A mechanistic model for drug release in PLGA biodegradable stent coatings coupled with polymer degradation and erosion

Zhu, Xiaoxiang; Braatz, Richard D.

doi:10.1002/jbm.a.35357

Cited by 61 publications

(52 citation statements)

References 40 publications

(112 reference statements)

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“…In case when degradation and erosion is present in the model we assume that diffusion coefficient of the drug inside the fiber can be calculated according to (Zhu and Braatz 2015). The complete set of equations for describing the drug release through the PLGA polymer is summarized in Table 1 …”

Section: Degradation and Erosion Effect On Diffusion Within Plga Nanomentioning

confidence: 99%

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A Radial 1d Finite Element for Drug Release From Drug Loaded Nanofibers

Kojić¹,

Milošević²,

Simić³

et al. 2017

JSSCM

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The aim of this study was to investigate the release performance of an electrospun composite drug loaded nanofiber mat. Electrospun nanofiber mats are promising as drug carriers which offer site-specific delivery of drugs to a target in the human body and may be used for cancer therapy. The authors have formulated a simple radial 1D finite element, which is used to model diffusion within fibers releasing a drug to the surrounding medium discretized by continuum 3D finite elements. The numerical model includes degradation effects and hydrophobicity at the fibers/surroundings interface. For the purpose of experimental investigation, a poly(D,L-lacticco-glycolic acid) (PLGA) implant has been created at the Faculty of Technology and Metallurgy, University of Belgrade. The radial 1D element provides accurate predictions of the diffusion process and serves as an efficient tool for describing transport inside the polymer fiber and surrounding porous medium; which is illustrated through numerical examples.

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Section: Degradation and Erosion Effect On Diffusion Within Plga Nanomentioning

confidence: 99%

“…While macromolecular hydrophilic drugs are limited by diffusion through the pore space, relatively smaller hydrophobic drugs could diffuse through both the PLGA matrix and the pore space (Zhu et al 2015).…”

Section: Introductionmentioning

confidence: 99%

A Radial 1d Finite Element for Drug Release From Drug Loaded Nanofibers

Kojić¹,

Milošević²,

Simić³

et al. 2017

JSSCM

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“…The model for describing drug transport in the biodegradable PLGA coating was adapted from Ref. [32], and the model for drug transport and pharmacokinetics in the arterial wall was developed based on a previous study for biodurable coating [22], The integrated model provides a tool for evaluating PLGA-coated drug-eluting stents for intravascular drug delivery.…”

Section: Model Developmentmentioning

confidence: 99%

“…A degradable stent coating has been modeled by artificially switching the values of drug diffusivity in the coating reservoir based on a predefined drug concentration threshold [27], which does not mechanistically model the coating erosion process. While various models have been proposed for describing the in vitro drug release coupled with polymer degradation and/or erosion in PLGA drug delivery systems (for microspheres [28][29][30] and thin film stent coatings [31,32]), such mechanistic models have not been utilized to model the intravascular drug delivery from a PLGA stent coating.…”

mentioning

confidence: 99%

“…A mechanistic model for drug release in the PLGA coating is adopted that couples the drug diffusion to the PLGA degradation and erosion [32], and the adopted model is integrated with an arterial wall model where the drug pharmacoki netics in the arterial wall is modeled as a reversible binding pro cess [22]. The integrated model further incorporates drug internalization for cellular drug uptake, interstitial fluid flow, and strut embedment as model factors.…”

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confidence: 99%

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Modeling and Analysis of Drug-Eluting Stents With Biodegradable PLGA Coating: Consequences on Intravascular Drug Delivery

Zhu

Braatz

2014

Journal of Biomechanical Engineering

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Increasing interests have been raised toward the potential applications of biodegradable poly(lactic-co-glycolic acid) (PLGA) coatings for drug-eluting stents in order to improve the drug delivery and reduce adverse outcomes in stented arteries in patients. This article presents a mathematical model to describe the integrated processes of drug release in a stent with PLGA coating and subsequent drug delivery, distribution, and drug pharmacokinetics in the arterial wall. The integrated model takes into account the PLGA degradation and erosion, anisotropic drug diffusion in the arterial wall, and reversible drug binding. The model simulations first compare the drug delivery from a biodegradable PLGA coating with that from a biodurable coating, including the drug release profiles in the coating, average arterial drug levels, and arterial drug distribution. Using the model for the PLGA stent coating, the simulations further investigate drug internalization, interstitial fluid flow in the arterial wall, and stent embedment for their impact on drug delivery. Simulation results show that these three factors, while imposing little change in the drug release profiles, can greatly change the average drug concentrations in the arterial wall. In particular, each of the factors leads to significant and yet distinguished alterations in the arterial drug distribution that can potentially influence the treatment outcomes. The detailed integrated model provides insights into the design and evaluation of biodegradable PLGA-coated drug-eluting stents for improved intravascular drug delivery.

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Microstructured Biodegradable Fibers for Advanced Control Delivery

Shadman

Nguyen‐Dang

Gupta

et al. 2020

Adv Funct Materials

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Biodegradable polymers are increasingly employed at the heart of therapeutic devices. Particularly in the form of thin and elongated fibers, they offer an effective strategy for controlled release in a variety of biomedical configurations such as sutures, scaffolds, wound dressings, surgical or imaging probes, and smart textiles. So far however, the fabrication of fiber-based drug delivery systems has been unable to fulfill significant requirements of medicated fibers such as multifunctionality, adequate mechanical strength, drug loading capability, and complex release profiles of multiple substances. Here, a novel paradigm in the design and fabrication of microstructured biodegradable fibers with tailored mechanical properties and capable of predefined release patterns from multiple reservoirs is proposed. Different biodegradable polymers compatible with the scalable thermal drawing process are identified, and their release properties as thin films of various thicknesses in the fiber form are experimentally investigated and modeled. Multimaterial microstructured fibers with predictable complex release profiles of potentially different substances are then designed and fabricated. Moreover, the tunability of the mechanical properties via tailoring the drawing process parameters is demonstrated, as well as the ability to weave such fibers. This work establishes a novel platform for biodegradable microstructured fibers for applications in implants, sutures, wound dressing, or tissue scaffolds.

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A mechanistic model for drug release in PLGA biodegradable stent coatings coupled with polymer degradation and erosion

Cited by 61 publications

References 40 publications

A Radial 1d Finite Element for Drug Release From Drug Loaded Nanofibers

A Radial 1d Finite Element for Drug Release From Drug Loaded Nanofibers

Modeling and Analysis of Drug-Eluting Stents With Biodegradable PLGA Coating: Consequences on Intravascular Drug Delivery

Microstructured Biodegradable Fibers for Advanced Control Delivery

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