A mechanically adaptive hydrogel neural interface based on silk fibroin for high-efficiency neural activity recording

Ding, Jie; Chen, Zhihong; Liu, Xiaoyin; Tian, Yuan; Jiang, Ji; Qiao, Zi; Zhang, Yusheng; Xiao, Zhu; Wei, Dan; Sun, Jing; Luo, Fang; Zhou, Liangxue; Fan, Hongsong

doi:10.1039/d2mh00533f

Cited by 26 publications

(28 citation statements)

References 47 publications

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“…The results in Figure S6 showed that the adhesion strength of GUT-PP hydrogels exposed to water and blood (∼10 kPa) decreased compared with that in air (∼16 kPa), due to the formation of a hydrated layer at the hydrogel–tissue interface, while the adhesive strength gap was further widened when the hydrogels were exposed to grease, which may be attributed to the self-lubricating effect of the grease. Although the adhesion strength decreased upon exposure to physiological media, it still satisfied the bioelectronic requirements. , The effect of temperature on the adhesion strength was further investigated, and the adhesion strength of GUT-PP hydrogel was 6.8 kPa at room temperature, which increased to 10.1 kPa at body temperature with an interfacial toughness of 30.9 J m –2 (Figures I and S7), which is comparable to that of a previously reported nanoparticle-based adhesive . As indicated in Figure S6, the GUT-PP hydrogel adhered tightly to the warm skin of a newborn rat and adapted to skin deformations during movements, while could also be removed without harming the skin and leaving residues.…”

Section: Resultssupporting

confidence: 72%

“…Although the adhesion strength decreased upon exposure to physiological media, it still satisfied the bioelectronic requirements. 6,42 The effect of temperature on the adhesion strength was further investigated, and the adhesion strength of GUT-PP hydrogel was 6.8 kPa at room temperature, which increased to 10.1 kPa at body temperature with an interfacial toughness of 30.9 J m −2 (Figures 2I and S7), which is comparable to that of a previously reported nanoparticle-based adhesive. 43 indicated in Figure S6, the GUT-PP hydrogel adhered tightly to the warm skin of a newborn rat and adapted to skin deformations during movements, while could also be removed without harming the skin and leaving residues.…”

Section: ■ Introductionsupporting

confidence: 74%

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Hydrogel-Integrated Multimodal Response as a Wearable and Implantable Bidirectional Interface for Biosensor and Therapeutic Electrostimulation

Sun

Xiao

et al. 2023

ACS Appl. Mater. Interfaces

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A hydrogel that fuses long-term biologic integration, multimodal responsiveness, and therapeutic functions has received increasing interest as a wearable and implantable sensor but still faces great challenges as an all-in-one sensor by itself. Multiple bonding with stimuli response in a biocompatible hydrogel lights up the field of soft hydrogel interfaces suitable for both wearable and implantable applications. Given that, we proposed a strategy of combining chemical cross-linking and stimuli-responsive physical interactions to construct a biocompatible multifunctional hydrogel. In this hydrogel system, ureidopyrimidinone/tyramine (Upy/Tyr) difunctionalization of gelatin provides abundant dynamic physical interactions and stable covalent cross-linking; meanwhile, Tyr-doped poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) acts as a conductive filler to establish electrical percolation networks through enzymatic chemical cross-linking. Thus, the hydrogel is characterized with improved conductivity, conformal biointegration features (i.e., high stretchability, rapid self-healing, and excellent tissue adhesion), and multistimuli-responsive conductivity (i.e., temperature and urea). On the basis of these excellent performances, the prepared multifunctional hydrogel enables multimodal wearable sensing integration that can simultaneously track both physicochemical and electrophysiological attributes (i.e., motion, temperature, and urea), providing a more comprehensive monitoring of human health than current wearable monitors. In addition, the electroactive hydrogel here can serve as a bidirectional neural interface for both neural recording and therapeutic electrostimulation, bringing more opportunities for nonsurgical diagnosis and treatment of diseases.

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Section: Resultssupporting

confidence: 72%

Section: ■ Introductionsupporting

confidence: 74%

Hydrogel-Integrated Multimodal Response as a Wearable and Implantable Bidirectional Interface for Biosensor and Therapeutic Electrostimulation

Sun

Xiao

et al. 2023

ACS Appl. Mater. Interfaces

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“…The pristine PAAm hydrogel shows a 3D uniform microporous structure. The average pore size of this cell-like network is 68 μm 2 . The interconnected porous cell-like structure remains intact with the introduction of silver nanocubes; however, the average pore size increases slightly up to 77 μm 2 .…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Z projections were obtained, and cells were counted manually by an investigator blind to the experimental condition. Cell counts are presented as the number of cells per mm 2 .…”

Section: ■ Conclusionmentioning

confidence: 99%

“…The acquisition of neural signals from the brain cortex has always been of high relevance in the field of neuroscience. 1,2 Moreover, the extension of the electrophysiological recording/ stimulation in the brain cortex from days to years may help understand brain processes and neurological diseases and disorders. 3−5 Compared to electroencephalography (EEG), electrocorticography (ECoG) can improve the spatial specificity, amplitude, and signal-to-noise ratio since the electrodes are placed directly on the cortical surface.…”

Section: ■ Introductionmentioning

confidence: 99%

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In Vivo Chronic Brain Cortex Signal Recording Based on a Soft Conductive Hydrogel Biointerface

Rinoldi

Ziai

Zargarian

et al. 2022

ACS Appl. Mater. Interfaces

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In neuroscience, the acquisition of neural signals from the brain cortex is crucial to analyze brain processes, detect neurological disorders, and offer therapeutic brain−computer interfaces. The design of neural interfaces conformable to the brain tissue is one of today's major challenges since the insufficient biocompatibility of those systems provokes a fibrotic encapsulation response, leading to an inaccurate signal recording and tissue damage precluding long-term/permanent implants. The design and production of a novel soft neural biointerface made of polyacrylamide hydrogels loaded with plasmonic silver nanocubes are reported herein. Hydrogels are surrounded by a silicon-based template as a supporting element for guaranteeing an intimate neural-hydrogel contact while making possible stable recordings from specific sites in the brain cortex. The nanostructured hydrogels show superior electroconductivity while mimicking the mechanical characteristics of the brain tissue. Furthermore, in vitro biological tests performed by culturing neural progenitor cells demonstrate the biocompatibility of hydrogels along with neuronal differentiation. In vivo chronic neuroinflammation tests on a mouse model show no adverse immune response toward the nanostructured hydrogel-based neural interface. Additionally, electrocorticography acquisitions indicate that the proposed platform permits long-term efficient recordings of neural signals, revealing the suitability of the system as a chronic neural biointerface.

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Challenges and Opportunities of Implantable Neural Interfaces: From Material, Electrochemical and Biological Perspectives

Zeng

Huang

2023

Adv Funct Materials

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The desirable implantable neural interfaces can accurately record bioelectrical signals from neurons and regulate neural activities with high spatial/time resolution, facilitating the understanding of neuronal functions and dynamics. However, the electrochemical performance (impedance, charge storage/injection capacity) is limited with the miniaturization and integration of neural electrodes. The “crosstalk” caused by the uneven distribution of elctric field leads to lower electrical stimulation/recording efficiency. The mismatch between stiff electrodes and soft tissues exacerbates the inflammatory responses, thus weakening the transmission of signals. Though remarkable breakthroughs have been made through the incorporation of optimizing electrode design and functionalized nanomaterials, the chronic stability, and long‐term activity in vivo of the neural electrodes still need further development. In this review, the neural interface challenges mainly on electrochemistry and biology are discussed, followed by summarizing typical electrode optimization technologies and exploring recent advances in the application of nanomaterials, based on traditional metallic materials, emerging 2D materials, conducting polymer hydrogels, etc., for enhancing neural interfaces. The strategies for improving the durability including enhanced adhesion and minimized inflammatory response, are also summarized. The promising directions are finally presented to provide enlightenment for high‐performance neural interfaces in future, which will promote profound progress in neuroscience research.

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A mechanically adaptive hydrogel neural interface based on silk fibroin for high-efficiency neural activity recording

Abstract: Flexible non-transient electrical platform that can realize bidirectional neural communication from the living tissues is of great interest in neuroscience to better understanding of basic neuroscience and nondrug therapy diseases...

Cited by 26 publications

References 47 publications

Hydrogel-Integrated Multimodal Response as a Wearable and Implantable Bidirectional Interface for Biosensor and Therapeutic Electrostimulation

Hydrogel-Integrated Multimodal Response as a Wearable and Implantable Bidirectional Interface for Biosensor and Therapeutic Electrostimulation

In Vivo Chronic Brain Cortex Signal Recording Based on a Soft Conductive Hydrogel Biointerface

Challenges and Opportunities of Implantable Neural Interfaces: From Material, Electrochemical and Biological Perspectives

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