A mechanochemical model of striae distensae

Gilmore, Stephen; Vaughan, Benjamin L.; Madzvamuse, Anotida; Maini, Philip K.

doi:10.1016/j.mbs.2012.06.007

Cited by 45 publications

(84 citation statements)

References 26 publications

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“…Although, based on previous publications and on our gene expression results, we assume that the increased MMP-3 and MMP-9 activity in dissection patients is responsible for accelerated degradation of the connective tissue fibres [4,5,24]. Besides the aortic wall, this destruction process may affect the dermis and the subcutaneous layer of the skin as well.…”

Section: Discussionmentioning

confidence: 57%

Possible extracardiac predictors of aortic dissection in Marfan syndrome

Ágg

Benke

Szilveszter

et al. 2014

BMC Cardiovasc Disord

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BackgroundAccording to previous studies, aortic diameter alone seems to be insufficient to predict the event of aortic dissection in Marfan syndrome (MFS). Determining the optimal schedule for preventive aortic root replacement (ARR) aortic growth rate is of importance, as well as family history, however, none of them appear to be decisive. Thus, the aim of this study was to search for potential predictors of aortic dissection in MFS.MethodsA Marfan Biobank consisting of 79 MFS patients was established. Thirty-nine MFS patients who underwent ARR were assigned into three groups based on the indication for surgery (dissection, annuloaortic ectasia and prophylactic surgery). The prophylactic surgery group was excluded from the study. Transforming growth factor-β (TGF-β) serum levels were measured by ELISA, relative expression of c-Fos, matrix metalloproteinase 3 and 9 (MMP-3 and −9) were assessed by RT-PCR. Clinical parameters, including anthropometric variables - based on the original Ghent criteria were also analyzed.ResultsAmong patients with aortic dissection, TGF-β serum level was elevated (43.78 ± 6.51 vs. 31.64 ± 4.99 ng/l, p < 0.0001), MMP-3 was up-regulated (Ln2α = 1.87, p = 0.062) and striae atrophicae were more common (92% vs. 41% p = 0.027) compared to the annuloaortic ectasia group.ConclusionsWe found three easily measurable parameters (striae atrophicae, TGF-β serum level, MMP-3) that may help to predict the risk of aortic dissection in MFS. Based on these findings a new classification of MFS, that is benign or malignant is also proposed, which could be taken into consideration in determining the timing of prophylactic ARR.

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Section: Discussionmentioning

confidence: 57%

Possible extracardiac predictors of aortic dissection in Marfan syndrome

Ágg

Benke

Szilveszter

et al. 2014

BMC Cardiovasc Disord

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“…Numerous risk factors, such as topical or systemic use of corticosteroids, pregnancy, adolescence, weight variation and tissue expansion, Cushing, and Marfan syndrome, have been associated with the presence of striae 3,8–10. The genetic predisposition, family history, race and skin type also represent etiological risk factors 6.…”

Section: Introductionmentioning

confidence: 99%

“…Among all forms of SD, striae gravidarum appear with a high prevalence, estimated at up to 90% of pregnant women. The most important factors involved in pathogenesis of striae gravidarum are the mechanical stress of the skin, hormonal variations and pre-existing dermal pathology 3,8,11,12…”

Section: Introductionmentioning

confidence: 99%

“…Excessive mechanical stretching of the skin determines the rupture of the elastic fibers while the fibroblasts are unable to repair the components of the extracellular matrix 14. The quality of fibroblasts is also altered in striae, with a reduction in fibronectin, and type I and type III procollagen expression in fibroblasts from SD 8. The atrophic aspect of SD is determined by the decrease of the amounts of fibrillin surrounding the dermoepidermal junction and the elastin in the papillary dermis, together with the realignment of elastin and fibrillin fibers in deep dermis 1,11…”

Section: Introductionmentioning

confidence: 99%

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Improvement of skin condition in striae distensae: development, characterization and clinical efficacy of a cosmetic product containing <em>Punica granatum</em> seed oil and <em>Croton lechleri</em> resin extract

Bogdan¹,

Iurian

Tomuță

et al. 2017

DDDT

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Striae distensae are a frequent skin condition associated with pregnancy, weight change or lack of skin elasticity. The aim of this research was to obtain a topical product containing herbal active ingredients with documented antioxidant and anti-inflammatory activity (Punica granatum seed oil and Croton lechleri resin extract) and demonstrate its positive effect on prevention and treatment of striae distensae. First, the cream base formulation was optimized through experimental design. Secondly, the cream containing the two active ingredients was investigated in an interventional nonrandomized clinical trial. The clinical outcome was assessed through biophysical parameters and ultrasonographic evaluation. The state of the skin was evaluated by biophysical measurements and ultrasonography at the beginning of the study and after 3 and 6 weeks. The experimental design was successfully used to set the best ranges for the technological and formulation factors to obtain a cosmetic formulation with optimal characteristics. The study of clinical efficacy on the optimal formulation revealed an increase in the dermis thickness, hydration and elasticity values in both groups after 6 weeks of cream application. The new oil-in-water cream containing P. granatum seed oil and C. lechleri resin extract can be helpful in the prevention or improving of skin changes associated with striae.

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“…The exact etiology of striae is controversial, partly because of the variability in the clinical situations in which they arise. Different hypotheses on their development are found in the literature, in which the etiologic mechanisms are usually classified under the headings of genetic predisposition, as well as biochemical, hormonal, and mechanical disorders [4,5].…”

Section: Introductionmentioning

confidence: 99%

Histological and quantitative morphometric evaluation of striae distensae treated by long-pulsed 1064-nm Nd

El-Ramly¹,

El-Hanafy²,

Maadawi³

et al. 2015

Journal of the Egyptian Womenʼs Dermatologic Society

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BackgroundStriae distensae are frequent undesirable skin lesions that result in considerable esthetic concern. Treatment has always been challenging. Several modalities are available; however, none of them is consistently effective. Laser has become a popular therapeutic alternative. ObjectiveThe aim of this study was to evaluate the possible therapeutic effect of a long-pulsed 1064 nm Nd:YAG laser in striae distensae using histological and quantitative morphometric studies. Patients and methods Forty female patients with striae (group I: striae rubra and group II: striae alba) were included. All patients received four laser sessions at 4-week intervals. Three skin biopsies were obtained from every patient: one from normal control skin, the second from the selected striae before treatment, and the third from the same striae 1 month after treatment. Paraffin-embedded skin sections were subjected to histological and quantitative morphometric studies for assessment of collagen and elastic fibers. ResultsIn both groups, some clinical improvement was achieved, which was statistically nonsignificant. However, histological examination showed increased collagen and decreased elastic fibers with reorganization after treatment. The image analyzer showed a significant quantitative increase in the mean area percent of collagen fibers and decrease in the mean area percent of elastic fibers. Side effects were nonsignificant, mostly pain during the session and pigmentary alterations. ConclusionAlthough the clinical improvement in the treated striae was nonsignificant, the histological improvement was significant, with few side effects. The use of different laser parameters with a long follow-up period may improve the clinical response.

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A mechanochemical model of striae distensae

Cited by 45 publications

References 26 publications

Possible extracardiac predictors of aortic dissection in Marfan syndrome

Possible extracardiac predictors of aortic dissection in Marfan syndrome

Improvement of skin condition in striae distensae: development, characterization and clinical efficacy of a cosmetic product containing <em>Punica granatum</em> seed oil and <em>Croton lechleri</em> resin extract

Histological and quantitative morphometric evaluation of striae distensae treated by long-pulsed 1064-nm Nd

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