A medical device containing purified bovine colostrum (Monurelle Biogel) in the treatment of vulvovaginal atrophy in postmenopausal women: Retrospective analysis of urinary symptoms, sexual function, and quality of life

Abstract

Monurelle Biogel is an effective treatment for VVA in postmenopausal women, improving sexual life, urinary symptoms, and QoL.

Bovine Colostrum Applications in Sick and Healthy People: A Systematic Review

“…Figure 1 represents the Flow Chart of the study selection process. Twenty-four out the 28 studies included the full texts [ 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ], while 4 were available as abstracts only [ 56 , 57 , 58 , 59 ]. The majority of these articles involved participants from Europe ( n = 14; 52%), 6 (22%) from Asia, 3 (11%) from Africa 1 (4%) from America and 3 (11%) from Oceania.…”

“…Therefore, the papers were classified by publication type (full texts or abstracts), BC administration route (systemic oral or topical) and study population. BC topical application in uro-gynecology [ 33 , 34 , 35 ] ( Table 2 ), BC as dietary supplement in the sporting population [ 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ] ( Table 3 ), BC as dietary supplement in the pediatrics and preterm infants [ 47 , 48 , 49 , 50 , 51 , 52 , 53 ] ( Table 4 ), BC as dietary supplement in the elderly [ 54 ] ( Table 5 ), BC administration in critically ill patients [ 55 ] ( Table 6 ), abstracts [ 56 , 57 , 58 , 59 ] ( Table 7 ) and then a systematic review on BC clinical applications [ 21 ] ( Table 8 ). In Table 9 the risk of bias of the included (full texts) RCTs was reported according to the CCRBT method.…”

“…Three studies (1 RCT, 2 OS) were on topical applications of BC-based creams on various vaginal conditions and recruiting only female participants with a mean age ranged from 27 to 61 years [ 33 , 34 , 35 ]. Twenty-four papers (23 RCTs, 1 OS) assessed the efficacy of BC as dietary supplement in various populations [ 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 ], including diseased ones [ 47 , 48 , 49 , 50 , 51 , 52 , 53 , 55 , 56 , 57 , 58 , 59 ] and healthy people [ 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ...…”

“…Limited information on BC and placebo products were available by the 4 RCTs (all involving pediatric subjects) available as abstracts [ 56 , 57 , 58 , 59 ]. Surrogate outcomes were used in 15 studies [ 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 50 , 51 , 54 , 55 ] while 8 [ 33 , 34 , 35 , 36 , 48 , 49 , 52 , 53 ] assessed morbidity outcomes. The 4 abstracts measured primary outcomes.…”

Awareness about Vulvovaginal Aesthetics Procedures among Medical Students and Health Professionals in Saudi Arabia

“…23 The decision about VVAPs in menopausal women needs special considerations, and one must give priority to conservative management rather than to surgery. 24,25 There should be evidence-based guidelines and algorithms to be followed by practitioners to help in decisions regarding VVAPs. 14,26,27 The authors have suggested the step-by-step approach for the enhancement of awareness about VVAPs in medical education.…”