A mathematical model describing the thermal virus inactivation

Advanced Kinetic Analysis as a Tool for Formulation Development and Prediction of Vaccine Stability

“…This experimental procedure is followed by the calculation of the unknown rate constant at required temperature by extrapolation using an Arrhenius dependence of the reaction rate on the temperature . However, stability predictions based on application of zero‐ or first‐order kinetics are very often too simplified for description of the degradation of biological products, which frequently undergo complex and multistep degradation reactions . As such, more sophisticated degradation kinetic models using Vogel–Fulcher–Tammann equation or Prout–Thompkins nucleation models may be useful to describe degradation in biological products .…”

“…19,20 However, stability predictions based on application of zero-or first-order kinetics are very often too simplified for description of the degradation of biological products, which frequently undergo complex and multistep degradation reactions. 21 As such, more sophisticated degradation kinetic models using Vogel-Fulcher-Tammann equation or Prout-Thompkins nucleation models may be useful to describe degradation in biological products. [22][23][24][25] Such more complicated approach in which a twostep kinetic model, including an n-th order and an autocatalytic component, was initially used to described the epoxy cure reaction 26 and was adapted more recently for protein aggregation kinetics.…”