A Masquerade of Infectious Myositis as Polymyositis

Mank, Victoria; Brown, Kevin F.; Roberts, Jefferson

doi:10.4269/ajtmh.20-0168

Cited by 5 publications

(7 citation statements)

References 2 publications

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“…The total leukocyte count > 11000 cells/cmm is known as leukocytosis. Leukocytosis is a nonspecific marker of inflammation resulting from acute or chronic infection, malignancy, trauma, allergies, etc (14). In our study, the total leukocyte count showed a statistically significant increase across the groups, though the total leukocyte count was within the normal limits.…”

Section: Discussioncontrasting

confidence: 41%

Relationship between serum high-sensitivity C-reactive protein (hs-CRP) and glycated hemoglobin (HbA1c) in South Indian population

Vinod¹,

Ganesh²,

A.³

et al. 2023

Biomedicine

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Introduction and Aim: Cardiovascular disease are a leading cause of death in the world. Atherosclerosis plays the most important role in its pathophysiology. It is a slowly progressing chronic inflammatory process resulting in increased levels of inflammatory markers in serum. hs-CRP is a novel biomarker of coronary heart disease risk prediction. Type 2 diabetes mellitus individuals are at an increased risk of developing cardiovascular diseases. In this study, we aim to find the association of HbA1c with hs-CRP in the South Indian population. Materials and Methods: This was a retrospective study. The study participants were categorised into 3 groups based on their serum hs-CRP levels: Group 1 with hs-CRP < 1.0 mg/L; group 2 with hs-CRP 1.0 – 3.0 mg/L and group 3 with hs-CRP > 3.0 mg/L. The sample size was estimated to be 40 for each group. Age, fasting blood glucose, postprandial blood glucose, HbA1c, hs-CRP, total count, and ESR were collected. Statistical analyses were performed with SPSS version 16.0. Results: Age showed no significant difference among the groups. FBS, PPBS, HbA1c, TLC, and ESR showed a significant difference among the 3 groups. TLC, FBS, PPBS, and HbA1c had a significant positive correlation with hs-CRP. Conclusion: hs-CRP has a statistically significant positive correlation with HbA1c, fasting blood sugar, and postprandial blood sugar Additionally, we also observed that total leukocyte count had a significant positive correlation with hs-CRP and HbA1c. Hence, our results show that impaired glycemic control is associated with an increased risk of developing cardiovascular diseases.

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Section: Discussioncontrasting

confidence: 41%

Relationship between serum high-sensitivity C-reactive protein (hs-CRP) and glycated hemoglobin (HbA1c) in South Indian population

Vinod¹,

Ganesh²,

A.³

et al. 2023

Biomedicine

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“…Increased lymphocytes signify strong immune responses, be it from infections, inflammatory diseases, or vaccination. 51,52 IL-6, a serum or plasma cytokine, is released by immune cells upon inflammatory stimulus. IL-6 also travels to the liver to…”

Section: Discussionmentioning

confidence: 99%

Inflammatory and vascular biomarkers in post‐COVID‐19 syndrome: A systematic review and meta‐analysis of over 20 biomarkers

Yong

Halim

et al. 2023

Reviews in Medical Virology

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Severe acute respiratory syndrome coronavirus 2 may inflict a post-viral condition known as post-COVID-19 syndrome (PCS) or long-COVID. Studies measuring levels of inflammatory and vascular biomarkers in blood, serum, or plasma of COVID-19 survivors with PCS versus non-PCS controls have produced mixed findings. Our review sought to meta-analyse those studies. A systematic literature search was performed across five databases until 25 June 2022, with an updated search on 1 November 2022. Data analyses were performed with Review Manager and R Studio statistical software. Twenty-four biomarkers from 23 studies were meta-analysed. Higher levels of C-reactive protein (Standardized mean difference (SMD) = 0.20; 95%

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“…In our study, the animals receiving a high dose of S. epidermidis displayed leukocytosis at day 21, which persisted until day 42. Infection, stress and trauma are the most common causes of leukocytosis (32). In fact, leukocytosis is a good indicator of an infectious process (33) and most patients at an emergency room with a suspicion of an infection have leukocytosis (34).…”

Section: Discussionmentioning

confidence: 99%

Staphylococcus epidermidis’ Overload During Suckling Impacts the Immune Development in Rats

et al. 2022

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Mastitis is an inflammation of the mammary gland occurring in 3–33% of the breastfeeding mothers. The majority of mastitis cases have an infectious etiology. More than 75% of infectious mastitis are caused by Staphylococcus epidermidis and Staphylococcus aureus and involves breast milk microbiota alteration, which, may have an impact in lactating infant. The aim of this study was to analyze in rats during the suckling period and later in life the impact of a high and a low overload of Staphylococcus epidermidis, similarly as it occurs during the clinical and the subclinical mastitis, respectively. From days 2 to 21 of life, suckling rats were daily supplemented with low (Ls group) or high (Hs group) dose of S. epidermidis. Body weight and fecal humidity were periodically recorded. On days 21 and 42 of life, morphometry, hematological variables, intestinal gene expression, immunoglobulin (Ig) and cytokine profile and spleen cells’ phenotype were measured. Although no differences were found in body weight, Ls and Hs groups showed higher body length and lower fecal humidity. Both doses induced small changes in lymphocytes subpopulations, reduced the plasma levels of Ig and delayed the Th1/Th2 balance causing a bias toward the Th2 response. No changes were found in cytokine concentration. The low dose affected the Tc cells intestinal homing pattern whereas the high dose had an impact on the hematological variables causing leukocytosis and lymphocytosis and also influenced the intestinal barrier maturation. In conclusion, both interventions with Staphylococcus epidermidis overload during suckling, affects the immune system development in short and long term.

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A Masquerade of Infectious Myositis as Polymyositis

Cited by 5 publications

References 2 publications

Relationship between serum high-sensitivity C-reactive protein (hs-CRP) and glycated hemoglobin (HbA1c) in South Indian population

Relationship between serum high-sensitivity C-reactive protein (hs-CRP) and glycated hemoglobin (HbA1c) in South Indian population

Inflammatory and vascular biomarkers in post‐COVID‐19 syndrome: A systematic review and meta‐analysis of over 20 biomarkers

Staphylococcus epidermidis’ Overload During Suckling Impacts the Immune Development in Rats

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