A mathematical model for bone healing predictions under the ultrasound effect

Vavva, Maria G.; Grivas, Konstantinos; Polyzos, D.; Fotiadis, Dimitrios I.; Carlier, Aurélie; Geris, Liesbet; Oosterwyck, Hans Van

doi:10.1109/esucb.2015.7169909

Cited by 3 publications

(7 citation statements)

References 12 publications

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“…Although several computational studies have investigated the underlying mechanisms of cell activities and angiogenesis (Shefelbine et al 2005, Peiffer et al 2011), in Vavva et al (2015 we presented a bioregulatory model which accounts for the effect of ultrasound on angiogenesis and bone healing mechanisms. Ultrasound was modeled to primarily affect VEGF transport.…”

Section: Discussionmentioning

confidence: 99%

“…Angiogenesis plays significant role in bone healing since it re-establishes blood circulation at the fracture region which limits ischaemic necrosis and enhances bone repair. Several growth factors such as the transforming growth factor (TGF), bone morphogenetic protein (BMP), fibroblast growth factor (FGF), and vascular endothelial growth factor (VEGF) regulate the vascularization process having direct or indirect osteogenic and angiogenic influence (Vavva et al 2015). However, the VEGF pathway is considered to be the key regulator in the neoangiogenesis and revascularization of the fracture region.…”

Section: Ossification Process and Angiogenesis Predictions In Bone Hementioning

confidence: 99%

“…9. Spatiotemporal evolution of fibrous tissue, cartilage and bone matrix density: (a) under the presence of ultrasound, (b) without the presence of ultrasound (Vavva et al 2015).…”

Section: Ossification Process and Angiogenesis Predictions In Bone Hementioning

confidence: 99%

“…Nevertheless, these models do not account for the effect of ultrasound on the fracture healing mechanisms and angiogenesis. To this end, in (Vavva et al 2015), we presented a deterministic hybrid model for bone healing and angiogenesis predictions under the impact of ultrasound. The proposed mathematical model was based on the model of (Peiffer et al 2011) extended by: (a) including an additional equation describing the spatiotemporal evolution of ultrasound acoustic pressure, and (b) modifying the equation that describes the spatiotemporal evolution of VEGF.…”

Section: Ossification Process and Angiogenesis Predictions In Bone Hementioning

confidence: 99%

“…Emphasis is given on the experimental and numerical studies of our research group over the last decade which investigate bone healing and osteoporosis evolution using QUS , Protopappas et al 2007, Vavva et al 2008a, Potsika et al 2014, Vavva et al 2015, Potsika et al 2016a.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Ultrasonic evaluation of intact, healing and osteoporotic long bones

Potsika¹,

Protopappas²,

Grivas³

et al. 2016

J Serb Soc Comp Mech

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Quantitative ultrasound (QUS) has been introduced in recent years for the comprehensive noninvasive and non-ionizing evaluation of bones. This paper presents a review of our research work of the last decade including experimental and computational studies for the ultrasonic assessment of fracture healing and osteoporosis. The axial transmission and the backscattering methods have been applied to investigate the variation of ultrasound velocity, the propagation of guided waves and the interaction of the complex scattering phenomena with bones. In the macrostructure level, computational models have been established mimicking healthy and pathologic bones, while the use of imaging modalities has opened new perspectives for the evaluation of the bone microstructure using QUS. In the nanostructure level, a deterministic hybrid model for bone healing and angiogenesis predictions under the presence of QUS has been established incorporating the spatiotemporal development of soft tissues, bone and the evolution of blood vessel network. The results reveal the promising monitoring potential of QUS and its positive impact on the acceleration of the bone healing process.

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Section: Discussionmentioning

confidence: 99%

Section: Ossification Process and Angiogenesis Predictions In Bone Hementioning

confidence: 99%

“…9. Spatiotemporal evolution of fibrous tissue, cartilage and bone matrix density: (a) under the presence of ultrasound, (b) without the presence of ultrasound (Vavva et al 2015).…”

Section: Ossification Process and Angiogenesis Predictions In Bone Hementioning

confidence: 99%

Section: Ossification Process and Angiogenesis Predictions In Bone Hementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Ultrasonic evaluation of intact, healing and osteoporotic long bones

Potsika¹,

Protopappas²,

Grivas³

et al. 2016

J Serb Soc Comp Mech

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The Application of Pulsed Electromagnetic Fields (PEMFs) for Bone Fracture Repair: Past and Perspective Findings

Daish¹,

Blanchard²,

Fox³

et al. 2018

Ann Biomed Eng

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Bone fractures are one of the most commonly occurring injuries of the musculoskeletal system. A highly complex physiological process, fracture healing has been studied extensively. Data from in vivo, in vitro and clinical studies, have shown pulsed electromagnetic fields (PEMFs) to be highly influential in the fracture repair process. Whilst the underlying mechanisms acting to either inhibit or advance the physiological processes are yet to be defined conclusively, several non-invasive point of use devices have been developed for the clinical treatment of fractures. With the complexity of the repair process, involving many components acting at different time steps, it has been a challenge to determine which PEMF exposure parameters (i.e., frequency of field, intensity of field and dose) will produce the most optimal repair. In addition, the development of an evidence-backed device comes with challenges of its own, with many elements (including process of exposure, construct materials and tissue densities) being highly influential to the field exposed. The objective of this review is to provide a broad recount of the applications of PEMFs in bone fracture repair and to then demonstrate what is further required for enhanced therapeutic outcomes.

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Computational modeling of long bones during the fracture healing process

Potsika¹,

Ποτσίκα²

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Η παρούσα διδακτορική διατριβή ασχολείται με την αριθμητική μοντελοποίηση των κατεαγότων καιοστεοπορωτικών μακρών οστών με βάση εικόνες ακουστικής μικροσκοπίας σάρωσης και τηδυνατότητα του υπερήχου να χρησιμοποιηθεί για τη διάγνωση και την παρακολούθηση τωνπαθολογιών των οστών. Ο βασικός στόχος είναι η διερεύνηση των πολύπλοκων φαινομένωνκυματικής σκέδασης που προκαλούνται από τη σύνθετη φύση του οστικού ιστού και του πώρου. Σεαυτή την κατεύθυνση, εφαρμόζονται θεωρητικές και αριθμητικές μεθοδολογίες για τον εντοπισμόμεταβολών στο πλάτος σκέδασης, την διάδοση των κυματοδηγούμενων ρυθμών και την ταχύτητα τουπρώτου αφιχθέντος σήματος σε διαδοχικά στάδια επούλωσης, καθώς και σε αριθμητικά μοντέλα τουφλοιώδους οστού με διαφορετικά ποσοστά πορώδους. Η αριθμητική προσομοίωση της διάδοσηςυπερήχου σε υγιή, κατεαγότα και οστεοπορωτικά οστά πραγματοποιήθηκε αρχικά με την ευρέωςχρησιμοποιούμενη τεχνική αξονικής μετάδοσης, ενώ η μέθοδος οπισθοσκέδασης αξιολογήθηκε επίσηςως σχετικά νέα μέθοδος. Έμφαση δίνεται στη διερεύνηση της πορώδους φύσης του πώρου και τουφλοιώδους οστού, η οποία ενσωματώθηκε στα αριθμητικά μοντέλα με τη χρήση των δεδομένωνακουστικής μικροσκοπίας σάρωσης, και σε μεταβολές που συμβαίνουν λόγω των παθολογιών τωνοστών.

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A mathematical model for bone healing predictions under the ultrasound effect

Cited by 3 publications

References 12 publications

Ultrasonic evaluation of intact, healing and osteoporotic long bones

Ultrasonic evaluation of intact, healing and osteoporotic long bones

The Application of Pulsed Electromagnetic Fields (PEMFs) for Bone Fracture Repair: Past and Perspective Findings

Computational modeling of long bones during the fracture healing process

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