Abstract:Doxorubicin is a common chemotherapeutic treatment for ER+ breast tumors despite clinical reports demonstrating that ER+ patients respond less well to chemotherapy than ER-patients. Studies using ER+ breast cancer cell lines have shown that estrogen treatment counters chemotherapeutic effects, suggesting estrogen-induced signaling may confer chemotherapeutic resistance. However, little is known about whether and how chemotherapy affects estrogen/ER signaling, the effectors mediating chemotherapy's effects, and… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.