A mass spectrometric procedure for rapid identification of trace volatile metabolites

Parker, Donald J.; Ruliffson, W. S.

doi:10.1016/0003-2697(67)90231-x

Cited by 5 publications

(3 citation statements)

References 4 publications

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“…These approaches allow the estimation of very low levels of acetylcholine and related compounds, but the problem of identification other than by parallel bioassay techniques and the various chromatographic comparisons remains. Under favorable circumstances, mass spectrometric methods can provide an absolute identification of trace amounts of suitable substances (4,5) and their application to the estimation and characterization of choline derivatives forms the basis of this paper. EXPERIMENTAL Materials.…”

Section: Discussionmentioning

confidence: 99%

Automatic apparatus for sampling and preparing gases for mass spectral analysis in studies of carbon isotope fractionation during methane metabolism

Silverman¹,

Oyama²

1968

Anal. Chem.

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may require from 50 to 150 seconds for processing. A spectrum containing 200 lines will usually require about 3 to 7 minutes for processing.The program HIRES2 usually requires 10 to 60 seconds for identifying the standard masses and computing the masses of all the lines.The computing time required by HIRES3 depends on the number of atoms to be considered and on the size of the constants which define the maximum number of each atom permitted in a given formula. About 40 to 60 seconds is typical for computing all possible combinations of C, C13, , O, and N for a spectrum containing 200 lines when one C13 and 2 to 4 O and N atoms are permitted in each ion. ACKNOWLEDGMENTThe authors acknowledge the valuable advice of A. C. Jones and J. H. Schachtschneider in some of the mathematical aspects of these programs.

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Section: Discussionmentioning

confidence: 99%

Automatic apparatus for sampling and preparing gases for mass spectral analysis in studies of carbon isotope fractionation during methane metabolism

Silverman¹,

Oyama²

1968

Anal. Chem.

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“…Identification and assay of submicrogram quantities of particular compounds, such as drugs, in biological samples (50)(51)(52)(53)(54) are obvious applications of these advantages. Identification and assay of submicrogram quantities of particular compounds, such as drugs, in biological samples (50)(51)(52)(53)(54) are obvious applications of these advantages.…”

Section: Applicability To Biochemical Studiesmentioning

confidence: 99%

Biochemical Aspects of High-Resolution Mass Spectrometry

Ge¹,

Fw²

1969

Annu. Rev. Biochem.

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“…Pesticide residues have been examined by mass spectrometry (835). A procedure for in vivo recording of partial pressures of gases in blood has been used (1577), and minute amounts of volatile components in tissue respiration have been detected and identified (1186).…”

Section: Analytical Determinationsmentioning

confidence: 99%