites where they are produced in evaluating inflammation status. Indeed, a clear association was found in an observational study in which the inflammatory markers were measured in coronary sinus blood (Serrano-Martínez et al, 2005). Also, there is a reasonable possibility that the score we have used might not be discriminatory enough of the adherence to the Mediterranean dietary pattern.…”

Section: Discussionmentioning

confidence: 95%

Components of the mediterranean-type food pattern and serum inflammatory markers among patients at high risk for cardiovascular disease

et al. 2007

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Objective: To evaluate associations between components of the Mediterranean diet and circulating markers of inflammation in a large cohort of asymptomatic subjects at high risk for cardiovascular disease. Subjects/Methods: A total of 339 men and 433 women aged between 55 and 80 years at high cardiovascular risk because of presence of diabetes or at least three classical cardiovascular risk factors, food consumption was determined by a semiquantitative food frequency questionnaire. Serum concentrations of high-sensitivity C-reactive protein (CRP) were measured by immunonephelometry and those of interleukin-6 (IL-6), intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) by enzyme-linked immunosorbent assay. Results: After adjusting for age, gender, body mass index, diabetes, smoking, use of statins, non-steroidal antiinflammatory drugs and aspirin, a higher consumption of fruits and cereals was associated with lower concentrations of IL-6 (P for trend 0.005;both). Subjects with the highest consumption of nuts and virgin olive oil showed the lowest concentrations of VCAM-1, ICAM-1, IL-6 and CRP; albeit only for ICAM-1 was this difference statistically significant in the case of nuts (for trend 0.003) and for VCAM-1 in the case of virgin olive oil (P for trend 0.02). Participants with higher adherence to the Mediterranean-type diet did not show significantly lower concentrations of inflammatory markers (Po0.1 for VCAM-1 and ICAM-1).

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Section: Discussionmentioning

confidence: 95%

Components of the mediterranean-type food pattern and serum inflammatory markers among patients at high risk for cardiovascular disease

et al. 2007

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“…The major fat present in olive oil is the monounsaturated 18-carbon oleic acid. A wide array of studies have shown that olive oil exerts important anti-inflammatory effects (Visioli and Galli 2002;Esposito et al, 2004;Beauchamp et al, 2005;Serrano-Martínez et al, 2005) and antioxidant effects (Ramírez-Tortosa et al, 1999;Visioli and Galli, 2002;Pitsavos et al, 2005), which may explain why it has been reported to be negatively associated with the risk of CHD in epidemiologic studies (FernandezJarne et al, 2002;Barzi et al, 2003). These anti-inflammatory and antioxidant effects have been partly explained because of the high content of polyphenols present in virgin olive oil (Carrasco-Pancorbo et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Dietary fat intake and the risk of osteoporotic fractures in the elderly

et al. 2007

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Objective: To explore the association between fat intake, serum lipids and the risk of osteoporotic fractures in the elderly. Design: A hospital-based case-control study. Setting: The study was conducted at a tertiary centre and referral hospital for the province of Jaén (Spain). Subjects: Cases (n ¼ 167) were patients aged 65 years or more with a low-energy fracture selected from the population attended at the hospital. Controls (patients without antecedents of any fracture) were 1:1 matched to cases by sex and age (n ¼ 167). Methods: Diet was assessed by a semiquantitative food frequency questionnaire. Serum total cholesterol and high-density lipoprotein (HDL) cholesterol were also measured. Results: Participants in the two upper quartiles of polyunsaturated fat (PUFA) intake showed an increased risk of fracture, with statistically significant differences with respect to the first quartile in the adjusted model (odds ratio (OR) ¼ 3.59; 95% confidence interval (CI) ¼ 1.06-12.1 and OR ¼ 5.88; 95% CI ¼ 1.38-25.02); P ¼ 0.01 for the trend test). A higher ratio of monounsaturated fat (MUFA) to PUFA was associated with a reduced risk of fracture (OR ¼ 0.20; 95% CI ¼ 0.07-0.60 for the fourth quartile; P ¼ 0.002 for the trend test). The intake of omega-6 fatty acids was associated with an elevated risk of fracture (OR ¼ 3.41; 95% CI ¼ 1.05-11.15 for the fourth quartile; P ¼ 0.01 for the trend test). HDL-cholesterol levels were inversely associated with the risk of fracture (test for trend P ¼ 0.03 across quartiles). Conclusions: PUFA intake was associated with an increased risk of osteoporotic fractures in the elderly, whereas a high ratio of MUFA:PUFA was associated with decreased risk.

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“…Therefore, it can be suggested that the fibre content in association with some other antioxidant components may influence the transient oxidative stress that occurs after macronutrient ingestion. The Mediterranean diet has also been related to inflammatory markers in coronary blood vessels, and may be protective against the production of inflammatory mediators in artery walls [142].…”

Section: The Mediterranean Dietmentioning

confidence: 99%

The Mediterranean food pattern: a good recipe for patients with the metabolic syndrome

Amezaga

Zulet

Marti

et al. 2008

Mediterr J Nutr Metab

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The metabolic syndrome is a complex condition characterized by dyslipidaemia, high blood pressure, impaired glucose tolerance and abdominal fat accumulation. Subjects with the metabolic syndrome are at high risk of atherosclerosis and coronary heart disease. A comprehensive approach is required for patients suffering this cluster of clinical manifestations. Indeed, subjects with the metabolic syndrome could benefit from life-style modifications, particularly through exercise and diet. In this article, the evidence regarding the role of diet, in particular the role of food patterns based on the Mediterranean-style diet, in preventing and treating the metabolic syndrome are reviewed. Keywords Mediterranean diet · Metabolic syndrome · Diet IntroductionThere are many definitions of the metabolic syndrome, being still a matter of debate ( Table 1). The metabolic syndrome has its origins in 1923 when Kylin described a syndrome involving hypertension, hyperglycaemia and hyperuricaemia [1]. Later, Vague in 1947 linked abdominal obesity to metabolic abnormalities (i.e. diabetes, atherosclerosis, gout and calculi) [2]. In 1967, Avogaro et al. described six obese patients with diabetes, hypercholesterolaemia, and marked hypertriglyceridaemia, all of whom improved on a hypocaloric and low-carbohydrate diet [3]. In the 1970s, Phillips suggested associations of aging, obesity and sex hormone-associated clinical manifestations with heart disease [4,5]. In the late 1980s, Reaven proposed insulin resistance as the critical factor and coined the name syndrome-X [6].However, the most extensive definitions were established by the World Health Organization (WHO) and the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATPIII). In these definitions an enhanced cholesterol/high-density lipoprotein (HDL) ratio is considered a factor in the metabolic syndrome as well as elevated low-density lipoprotein cholesterol, atherogenic dyslipidaemia, insulin resistance, hypertension, abdominal obesity and elevated levels of several inflammatory markers [7,8]. In 2005 the International Diabetes Federation (IDF) emphasized abdominal obesity as the initiating factor in metabolic syndrome [9]. Although the definition of the metabolic syndrome makes little difference to prognosis [10,11], the IDF definition appears to be the most useful in clinical practice and considers different ethnic-related definitions of obesity.Each of the abnormalities promotes atherosclerosis independently, but the clustering of risk factors signifi- cantly reduces the quality of life [12] and increases the risk of cardiovascular morbidity and mortality. Indeed, the metabolic syndrome has been associated with an approximate twofold increased risk of cardiovascular morbidity and mortality in a European population [13]. The risk of cardiovascular morbidity and mortality is significantly higher among people with metabolic syndrome [14] even in the absence of baseline health conditions such as cardiovascular disease (CVD) and diabetes [15].The INTER...

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A Mediterranean dietary style influences TNF–alpha and VCAM–1 coronary blood levels in unstable angina patients

Abstract: Adherence to a Mediterranean dietary pattern may protect against coronary artery wall production of inflammatory mediators. This finding could provide a novel mechanistic explanation for the recognized lower coronary risk associated with a Mediterranean diet.

Cited by 67 publications

References 43 publications

Components of the mediterranean-type food pattern and serum inflammatory markers among patients at high risk for cardiovascular disease

Components of the mediterranean-type food pattern and serum inflammatory markers among patients at high risk for cardiovascular disease

Dietary fat intake and the risk of osteoporotic fractures in the elderly

The Mediterranean food pattern: a good recipe for patients with the metabolic syndrome

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