A mathematical model of venous neointimal hyperplasia formation

Budu-Grajdeanu, Paula; Schugart, Richard C.; Friedman, Avner; Valentine, Christopher; Agarwal, Anil; Rovin, Brad H.

doi:10.1186/1742-4682-5-2

Cited by 49 publications

(36 citation statements)

References 32 publications

(40 reference statements)

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“…AVF maturation is the ability of the inflow artery and the outflow vein to respond to the increased blood flow that occurs upon anastomosis of the artery and vein. A healthy response to the anastomosis is an increase in blood flow and corresponding increase in shear stress [11] which stimulates the endothelial cells to release nitric oxide (NO) and other vasodilatory substances [12]. The main purpose of this review was to discuss the maturation of AVF and endothelial dysfunction in an advance kidney disease.…”

Section: Introductionmentioning

confidence: 99%

An overview of AVF maturation and endothelial dysfunction in an advanced renal failure

et al. 2017

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Life expectancy in patient with established kidney failure is considerably shortened with worsening quality of life. Through the provision of renal replacement therapy, survival and quality of life of advanced renal disease patients can be markedly improved. Haemodialysis and peritoneal dialysis are the treatment modalities in patients with end-stage renal disease. The efficiency of haemodialysis treatment relies on the functional status of vascular access. Vascular access and its related problems represent the main factors that determine a rise in the rate of incidence of the disease among haemodialysis patients and, consequently, a rise in the healthcare expenses. Arteriovenous fistula is the most efficient method, as it has a low risk of infection and mortality, and can ensure long-term functional access. However, maturation of an arteriovenous fistula is a complex process and is not well understood; significant numbers of arteriovenous fistula fail to develop sufficiently prior to their use for haemodialysis due to either lack of vessel maturation or spontaneous thrombosis. There are multiple blood markers and human factors that contribute to the maturation of fistula. Endothelial function is one of the most important determinants of arteriovenous fistula maturation. Early fistula failure is usually due to thrombosis which can be triggered by haematoma, by low flow rates resulting from low blood pressure, or by a hypercoagulable state. Impairment of endothelial function is associated with decreased arterial remodelling and final venous lumen diameter. Arteriovenous fistula anastomoses need early proliferation of endothelial cells to restore the barrier, permeability, and biochemical monitoring roles of endothelial cells in managing vascular repair, local thrombosis, neointimal hyperplasia, and inflammation. The purpose of this review was to discuss the maturation of AVF and endothelial dysfunction.

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Section: Introductionmentioning

confidence: 99%

An overview of AVF maturation and endothelial dysfunction in an advanced renal failure

et al. 2017

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“…Stenosis refers to the reduction in the diameter of the access which impedes flow through the access. This is usually due to neo-intimal hyperplasia induced by trauma and turbulent blood flow [1][2][3]. Significant stenosis in the access leads to ineffective dialysis with decrease life of access [4] and eventually, hypertension with its attending complications.…”

Section: Discussionmentioning

confidence: 99%

An Examination of the Dark Triad Constructs with Regard to Prosocial Behavior

Palmer¹,

Tackett²

2018

Acta Psychopathol

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“…9,10 Other less common complications of prosthetic accesses include; steal syndrome, seromas, aneurysm formation, central vein stenosis and bleeding. 11 Thrombosis seems to occur soon after implantation due to technical problem, with a clot typically forming at the surface of the graft when it is first exposed to blood.…”

Section: Complications Associated With Prosthetic Graftsmentioning

confidence: 99%