A mass transfer model of temporal drug deposition in artery walls

Abraham, John; Gorman, John M; Sparrow, E. M.; Stark, John R.; Kohler, Robert Ε.

doi:10.1016/j.ijheatmasstransfer.2012.11.053

Cited by 32 publications

(18 citation statements)

References 50 publications

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“…A number of models have appeared in the literature [9][10][11][12][13][14][15][16]. The individual models take account of different physical processes.…”

Section: Impact Of Balloon Permeability On Drug Deliverymentioning

confidence: 99%

“…The individual models take account of different physical processes. The authors previous work [16] includes both advection and diffusion in the drug-carrier fluid mixture, diffusion of the drug in the arterial tissue, and binding of the drug to the tissue. It was found that the presence of an advecting flow significantly increased the deposition of medicine into the artery (by a factor of approximately 10).…”

Section: Impact Of Balloon Permeability On Drug Deliverymentioning

confidence: 99%

“…It was found that the presence of an advecting flow significantly increased the deposition of medicine into the artery (by a factor of approximately 10). The artery-wall calculations reported here were per-formed using the model of [16]. A key input for these calculations is the viscosity of the carrier fluid.…”

Section: Impact Of Balloon Permeability On Drug Deliverymentioning

confidence: 99%

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Controlling the rate of penetration of a therapeutic drug into the wall of an artery by means of a pressurized balloon

Stark¹,

Gorman²,

Sparrow³

et al. 2013

JBiSE

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The focus of this paper is to propose, model, and characterize a means of accelerating the rate of delivery of therapeutic drugs to human tissues. The investigated means is a pressurized, permeable-walled balloon filled with a homogeneous mixture of the drug and the carrier fluid. The fluid mixture, driven by pressure, traverses the thickness of the balloon wall through laser-drilled pores. The number and deployment of the pores can be controlled to a high degree of precision. As a consequence, the wall of the balloon can be regarded as a homogeneous porous medium, and the traversing fluid flow can be analyzed by means of porous media models. When the balloon is in intimate contact with the surface of a tissue bed, the therapeutic fluid flows in series as it passes through the balloon wall and penetrates the tissue. The flow rate can be controlled by proper selection of the balloon permeability, the viscosity of the flowing medium, and the pressure internal to the balloon. The delivered concentration of the drug was predicted by coupling the present balloon-focused theory with a previously developed tissue-bed model that includes both diffusion and advection processes. The tribologic interaction of the pressurized balloon with an artery wall was investigated experimentally to assess the possible formation of aneurysms.

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“…A number of models have appeared in the literature [9][10][11][12][13][14][15][16]. The individual models take account of different physical processes.…”

Section: Impact Of Balloon Permeability On Drug Deliverymentioning

confidence: 99%

Section: Impact Of Balloon Permeability On Drug Deliverymentioning

confidence: 99%

Section: Impact Of Balloon Permeability On Drug Deliverymentioning

confidence: 99%

See 1 more Smart Citation

Controlling the rate of penetration of a therapeutic drug into the wall of an artery by means of a pressurized balloon

Stark¹,

Gorman²,

Sparrow³

et al. 2013

JBiSE

View full text Add to dashboard Cite

show abstract

“…However, the issue of uptake/binding is more controversial. Some authors have assumed equilibrium models ((McGinty et al, 2011), (Horner et al, 2010), (Abraham et al, 2013)), while others have considered simple loss terms (Pontrelli and de Monte, 2010). More recently, a second order reaction model which allows for saturable reversible binding of sirolimus to specific receptors and general extracellular matrix (ECM) sites has been proposed (Tzafriri et al, 2012).…”

Section: One-dimensional Modelsmentioning

confidence: 99%

Simulating Drug-eluting Stents - Progress Made and the Way Forward

McGinty¹,

McCormick²,

McKee³

et al. 2013

Proceedings of the 3rd International Conference on Simulation and Modeling Methodologies, Technologies and Applications

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Abstract:Drug-eluting stents have significantly improved the treatment of coronary artery disease. Compared with their bare metal predecessors, they offer reduced rates of restenosis and thus represent the current gold standard in percutaneous coronary interventions. Drug-eluting stents have been around for over a decade, and while progress is continually being made, they are not suitable in all patients and lesion types. Furthermore there are still real concerns over incomplete healing and late stent thrombosis. In this paper, some modelling approaches are reviewed and the future of modelling and simulation in this field is discussed.

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“…Although mass transport in tissue culture involves multiple biochemical species, studies focused on other tissue types, such as skin, cartilage, oculartissues, and blood vessels have clearly established the importance of adequate oxygen (Abraham et al, 2013;Ai and Vafai, 2006;Chung and Vafai, ;Chung and Vafai, 2013;de Monte et al, 2013;Denny and Walsh, ;Ethier and Moore, 1997;Gill et al, 2011;Johnson et al, 2009;Kaazempur-Mofrad et al, 2005;Karner and Perktold, 2000;Khakpour and Vafai, 2008;Kumar et al, 2004;Liu et al, 2011;Prosi et al, 2005;Stangeby and Ethier, 2002;Tarbell et al, 1988;Wang et al, 2009) and glucose delivery. (Boubriak et al, 2006;Converti et al, 1996;Day et al, 2013;Gao and Xu, 2011;Koutny, 2011a;Koutny, 2011b;Martineau, 2012;Mokhbi Soukane et al, 2007).…”

Section: Chapter 5: Mass Transport Modelmentioning

confidence: 99%

Movement Effects on the Flow Physics and Nutrient Delivery in Engineered Valvular Tissues

Salinas¹

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A mass transfer model of temporal drug deposition in artery walls

Cited by 32 publications

References 50 publications

Controlling the rate of penetration of a therapeutic drug into the wall of an artery by means of a pressurized balloon

Controlling the rate of penetration of a therapeutic drug into the wall of an artery by means of a pressurized balloon

Simulating Drug-eluting Stents - Progress Made and the Way Forward

Movement Effects on the Flow Physics and Nutrient Delivery in Engineered Valvular Tissues

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