A Mechanism of the Acceleration of Lipid Peroxide Formation in Liver Homogenates and Subcellular Fractions of Vitamin E-Deficient Mice

Ultracytochemical Changes in the Distribution of Acid Phosphatase in the Liver Cells of Vitamin E Deficient and Vitamin E Supplemented Rats

“…The rate of lipid peroxidation was considerably higher in the liver homogenates of vit. E deficient rats than that of the normal rats (12,45). Lipid soluble fluorescent pigment is known to increase during vit.…”

“…It is also thought that the increase in lipid peroxidation in the vit. E deficient liver is a subsequent result of membrane alteration, rather than its cause (12). Vit.…”

“…Unsaturated fatty acid, catalyzer, cofactor and ascorbate, and antioxidants (such as vit. E) are involved in the process of lipid peroxidation, and its rate depends on the quantitative balance of these factors (12). Irregular or tail-like structures of positive lysosomes seen in the hepatic parenchymal cells suggest a wrapping mechanism (37).…”

“…Vit. E is known to prevent peroxidation of unsaturated lipids (40) by preserving the normal structure of the membranes (12). Unsaturated fatty acid, catalyzer, cofactor and ascorbate, and antioxidants (such as vit.…”

Effects of Phenobarbital Administration on Levels of Physiological Antioxidants in Rat Liver

“…However, the effect of sub stances which induce lipid peroxidation on the endogenous levels of naturally occurring anti oxidants has not been thoroughly explored. Previous studies from this laboratory (12,13) and others (10,18) have demonstrated that phénobarbital (PB) administration increased hepatic lipid peroxidation and produced a fatty liver. The present study was conducted to determine whether PB administration increased lipid peroxidation by altering the hepatic levels of naturally occurring antioxidants.…”