A mathematical modeling approach to risk assessment for normal and anemic women chronically exposed to carbon monoxide from biomass-fueled cookstoves

Bruce, Eugene N.; Bruce, Margaret C.; Erupaka-Chada, Kinnera

doi:10.1152/japplphysiol.00040.2011

Cited by 4 publications

(2 citation statements)

References 38 publications

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“…Acute exposure to high levels of CO can cause serious neuropsychiatric damage and can be lethal. In addition, chronic exposure to CO can have important health consequences, especially in those with underlying conditions such as anemia, asthma, and coronary artery disease, which impair tissue oxygenation [ 20 ]. Given the high burden of disease attributable to biomass fuel use, there is considerable interest in the design of interventions, such as chimney stoves, for reducing exposures to indoor biomass smoke.…”

Section: Introductionmentioning

confidence: 99%

A cross-sectional study of determinants of indoor environmental exposures in households with and without chronic exposure to biomass fuel smoke

et al. 2014

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BackgroundBurning biomass fuels indoors for cooking is associated with high concentrations of particulate matter (PM) and carbon monoxide (CO). More efficient biomass-burning stoves and chimneys for ventilation have been proposed as solutions to reduce indoor pollution. We sought to quantify indoor PM and CO exposures in urban and rural households and determine factors associated with higher exposures. A secondary objective was to identify chronic vs. acute changes in cardiopulmonary biomarkers associated with exposure to biomass smoke.MethodsWe conducted a census survey followed by a cross-sectional study of indoor environmental exposures and cardiopulmonary biomarkers in the main household cook in Puno, Peru. We measured 24-hour indoor PM and CO concentrations in 86 households. We also measured PM2.5 and PM10 concentrations gravimetrically for 24 hours in urban households and during cook times in rural households, and generated a calibration equation using PM2.5 measurements.ResultsIn a census of 4903 households, 93% vs. 16% of rural vs. urban households used an open-fire stove; 22% of rural households had a homemade chimney; and <3% of rural households participated in a national program encouraging installation of a chimney. Median 24-hour indoor PM2.5 and CO concentrations were 130 vs. 22 μg/m3 and 5.8 vs. 0.4 ppm (all p<0.001) in rural vs. urban households. Having a chimney did not significantly reduce median concentrations in 24-hour indoor PM2.5 (119 vs. 137 μg/m3; p=0.40) or CO (4.6 vs. 7.2 ppm; p=0.23) among rural households with and without chimneys. Having a chimney did not significantly reduce median cook-time PM2.5 (360 vs. 298 μg/m3, p=0.45) or cook-time CO concentrations (15.2 vs. 9.4 ppm, p=0.23). Having a thatched roof (p=0.007) and hours spent cooking (p=0.02) were associated with higher 24-hour average PM concentrations. Rural participants had higher median exhaled CO (10 vs. 6 ppm; p=0.01) and exhaled carboxyhemoglobin (1.6% vs. 1.0%; p=0.04) than urban participants.ConclusionsIndoor air concentrations associated with biomass smoke were six-fold greater in rural vs. urban households. Having a homemade chimney did not reduce environmental exposures significantly. Measures of exhaled CO provide useful cardiopulmonary biomarkers for chronic exposure to biomass smoke.

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Section: Introductionmentioning

confidence: 99%

A cross-sectional study of determinants of indoor environmental exposures in households with and without chronic exposure to biomass fuel smoke

et al. 2014

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“…Mean CO exposures over a 24-hour period have been measured at 2-50 parts per million (ppm) among households that burn solid fuel, and often exceed the 9 ppm standard (in an 8-hour period) set by the WHO [34, 35]. CO levels in homes using solid fuels are sometimes high enough to result in blood carboxyhemoglobin (COHb) levels between 2.5% and 16%, with upper limits comparable to levels measured in heavy smokers [36, 37, 38 ].…”

Section: Introductionmentioning

confidence: 99%

Genetic modification of the effect of maternal household air pollution exposure on birth weight in Guatemalan newborns

Thompson¹,

Yousefi²,

Peñaloza³

et al. 2014

Reproductive Toxicology

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Low birth weight is associated with exposure to air pollution during pregnancy. The purpose of this study was to evaluate whether null polymorphisms of Glutathione S-transferases (GSTs), specifically GSTM1 and GSTT1 genes in infants or mothers, modifies the association between high exposures to household air pollution (HAP) from cooking fires and birth weight. Pregnant women in rural Guatemala were randomized to receive a chimney stove or continue to use open fires for cooking. Newborns were measured within 48 hours of birth. 132 mother-infant pairs provided infant genotypes (n=130) and/or maternal genotypes (n=116). Maternal null GSTM1 was associated with a 144 gram (95% CI: -291, 1) and combined maternal/infant null GSTT1 was associated with a 155 gram (95% CI -303, -8) decrease in birth weight. Although there was a trend toward higher birth weights with increasing number of expressed GST genes, the effect modification by chimney stove use was not demonstrated.

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Risk analysis of air pollution correlates with socioeconomic and heart diseases

Mishra,

Behera,

Jena

et al. 2024

Spatial Modeling of Environmental Pollution and Ecological Risk

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A mathematical modeling approach to risk assessment for normal and anemic women chronically exposed to carbon monoxide from biomass-fueled cookstoves

Abstract: Bruce EN, Bruce MC, Erupaka-Chada K. A mathematical modeling approach to risk assessment for normal and anemic women chronically exposed to carbon monoxide from biomass-fueled cookstoves.

Cited by 4 publications

References 38 publications

A cross-sectional study of determinants of indoor environmental exposures in households with and without chronic exposure to biomass fuel smoke

A cross-sectional study of determinants of indoor environmental exposures in households with and without chronic exposure to biomass fuel smoke

Genetic modification of the effect of maternal household air pollution exposure on birth weight in Guatemalan newborns

Risk analysis of air pollution correlates with socioeconomic and heart diseases

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