A Marine Anthraquinone SZ-685C Overrides Adriamycin-Resistance in Breast Cancer Cells through Suppressing Akt Signaling

Zhu, Xun; He, Zhenjian; Wu, Jueheng; Yuan, Jie; Wen, Weitao; Hu, Yiwen; Jiang, Yi; Lin, Cuiji; Zhang, Qianhui; Lin, Min; Zhang, Henan; Wan, Yang; Chen, Hong; Zhong, Lili; She, Zhigang; Chen, Shengping; Lin, Yongcheng; Li, Mengfeng

doi:10.3390/md10040694

Cited by 33 publications

(57 citation statements)

References 27 publications

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“…It has been demonstrated that estrogen receptor (ER)-negative, invasive MD-MB-435 cells are highly sensitive to SZ-685C treatment. In addition, SZ-685C also represented a promising approach to the treatment of adriamycin-resistant breast cancer (13).…”

Section: Discussionmentioning

confidence: 99%

SZ-685C exhibits potent anticancer activity in both radiosensitive and radioresistant NPC cells through the miR-205-PTEN-Akt pathway

Wang

Liu

et al. 2013

Oncology Reports

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Radioresistance is a major obstacle to the treatment of human nasopharyngeal carcinoma (NPC). Emerging evidence has demonstrated that miRNAs are involved in cancer therapy resistance. Our research group established the radioresistant NPC cell line CNE2R derived from the CNE2 cell line, and demonstrated that irradiation-induced miR-205 determined the resistance of NPC through directly targeting PTEN. However, specific inhibitors targeting miRNAs are largely undetermined. SZ-685C was expected to abrogate the radioresistance of CNE2 cells through the miR-205‑PTEN-Akt pathway. SZ-685C exhibited a similar cytotoxic effect on both cell lines, and we demonstrated that both intrinsic and extrinsic pathways were activated by SZ-685C in the cell lines. Importantly, the miR-205-PTEN-Akt pathway was the key cell signaling pathway activated in the CNE2R cells upon SZ-685C treatment; however, the Stat3-Jab1-p27 pathway might participate in the pro-apoptotic effect in CNE2 cells but not in CNE2R cells. SZ-685C is a promising anticancer agent for treatment of NPC, and it exhibited pro-apoptotic activity in both radiosensitive and radioresistant NPC cells. Although the mechanisms between the two cell lines were not identical, the pro-apoptotic effects were similar between the two cell lines.

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Section: Discussionmentioning

confidence: 99%

SZ-685C exhibits potent anticancer activity in both radiosensitive and radioresistant NPC cells through the miR-205-PTEN-Akt pathway

Wang

Liu

et al. 2013

Oncology Reports

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“…All the isolated compounds (1)(2)(3)(4)(5)(6)(7)(8)(9) were also evaluated for their and acetylcholinesterase (AChE) inhibitory activities. Compounds 3, 4, 6, 7 and 9 exhibited weak AChE inhibitory activity at the concentration of 100 mM.…”

Section: Resultsmentioning

confidence: 99%

“…For example, compound SZ-685C, a hydroanthraquinone isolated from marine fungus Halorosellinia sp., showed potent cytotoxic activities. [4][5][6] Aspergilols H and I, hydroxyanthraquinones isolated from marine sedimentderived fungus Aspergillus versicolor, exhibited evident antiviral activity towards HSV-1. 7 And 8-hydroxyconiothyrinone B, isolated from alga-derived fungus Talaromyces islandicus, displayed strong antioxidant activity.…”

Section: Introductionmentioning

confidence: 99%

Harzianumnones A and B: two hydroxyanthraquinones from the coral-derived fungusTrichoderma harzianum

Shi

Hou

et al. 2018

RSC Adv.

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“…The diverse activities of anthraquinones isolated from marine-derived fungi with cytotoxic (Chen et al 2013a;Xie et al 2010;Zhu et al 2012), antiviral , antioxidant ) and other activities have attracted many interests for drug discovery. For example, SZ-685C, a hydroanthraquinone isolated from the marine-derived Halorosellinia fungus, exhibited potent cytotoxic activity (Chen et al 2013a;Xie et al 2010;Zhu et al 2012). In our investigation of bioactive anthraquinone derivatives from marinederived fungi Zheng et al 2012), a total of 54 anthraquinone monomers and dimers have been isolated from Nigrospora sp., Alternaria sp.…”

Section: Anthraquinonesmentioning

confidence: 99%

Metabolites from marine invertebrates and their symbiotic microorganisms: molecular diversity discovery, mining, and application

Liu

Zheng

Shao

et al. 2019

Mar Life Sci Technol

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Metabolites from marine organisms have proven to be a rich source for the discovery of multiple potent bioactive molecules with diverse structures. In recent years, we initiated a program to investigate the diversity of the secondary metabolites from marine invertebrates and their symbiotic microorganisms collected from the South China Sea. In this review, representative cases are summarized focusing on molecular diversity, mining, and application of natural products from these marine organisms. To provide a comprehensive introduction to the field of marine natural products, we highlight typical molecules including their structures, chemical synthesis, bioactivities and mechanisms, structure-activity relationships as well as biogenesis. The mining of marine-derived microorganisms to produce novel secondary metabolites is also discussed through the OSMAC strategy and via partial chemical epigenetic modification. A broad prospectus has revealed a plethora of bioactive natural products with novel structures from marine organisms, especially from soft corals, gorgonians, sponges, and their symbiotic fungi and bacteria.

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A Marine Anthraquinone SZ-685C Overrides Adriamycin-Resistance in Breast Cancer Cells through Suppressing Akt Signaling

Cited by 33 publications

References 27 publications

SZ-685C exhibits potent anticancer activity in both radiosensitive and radioresistant NPC cells through the miR-205-PTEN-Akt pathway

SZ-685C exhibits potent anticancer activity in both radiosensitive and radioresistant NPC cells through the miR-205-PTEN-Akt pathway

Harzianumnones A and B: two hydroxyanthraquinones from the coral-derived fungusTrichoderma harzianum

Metabolites from marine invertebrates and their symbiotic microorganisms: molecular diversity discovery, mining, and application

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