A mathematical analysis of kinetic characteristics of oxidative phosphorylation in the animal brain under hypoxic conditions

Approaches to Prediction of the Adaptive State of the Brain Energetic System under Conditions of Hypoxia

“…The method of approximation of empirical dependence was previously tested by us for other parameters of energy metabolism in the brain: for analysis and prognosis of ¿ nal concentration of ATP from activity of mitochondrial enzyme complexes [14]; for evaluation of kinetic characteristics of oxidative phosphorylation in the brain of experimental animals [13]; for prediction of the limits of organism's resistance to hypoxia [8], etc. The use of the method of approximation of empirical dependencies in this study makes it possible to predict mCK activity by calculation methods and to determine ATP content in the brain under extreme conditions.…”