A mechanistic perspective on the role of phytoconstituents-based pharmacotherapeutics and their topical formulations in chronic wound management

Nanotechnology-driven wound healing potential of asiaticoside: a comprehensive review

“…Poor solubility may restrict drug dissolution in vivo , resulting in limited absorption, which can pharmacologically impair the therapeutic effectiveness of the medicine. 140 The drug's physicochemical characteristics, such as pKa, solubility, log P and molecular mass, are also significant when choosing the components for the topical delivery vehicle. 141,142 Many chemicals lack the physical parameters [such as low molecular weight, appropriate lipophilicity [log P (o/w = 1–3)], and low melting point] to passively penetrate the skin at therapeutic levels, restricting the topical delivery of drugs.…”