A meal rich in palm oil or butter modifies the sphingolipid profile of postprandial triglyceride-rich lipoproteins from type 2 diabetic women

Boulet, Marie Michèle; Calzada, Catherine; Pettazzoni, Magali; Lelekov-Boissard, Taïssia; Buisson, C.; Filippo, Mathilde Di; Durand, Annie; Lambert‐Porcheron, Stéphanie; Nazare, Julie‐Anne; Moulin, Philippe; Michalski, Marie‐Caroline; Cheillan, David

doi:10.1016/j.biochi.2022.07.003

Cited by 3 publications

(4 citation statements)

References 38 publications

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“…Intestine-derived lipoproteins, i.e., CM, the major triglyceride-rich lipoproteins (TGRL) and HDL, are released into the bloodstream via the lymph. As described in the present review, SFA consumption may lead to increased concentrations of Cer in TGRL ( 28 ) and HDL ( 33 ). Supplementation with milk polar lipids may result in decreased concentrations of SM and Cer in CM ( 27 ).…”

Section: Discussionmentioning

confidence: 62%

“…Sphingolipids are mostly transported in the bloodstream within lipoproteins ( 5 ) and are present at different amounts in the lipoprotein classes: VLDL, LDL and HDL ( 4 , 24 – 26 ). To get a deeper insight into the dietary lipid-induced modifications of plasma sphingolipids, it is of key importance to determine the concentrations of sphingolipid classes into intestine-derived lipoproteins ( 27 , 28 ). The intestine produces triglyceride-rich lipoproteins (TGRL), including chylomicrons, apoB48-containing VLDL ( 29 ), but also apoA-I, the principal apolipoprotein of HDL ( 30 , 31 ).…”

Section: Dietary Fatty Acids and Circulating Sphingolipidsmentioning

confidence: 99%

“…The intestine produces triglyceride-rich lipoproteins (TGRL), including chylomicrons, apoB48-containing VLDL ( 29 ), but also apoA-I, the principal apolipoprotein of HDL ( 30 , 31 ). A randomized parallel group study in 30 obese type 2 diabetic patients compared the effects of a single fat meal on postprandial TGRL collected 4 h after ingestion of 20 g lipids from a hazelnut-cocoa palm oil-rich spread or butter ( 28 ); among fatty acids in each fat source, palmitic acid represented 33 mol% and 42 mol% of total fatty acids respectively. Following the consumption of either meal rich in SFA, total Cer concentrations were higher in postprandial TGRL compared to fasting TGRL, regardless of the saturated fats consumed.…”

Section: Dietary Fatty Acids and Circulating Sphingolipidsmentioning

confidence: 99%

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Role of circulating sphingolipids in lipid metabolism: Why dietary lipids matter

et al. 2023

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Sphingolipids are structural components of cell membranes and lipoproteins but also act as signaling molecules in many pathophysiological processes. Although sphingolipids comprise a small part of the plasma lipidome, some plasma sphingolipids are recognized as implicated in the development of metabolic diseases and cardiovascular diseases. Plasma sphingolipids are mostly carried out into lipoproteins and may modulate their functional properties. Lipids ingested from the diet contribute to the plasma lipid pool besides lipids produced by the liver and released from the adipose tissue. Depending on their source, quality and quantity, dietary lipids may modulate sphingolipids both in plasma and lipoproteins. A few human dietary intervention studies investigated the impact of dietary lipids on circulating sphingolipids and lipid-related cardiovascular risk markers. On the one hand, dietary saturated fatty acids, mainly palmitic acid, may increase ceramide concentrations in plasma, triglyceride-rich lipoproteins and HDL. On the other hand, milk polar lipids may decrease some molecular species of sphingomyelins and ceramides in plasma and intestine-derived chylomicrons. Altogether, different dietary fatty acids and lipid species can modulate circulating sphingolipids vehicled by postprandial lipoproteins, which should be part of future nutritional strategies for prevention of cardiovascular diseases.

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Section: Discussionmentioning

confidence: 62%

Section: Dietary Fatty Acids and Circulating Sphingolipidsmentioning

confidence: 99%

Section: Dietary Fatty Acids and Circulating Sphingolipidsmentioning

confidence: 99%

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Role of circulating sphingolipids in lipid metabolism: Why dietary lipids matter

et al. 2023

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“…Analyses of sphingolipids were performed following a method described by Boulet al [ 20 ]. Briefly, a one-phase lipid extraction with chloroform/methanol (1:2) was performed with 10 µL of plasma.…”

Section: Methodsmentioning

confidence: 99%

Functional and Molecular Characterization of New SPTLC1 Missense Variants in Patients with Hereditary Sensory and Autonomic Neuropathy Type 1 (HSAN1)

Rochat,

Blavier,

Ruet

et al. 2024

Genes

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Hereditary sensory and autonomic neuropathy type 1 is an autosomal dominant neuropathy caused by the SPTLC1 or SPTLC2 variants. These variants modify the preferred substrate of serine palmitoyl transferase, responsible for the first step of de novo sphingolipids synthesis, leading to accumulation of cytotoxic deoxysphingolipids. Diagnosis of HSAN1 is based on clinical symptoms, mainly progressive loss of distal sensory keep, and genetic analysis. Aim: Identifying new SPTLC1 or SPTLC2 “gain-of-function” variants raises the question as to their pathogenicity. This work focused on characterizing six new SPTLC1 variants using in silico prediction tools, new meta-scores, 3D modeling, and functional testing to establish their pathogenicity. Methods: Variants from six patients with HSAN1 were studied. In silico, CADD and REVEL scores and the 3D modeling software MITZLI were used to characterize the pathogenic effect of the variants. Functional tests based on plasma sphingolipids quantification (total deoxysphinganine, ceramides, and dihydroceramides) were performed by tandem mass spectrometry. Results: In silico predictors did not provide very contrasting results when functional tests discriminated the different variants according to their impact on deoxysphinganine level or canonical sphingolipids synthesis. Two SPTLC1 variants were newly described as pathogenic: SPTLC1 NM_006415.4:c.998A>G and NM_006415.4:c.1015G>A. Discussion: The combination of the different tools provides arguments to establish the pathogenicity of these new variants. When available, functional testing remains the best option to establish the in vivo impact of a variant. Moreover, the comprehension of metabolic dysregulation offers opportunities to develop new therapeutic strategies for these genetic disorders.

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Effects of PM2.5 and high-fat diet interaction on blood glucose metabolism in adolescent male Wistar rats: A serum metabolomics analysis based on ultra-high performance liquid chromatography/mass spectrometry

Li,

Ni,

Sun

et al. 2023

Ecotoxicology and Environmental Safety

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A meal rich in palm oil or butter modifies the sphingolipid profile of postprandial triglyceride-rich lipoproteins from type 2 diabetic women

Cited by 3 publications

References 38 publications

Role of circulating sphingolipids in lipid metabolism: Why dietary lipids matter

Role of circulating sphingolipids in lipid metabolism: Why dietary lipids matter

Functional and Molecular Characterization of New SPTLC1 Missense Variants in Patients with Hereditary Sensory and Autonomic Neuropathy Type 1 (HSAN1)

Effects of PM2.5 and high-fat diet interaction on blood glucose metabolism in adolescent male Wistar rats: A serum metabolomics analysis based on ultra-high performance liquid chromatography/mass spectrometry

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