A mechanistic study on the antibacterial behavior of silver doped bioceramic

Ou, Shih-Fu; Chung, Ren-Jei; Lin, Li Hsiang; Chiang, Yi Chen; Huang, Chiung Fang; Ou, Keng Liang

doi:10.1016/j.jallcom.2014.12.158

Cited by 18 publications

(15 citation statements)

References 36 publications

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“…From the results it is also observed that E. coli showed higher pathogenic inhibition than S. aureus . This is because of a much thicker peptidoglycan layer for the distinctive S. aureus . However, no inhibition zones appeared on CCS ceramics which shows that there was no bactericidal activity of CCS ceramics.…”

Section: Resultsmentioning

confidence: 98%

“…This is because of a much thicker peptidoglycan layer for the distinctive S. aureus. 51 However, no inhibition zones appeared on CCS ceramics which shows that there was no bactericidal activity of CCS ceramics. Therefore, it was presumed that calcium silicate ceramic, which was synthesized using calcined eggshells powder as well as RHA as source materials, inhibited bacterial growth around the sample.…”

Section: Antimicrobial Activitymentioning

confidence: 96%

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A comparative study on in vitro behavior of calcium silicate ceramics synthesized from biowaste resources

et al. 2019

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Calcium silicate ceramics have received significant attention for biomedical applications for their excellent bioactivity and osteoconduction properties. Sol‐gel process is extensively used for the fabrication of calcium silicates. In sol‐gel process, calcium nitrate tetra hydrate (Ca(NO3)2·4H2O) and tetraethylorthosilicate (TEOS) are used as precursors. However, these precursors are expensive. The objective of this work was to compare in vitro behavior of calcium silicate (CaSiO3) produced using biowaste such as rice husk ash (RHA) and eggshells (coded; NCS) with CaSiO3 prepared using TEOS and Ca(NO3)2·4H2O (coded; CCS). Thermal investigation results revealed that the crystallization temperature for NCS is relatively lower (772°C) than for CCS (870°C). Bioactivity was studied in vitro using simulated body fluid (SBF) with respect to mineralization rate of hydroxyapatite. Mineralization of a greater hydroxyapatite was observed on NCS ceramics than CCS ceramics after incubation for 3, 7, 14 days in SBF solution, which was confirmed using X‐ray diffractometer, Fourier transform infrared spectroscopy, scanning electron microscopy‐energy dispersive spectroscopy. Degradation studies were conducted in Tris‐HCl solution and the test results revealed that NCS ceramics has lower dissolution rate than CCS ceramics. The antimicrobial assay has shown that NCS samples exhibit significant zone of inhibition against Escherichia coli and Staphylococcus aureus which confirmed that the CaSiO3 prepared from RHA and eggshell can prevent bacteria from adhering to the surface. In addition cell culture studies revealed that NCS ceramics possess good cytocompatibility with MG‐63 cells and significantly promoted cell proliferation.

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Section: Resultsmentioning

confidence: 98%

Section: Antimicrobial Activitymentioning

confidence: 96%

A comparative study on in vitro behavior of calcium silicate ceramics synthesized from biowaste resources

et al. 2019

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“…Sci. 2020, 10, x FOR PEER REVIEW 3 of 22 to implant loss and inevitable revised surgery [44,45]. The most reliable way to avoid bacterial adhesion is the incorporation of antibacterial agents such as silver, copper, zinc, mercury, tin, etc.…”

Section: Design Of Cad Modelsmentioning

confidence: 99%

“…It is shielded from the host immune system by the formation of bacterial biofilms making any antibiotic therapy ineffective. This circumstance leads to implant loss and inevitable revised surgery [44,45]. The most reliable way to avoid bacterial adhesion is the incorporation of antibacterial agents such as silver, copper, zinc, mercury, tin, etc.…”

Section: Introductionmentioning

confidence: 99%

Robocasting of Single and Multi-Functional Calcium Phosphate Scaffolds and Its Hybridization with Conventional Techniques: Design, Fabrication and Characterization

et al. 2020

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In this work, dense, porous, and, for the first time, functionally-graded bi-layer scaffolds with a cylindrical geometry were produced from a commercially available hydroxyapatite powder using the robocasting technique. The bi-layer scaffolds were made of a dense core part attached to a surrounding porous part. Subsequently, these bi-layer robocast scaffolds were joined with an outer shell of an antibacterial porous polymer layer fabricated by solvent casting/salt leaching techniques, leading to hybrid ceramic-polymer scaffolds. The antibacterial functionality was achieved through the addition of silver ions to the polymer layer. All the robocast samples, including the bi-layer ones, were first characterized through scanning electron microscopy observations, mechanical characterization in compression and preliminary bioactivity tests. Then, the hybrid bi-layer ceramic-polymer scaffolds were characterized through antimicrobial tests. After sintering at 1300 °C for 3 h, the compressive strengths of the structures were found to be equal to 29 ± 4 MPa for dense samples and 7 ± 4 MPa for lattice structures with a porosity of 34.1%. Bioactivity tests performed at 37 °C for 4 weeks showed that the precipitated layer on the robocast samples contained octacalcium phosphate. Finally, it was evidenced that the hybrid structure was effective in releasing antibacterial Ag+ ions to the surrounding medium showing its potential efficiency in limiting Staphylococcus aureus proliferation during surgery.

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“…The silver had a lower toxicity to human cells compared with copper, with the addition of copper also making it difficult to maintain both corrosion resistance and good antibacterial properties [40]. The purpose of adding silver is to utilize its antibacterial properties [41][42][43][44][45][46][47] in order to enable sterilization of the alloy, thereby enhancing the antibacterial properties of the biomaterial. To ensure the solid solution of the alloy with Ag, we used the Ti-Ag binary phase diagram [48] and formulated the alloy composition of Ti-12Nb-1Ag, before analyzing the antibacterial properties of Ti-12Nb-1Ag.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Properties and Corrosion Resistance of the Newly Developed Biomaterial, Ti–12Nb–1Ag Alloy

Chao

Chiu

et al. 2017

Metals

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Currently, the development of biomaterials has focused on having a low Young's modulus, biocompatibility, corrosion resistance, and antibacterial properties. Ti-Nb alloys have higher research value due to their excellent corrosion resistance and low Young's modulus. In recent years, the antibacterial properties of materials have been enhanced by the addition of Ag and Cu. Therefore, the corrosion resistance and antibacterial properties of the Ti-12Nb-1Ag alloy formulated in the current study were investigated and compared to those of commonly used Ti alloys, G2 pure Ti (ASTM B348 CP Grade 2), and Ti-6Al-4V, via electrochemical and E. coli antibacterial tests. Meanwhile, we also carried out a microstructural analysis to investigate the composition of the alloy. The results were as follows: (1) The electrochemical test demonstrated that Ti-12Nb-1Ag had a higher corrosion resistance than Ti-6Al-4V, which is similar to the properties of pure Ti. (2) The E. coli antibacterial test demonstrated that the sterilization rate of Ti-12Nb-1Ag was higher than that of the Ti-6Al-4V alloy and pure Ti. (3) The microstructural analysis revealed that Ti-12Nb-1Ag had an acicular martensite structure, with nano-Ag precipitates observed. Based on the results of the E. coli antibacterial test and the principles of sterilization of nano-precipitates and Ag, we inferred that the nano-Ag precipitates of Ti-12Nb-1Ag enhanced the antibacterial properties of the newly developed biomaterial, which is, namely, the Ti-12Nb-1Ag alloy.

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A mechanistic study on the antibacterial behavior of silver doped bioceramic

Cited by 18 publications

References 36 publications

A comparative study on in vitro behavior of calcium silicate ceramics synthesized from biowaste resources

A comparative study on in vitro behavior of calcium silicate ceramics synthesized from biowaste resources

Robocasting of Single and Multi-Functional Calcium Phosphate Scaffolds and Its Hybridization with Conventional Techniques: Design, Fabrication and Characterization

Antibacterial Properties and Corrosion Resistance of the Newly Developed Biomaterial, Ti–12Nb–1Ag Alloy

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