A mechanism of raft formation on both plasma membrane layers

Sornbundit, Kan; Modchang, Charin; Triampo, Wannapong; Triampo, Darapond; Nuttavut, Narin

doi:10.1051/epjap/2013130210

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…32 Active lipid recycling has also been shown through coarse-grained simulations of phase-field models to lead to nanoscale domain structures. [33][34][35] There has also been a proposal that hybrid lipids with one fully saturated chain and one partially unsaturated chain may act as a linactant (two-dimensional analog of surfactant) that prefer to locate at the boundaries between regions rich in saturated lipids (and cholesterol) and regions rich in unsaturated lipids. 36 The linactants therefore produce two-dimensional microemulsions with a nanoscale domain structure.…”

Section: Introductionmentioning

confidence: 99%

Combined effect of cortical cytoskeleton and transmembrane proteins on domain formation in biomembranes

Sikder

Stone

Kumar

et al. 2014

The Journal of Chemical Physics

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We investigate the combined effects of transmembrane proteins and the subjacent cytoskeleton on the dynamics of phase separation in multicomponent lipid bilayers using computer simulations of a particle-based implicit solvent model for lipid membranes with soft-core interactions. We find that microphase separation can be achieved by the protein confinement by the cytoskeleton. Our results have relevance to the finite size of lipid rafts in the plasma membrane of mammalian cells.

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Section: Introductionmentioning

confidence: 99%

Combined effect of cortical cytoskeleton and transmembrane proteins on domain formation in biomembranes

Sikder

Stone

Kumar

et al. 2014

The Journal of Chemical Physics

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“…They showed that the experimental results could be fitted quantitatively with simulation predictions of the Foret model. Sornbundit et al [174] applied the Foret model to a system of two coupled monolayers, where phase separation occurs on one side only, and show that this leads to domain formation on both sides. Garcke et al [170] presented a detailed mathematical analysis of the Foret model and pointed out the relation to the Ohta-Kawasaki functional.…”

Section: Membrane Recyclingmentioning

confidence: 99%

Physical mechanisms of micro- and nanodomain formation in multicomponent lipid membranes

Schmid

2017

Biochimica et Biophysica Acta (BBA) - Biomembranes

106

112

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This article summarizes a variety of physical mechanisms proposed in the literature, which can generate micro-and nanodomains in multicomponent lipid bilayers and biomembranes. It mainly focusses on lipid-driven mechanisms that do not involve direct protein-protein interactions. Specifically, it considers (i) equilibrium mechanisms based on lipidlipid phase separation such as critical cluster formation close to critical points, and multiple domain formation in curved geometries, (ii) equilibrium mechanisms that stabilize two-dimensional microemulsions, such as the effect of linactants and the effect of curvature-composition coupling in bilayers and monolayers, and (iii) non-equilibrium mechanisms induced by the interaction of a biomembrane with the cellular environment, such as membrane recycling and the pinning effects of the cytoplasm. Theoretical predictions are discussed together with simulations and experiments. The presentation is guided by the theory of phase transitions and critical phenomena, and the appendix summarizes the mathematical background in a concise way within the framework of the Ginzburg-Landau theory.

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“…17 The kinetics of phase separation in multicomponent lipid membranes has been the subject of many experimental, theoretical and computational studies during the last decade. [6][7][8][18][19][20][21][22][23][24][25] Interleaet coupling is typically assumed in the theoretical and computational studies. Consequently, domain registration is observed because of the inception of the phase separation process.…”

Section: Introductionmentioning

confidence: 99%

Kinetics of domain registration in multicomponent lipid bilayer membranes

et al. 2014

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The kinetics of registration of lipid domains in the apposing leaflets of symmetric bilayer membranes is investigated via systematic dissipative particle dynamics simulations. The decay of the distance between the centres of mass of the domains in the apposing leaflets is almost linear during early stages, and then becomes exponential during late times. The time scales of both linear and exponential decays are found to increase with decreasing the strength of interleaflet coupling. The ratio between the time scales of the exponential and linear regimes decreases with increasing the domain size, implying that the decay of the distance between the domains centres of mass is essentially linear for large domains. These numerical results are largely in agreement with the recent theoretical predictions of Han and Haataja [Soft Matter (2013) 9:2120-2124]. We also found that the domains become elongated during the registration process.

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A mechanism of raft formation on both plasma membrane layers

Cited by 3 publications

References 24 publications

Combined effect of cortical cytoskeleton and transmembrane proteins on domain formation in biomembranes

Combined effect of cortical cytoskeleton and transmembrane proteins on domain formation in biomembranes

Physical mechanisms of micro- and nanodomain formation in multicomponent lipid membranes

Kinetics of domain registration in multicomponent lipid bilayer membranes

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