A marriage made in MS

Qian, Mark G.; Lubman, David M.

doi:10.1021/ac00103a001

Cited by 16 publications

(10 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this paper, we describe an ion trap 12 interface for the ESI−ion mobility experiment that offers significant advantages in instrument performance. This interface is similar to one that has been recently developed for ESI−time-of-flight (TOF) MS experiments. − Here, we show that the ESI−ion trap interface is a simple means of concentrating ions during the drift tube measurements; this provides duty cycles that approach 100% and improvements in signal-to-noise (S/N) ratios (compared with existing methods) by factors of ∼10−30. The ion trap also provides ion pulses that are tightly focused both spatially and temporally, allowing ions to be efficiently injected into the ion mobility instrument.…”

mentioning

confidence: 67%

“…As mentioned above, the present work is closely related to recent advances in ESI−TOFMS measurements. − Lubman and co-workers have shown that the ESI−ion trap combination facilitates duty cycles near 100% for TOFMS, significantly improving S/N ratios, sensitivity, and mass resolution . The shortcomings of this approach arise from different pressure requirements for the ion trap (10 -4 −10 -3 Torr) and flight tube (<10 -7 Torr) regions of the instrument.…”

mentioning

confidence: 87%

See 1 more Smart Citation

An Ion Trap Interface for ESI−Ion Mobility Experiments

1997

View full text Add to dashboard Cite

A method for improving the sensitivity of ion mobility measurements of ions generated from continuous ionization sources such as electrospray ionization is described. The method involves an ion trap interface between the continuous source and the pulsed experiment. The trap allows the electrosprayed ion beam to be accumulated between pulses of the mobility experiment and provides tightly focused (both spatially and temporally) ion pulses for initiating experiments. Using this method, we have improved signal-to-noise ratios by factors of ∼10−30 compared with those of existing approaches and achieved experimental duty cycles of nearly 100%. With these improvements, it is possible to record complex ion mobility distributions in less than 10 s, and we have obtained detection limits of 1.3 pmol for the oligosaccharide maltotetraose. A detailed description of the experimental arrangement is given. An application of the improved methods in which collision-induced fragmentation of biomolecules is monitored by ion mobility spectrometry is described.

show abstract

mentioning

confidence: 67%

mentioning

confidence: 87%

An Ion Trap Interface for ESI−Ion Mobility Experiments

1997

View full text Add to dashboard Cite

show abstract

“…15 It can be operated with different ionization sources to create ions directly inside the trap or, alternatively, can be fed with ions generated from external atmospheric pressure sources. 16 An inherent disadvantage of the ion trap is its slow scanning speed for mass analysis, in comparison with timeof-flight mass spectrometers which are fast-pulsed devices. The combination of TOF instruments with quadrupole ion traps by Lubman and coworkers 14,[16][17][18] and Ding et al 19 was an important development in mass spectrometry instrumentation that resulted in widespread use of such devices.…”

Section: Introductionmentioning

confidence: 99%

“…16 An inherent disadvantage of the ion trap is its slow scanning speed for mass analysis, in comparison with timeof-flight mass spectrometers which are fast-pulsed devices. The combination of TOF instruments with quadrupole ion traps by Lubman and coworkers 14,[16][17][18] and Ding et al 19 was an important development in mass spectrometry instrumentation that resulted in widespread use of such devices. Iontrap/TOF devices are an excellent match 16 and have been successfully used in combination with different ionization methods such as ESI, 18,20,21 MALDI, 18,22,23 glow discharge, 24 photoionization, [25][26][27] and EI/CI.…”

Section: Introductionmentioning

confidence: 99%

“…The combination of TOF instruments with quadrupole ion traps by Lubman and coworkers 14,[16][17][18] and Ding et al 19 was an important development in mass spectrometry instrumentation that resulted in widespread use of such devices. Iontrap/TOF devices are an excellent match 16 and have been successfully used in combination with different ionization methods such as ESI, 18,20,21 MALDI, 18,22,23 glow discharge, 24 photoionization, [25][26][27] and EI/CI. [28][29][30] Also, studies of neutral volatile substances such as halocarbon compounds in air were performed using ion-trap/TOF devices.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Design and performance of an atmospheric pressure sampling interface for ion-trap/time-of-flight mass spectrometry

Setz

Schmitz

Zenobi

2006

Review of Scientific Instruments

View full text Add to dashboard Cite

An ion-trap/time-of-flight mass spectrometer in combination with an atmospheric pressure sampling interface was developed in order to simultaneously profit from the ease of sample handling at ambient pressure, from the storage and accumulation capabilities of an ion trap, and from the acquisition speed and sensitivity of a time-of-flight mass spectrometer. The sampling interface is an intermediate-pressure vacuum manifold that serves to enrich sampled analytes by jet separation with respect to the carrier gas ͑air͒ and simultaneously maintain vacuum conditions inside the ion-trap/ time-of-flight instrument. Neutral analyte molecules are sampled and later ionized either by electron impact or chemical ionization. Ion accumulation is performed with a rf-only quadrupole ion trap with ground potential on the end caps during storage. For mass analysis, the trap's electrodes serve as a pulsed ion source for the attached linear time-of-flight mass spectrometer. In addition, laser desorbed molecules can also be sampled with this kind of instrument. Successful operation is shown by analyzing volatile substances ͑aniline, bromobenzene, styrene, and perfluorotributylamine͒, as well as laser-desorbed organic solids. Figures of merit include a sensitivity of 10 ppm, resolving power of 300 and demonstration of a mass spectrum of laser-desorbed anthracene with a signal-to-noise ratio of 270.

show abstract

Development of an ion trap / linear time‐of‐flight mass spectrometer with electrospray ionization for micro‐column liquid chromatography detection

Purves

1995

J Microcolumn Separations

View full text Add to dashboard Cite

Abstract. A linear time-of-flight (TOF) mass spectrometer equipped with a quadrupole ion trap for ion storage was developed for mass analysis of ions generated by electrospray ionization (ESI). With this technique, the continuous ion beam from the ESI source is collimated by a set of focusing lenses into the ion trap where the ions are accumulated for a predetermined period of time. Extraction of the ions into the flight tube of the TOF mass spectrometer is achieved by applying a short duration voltage pulse to the exit endcap of the ion trap. The extraction frequency is variable, but is typically set at 10 Hz. It was shown that with a linear TOF mass spectrometer, mass resolution in the range of 600-950 can be routinely obtained. It was also demonstrated that a complete mass spectrum of bradykinin can be obtained with a direct injection of 75 fmol, or 0.5 pL of 150 nM of sample solution. Buffer gas pressure and the energy of the ions entering the ion trap, were found to be the key parameters in obtaining this sensitivity and resolution. In addition, the ESI ion trap/TOF system was developed and applied for microcolumn liquid chromatography detection of a simple protein mixture. o 1995 JohnWilcy & Sons, Inc.

show abstract

A marriage made in MS

Cited by 16 publications

References 17 publications

An Ion Trap Interface for ESI−Ion Mobility Experiments

An Ion Trap Interface for ESI−Ion Mobility Experiments

Design and performance of an atmospheric pressure sampling interface for ion-trap/time-of-flight mass spectrometry

Development of an ion trap / linear time‐of‐flight mass spectrometer with electrospray ionization for micro‐column liquid chromatography detection

Contact Info

Product

Resources

About