A mechanistic updated overview on lycopene as potential anticancer agent

Özkan, Gülay; Günal-Köroğlu, Deniz; Karadağ, Ayşe; Çapanoğlu, Esra; Cardoso, Susana M.; Al-Omari, Basem; Călina, Daniela; Sharifi‐Rad, Javad; Cho, William C.

doi:10.1016/j.biopha.2023.114428

Cited by 28 publications

(24 citation statements)

References 76 publications

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“…Oxidative stress occurs as a result of an imbalance between free radicals and antioxidants found in our body (Calina et al, 2016;Salehi et al, 2019;Sharifi-Rad et al, 2021a;Sharifi-Rad et al, 2021c). Free radicals can be formed from dioxygen molecules, which contain unpaired electrons (Calina et al, 2016;Islam et al, 2021;Alshehri et al, 2022;Ozkan et al, 2023). It is precisely because of the unpaired electrons that oxygen molecules react easily with other molecules (Tsoukalas et al, 2019a;Tsoukalas et al, 2019b;Salehi et al, 2019;Sharifi-Rad et al, 2021b;Salehi et al, 2021).…”

Section: Phytate As Antioxidantmentioning

confidence: 99%

Phytates as a natural source for health promotion: A critical evaluation of clinical trials

et al. 2023

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Phytates are a type of organophosphorus compound produced in terrestrial ecosystems by plants. In plant feeds, phytic acid and its salt form, phytate, account for 60%–80% of total phosphorus. Because phytate is a polyanionic molecule, it can chelate positively charged cations such as calcium, iron, and zinc. Due to its prevalence in vegetal tissues and the fact that people consume plants, phytate was first considered a potential health benefit. This updated review aims to summarize the current data on the results of clinical trials of phytates on human health, highlighting both beneficial and undesirable effects. To obtain these updated data, published papers in electronic databases such as PubMed/MedLine, TRIP database, Wiley, Google Scholar, Baidu, and Scopus were searched. Study results have shown that phytate can have beneficial health effects such as antioxidant, anticancer potential and reduction of pathological calcifications in blood vessels and organs; but also, negative effects by reducing the absorption of minerals important for maintaining the homeostasis of the human body. According to these recent results derived from recent clinical studies, phytates may be a potential natural source for health benefits. To improve clinical efficacy and human health benefits, further dose-response studies are needed to determine effective therapeutic doses and potential interactions with conventional drugs.

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Section: Phytate As Antioxidantmentioning

confidence: 99%

Phytates as a natural source for health promotion: A critical evaluation of clinical trials

et al. 2023

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“…Tumors are composed of heterogeneous cells with the capacity to adapt dynamically their microenvironment by genetic/epigenetic changes and metabolic reprogramming [ 3 , 4 ]. The tumour cells are formed in the body due to metastasis, uncontrolled proliferation, lower immunity in the body, and resistance to apoptosis [ 5 ]. Apart from this, a higher level of oxidative stress exerted by reactive oxygen species (ROS) and/or reactive nitrogen species (RNS) is one of the major features of cancerous cells [ 6 – 8 ].…”

Section: Introductionmentioning

confidence: 99%

Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy

et al. 2023

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Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has a crucial role in cytoprotective response against oxidative stress, including cancer growth and progression and therapy resistance. For this reason, inhibitors of Nrf2 are new targets to be studied. Traditional plant-based remedies rich in phytochemicals have been used against human cancers and phenolic compounds are known for their chemopreventive properties. This comprehensive review offers an updated review of the role of phenolic compounds as anticancer agents due to their action on Nrf2 inhibition. In addition, the role of naturally-occurring bioactive anticancer agents are covered in the clinical applications of polyphenols as Nrf2 inhibitors.

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“…5 In addition, the main activity profiles of lycopene include anti-inflammatory, immunostimulatory, antihypertensive, and antiatherosclerotic effects, protecting cardiovascular and cerebrovascular vessels. 6 Thus, it is commonly used in nutritional supplements and functional foods and in the food industry as a natural colorant due to its color characteristics and safety, which has attracted widespread attention.…”

Section: Introductionmentioning

confidence: 99%

“…Lycopene is a carotenoid mainly found in mature red fruits and vegetables. , Lycopene is a straight chain hydrocarbon composed of 8 isoprene units, containing 11 conjugated double bonds and 2 unconjugated double bonds. , These structural features endow lycopene with strong antioxidant capacity, particularly as a quencher of singlet oxygen ( 1 O 2 ) that facilitates antioxidant defense in humans . In addition, the main activity profiles of lycopene include anti-inflammatory, immunostimulatory, antihypertensive, and antiatherosclerotic effects, protecting cardiovascular and cerebrovascular vessels . Thus, it is commonly used in nutritional supplements and functional foods and in the food industry as a natural colorant due to its color characteristics and safety, which has attracted widespread attention.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances on Key Enzymes of Microbial Origin in the Lycopene Biosynthesis Pathway

Du,

Sun,

Hui

et al. 2023

J. Agric. Food Chem.

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Lycopene is a common carotenoid found mainly in ripe red fruits and vegetables that is widely used in the food industry due to its characteristic color and health benefits. Microbial synthesis of lycopene is gradually replacing the traditional methods of plant extraction and chemical synthesis as a more economical and productive manufacturing strategy. The biosynthesis of lycopene is a typical multienzyme cascade reaction, and it is important to understand the characteristics of each key enzyme involved and how they are regulated. In this paper, the catalytic characteristics of the key enzymes involved in the lycopene biosynthesis pathway and related studies are first discussed in detail. Then, the strategies applied to the key enzymes of lycopene synthesis, including fusion proteins, enzyme screening, combinatorial engineering, CRISPR/Cas9-based gene editing, DNA assembly, and scaffolding technologies are purposefully illustrated and compared in terms of both traditional and emerging multienzyme regulatory strategies. Finally, future developments and regulatory options for multienzyme synthesis of lycopene and similar secondary metabolites are also discussed.

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A mechanistic updated overview on lycopene as potential anticancer agent

Cited by 28 publications

References 76 publications

Phytates as a natural source for health promotion: A critical evaluation of clinical trials

Phytates as a natural source for health promotion: A critical evaluation of clinical trials

Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy

Recent Advances on Key Enzymes of Microbial Origin in the Lycopene Biosynthesis Pathway

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