A marked shift in innate and adaptive immune response in chinese immigrants living in a western environment

Saiganesh, Aarti; Hales, Belinda J.; Li, Yuchun; Holt, Patrick G.; Souëf, Peter N. Le; Zhang, Guicheng

doi:10.1111/all.13531

Cited by 11 publications

(17 citation statements)

References 9 publications

(10 reference statements)

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“…Chinese immigrants who had resided in Australia for more than 5 years demonstrated attenuated innate cytokine responses following TLR stimulation [38], increased genome methylation, and decreased gene expression compared to newly arrived immigrants [39]. Furthermore, the intensity of innate cytokine responses to TLR ligands and correlations between innate and adaptive antibody responses to pathogen-associated antibodies were significantly weaker in the long-term Chinese immigrants compared to newly arrived immigrants [40]. This supports the hypothesis that prolonged reduced exposure to microbial loads and biodiversity present in Westernized environments over time may attenuate key immunoregulatory mechanisms involved in modulating susceptibility to allergic disease.…”

Section: First-generation International Immigrantsmentioning

confidence: 99%

Effects of Migration on Allergic Diseases

Tham

Zhu

2018

Int Arch Allergy Immunol

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Studies in migrant populations provide vital opportunities to investigate the role of environmental factors in the pathogenesis of allergic disorders. Differences in allergy prevalence have been observed between migrants and native-born subjects living in the same geographical location. Immigrants who migrate from less affluent countries with lower allergy prevalence tend to have a lower prevalence of allergic disorders compared to native-born residents of the more affluent host country. The patterns of allergic disease prevalence also differ between first- and second-generation migrants. The timing of migration in relation to birth, age at migration, and duration of residence in the host country also influence one’s atopic risk. A complex interplay of multiple environmental, socioeconomic, and cultural factors is likely responsible for these observed differences. Further research into the roles of various risk factors in modulating differences in allergic disease prevalence between migrant and native populations will enhance our understanding of the complex gene-environment interactions involved in the pathogenesis of allergic disorders.

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Section: First-generation International Immigrantsmentioning

confidence: 99%

Effects of Migration on Allergic Diseases

Tham

Zhu

2018

Int Arch Allergy Immunol

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“…We initiated a study on asthma and allergy in Chinese immigrants in Australia in 2012 [8]. This current study is part of a large Chinese immigrant study and the recruiting method has been described elsewhere [14]. Twenty-two newly-arrived Chinese immigrants (living in Australia < 6 months) and 22 long-term adult Chinese immigrants (living in Australia > 5 years) were recruited with age and gender matched over 3 month period (Nov 2014 to Feb 2015).…”

Section: Study Participants and Designmentioning

confidence: 99%

“…We have found a marked shift in the innate and adaptive immune response between Chinese immigrants living in Australia for less than 6 months and more than 5 years. This was achieved by comparing the whole blood toll-like receptors (TLRs) pathway cytokine response and sera immunoglobulin G (IgG)-associated responsiveness to specific microbial/virus pathogens [14,15]. Recently, our team reported that Chinese immigrant children living in Australia show different microbiome diversity and composition compared to Chinese-born Chinese children [16].…”

Section: Introductionmentioning

confidence: 99%

Linking the westernised oropharyngeal microbiome to the immune response in Chinese immigrants

Guo

Zhang

Saiganesh

et al. 2020

Allergy Asthma Clin Immunol

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Background: Human microbiota plays a fundamental role in modulating the immune response. Western environment and lifestyle are envisaged to alter the human microbiota with a new microbiome profile established in Chinese immigrants, which fails to prime the immune system. Here, we investigated how differences in composition of oropharyngeal microbiome may contribute to patterns of interaction between the microbiome and immune system in Chinese immigrants living in Australia. Methods: We recruited 44 adult Chinese immigrants: newly-arrived (n = 22, living in Australia < 6 months) and longterm Chinese immigrants (n = 22, living in Australia > 5 years), with age and gender matched. Oropharyngeal swabs, serum and whole blood were collected. The 16 s ribosomal RNA gene from the swabs was sequenced on the Illumina MiSeq platform. Innate immune responses were determined by 23 Toll-like receptors (TLR) pathway cytokines, while adaptive immune responses were determined by IgG-associated response to specific microbial/viral pathogens. Results: The relative abundance of the genus Leptotrichia was higher in long-term immigrants as compared to that in newly-arrived Chinese immigrants, while the genus Deinococcus was significantly lower in longterm Chinese immigrants. The genera uncultured Lachnospiraceae, Erysipelotrichaceae UCG-007, Veillonella, and Actinomycetales_ambiguous taxa were negatively correlated with cytokine IL-6 in long-term Chinese immigrants (rho range: − 0.46 ~ − 0.73). With respect to adaptive immunity, several microbial taxa were significantly associated with IgG1 responsiveness to microbial antigens in long-term immigrants, while a significant correlation with IgG1 responsiveness to viral antigens was detected in newly-arrived immigrants. Conclusions: The composition of the oropharyngeal microbiome varies between newly-arrived and long-term Chinese immigrants. Specific microbial taxa are significantly associated with immunological parameters but with different association patterns between newly-arrived and long-term Chinese immigrants.

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“…Toll-like receptor signalling has inverted Ushaped response over time with the Western environment Jing Guo 1,2 , Yong Song 1,2 , Aarti Saiganesh 3 , Belinda Hales 3 , Anthony Bosco 3 , Peter Le Souëf 3,4 , Guicheng (Brad) Zhang (1,2). In the current study, we aimed to identify the dynamic changes of innate immunity in response to durations of exposure to Western environment relating to the increased risk of allergic development.…”

Section: Oc09mentioning

confidence: 99%