A marchi study of the distribution of the anterior commissure in the cat

Fox, Clement A.; Schmitz, John T.

doi:10.1002/cne.900790206

Cited by 80 publications

(6 citation statements)

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“…They could belong to DCX-expressing neurons of either OB or the piriform cortex, or both, as both structures send contralateral projections to homologic structures on the other side of the brain [Fox and Schmitz, 1943;Fox et al, 1948], showing that newly generated neurons are able to send long-range projections into the adult brain.…”

Section: Migration Of New Neurons Into the Piriform Cortexmentioning

confidence: 99%

Adult Neurogenesis in the Hedgehog (Erinaceus concolor) and Mole (Talpa europaea)

et al. 2010

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We investigated adult neurogenesis in two species of mammals belonging to the superorder Laurasiatheria, the southern white-breasted hedgehog (order Erinaceomorpha, species Erinaceus concolor) from Armenia and the European mole (order Soricomorpha, species Talpa europaea) from Poland. Neurogenesis in the brain of these species was examined immunohistochemically, using the endogenous markers doublecortin (DCX) and Ki-67, which are highly conserved among species. We found that in both the hedgehog and mole, like in the majority of earlier investigated mammals, neurogenesis continues in the subventricular zone (SVZ) of the lateral ventricles and in the dentate gyrus (DG). In the DG of both species, DCX-expressing cells and Ki-67-labeled cells were present in the subgranular and granular layers. In the mole, a strong bundle of DCX-labeled processes, presumably axons of granule cells, was observed in the center of the hilus. Proliferating cells (expressing Ki-67) were identified in the SVZ of lateral ventricles of both species, but neuronal precursor cells (expressing DCX) were also observed in the olfactory bulb (OB). In both species, the vast majority of cells expressing DCX in the OB were granule cells with radially orientated dendrites, although some periglomerular cells surrounding the glomeruli were also labeled. In addition, this paper is the first to show DCX-labeled fibers in the anterior commissure of the hedgehog and mole. These fibers must be axons of new neurons making interhemispheric connections between the two OB or piriform (olfactory) cortices. DCX-expressing neurons were observed in the striatum and piriform cortex of both hedgehog and mole. We postulate that in both species a fraction of cells newly generated in the SVZ migrates along the rostral migratory stream to the piriform cortex. This pattern of migration resembles that of the ‘second-wave neurons’ generated during embryonal development of the neocortex rather than the pattern observed during development of the allocortex. In spite of the presence of glial cells alongside DCX-expressing cells, we never found colocalization of DCX protein with a glial marker (vimentin or glial fibrillary acidic protein).

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Section: Migration Of New Neurons Into the Piriform Cortexmentioning

confidence: 99%

Adult Neurogenesis in the Hedgehog (Erinaceus concolor) and Mole (Talpa europaea)

et al. 2010

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“…The ol factory bulb has been known anatomically to receive many centrifugal fibers from the cerebrum (18)(19)(20)(21)(22), and there are many physiological evidences indicating that the ol factory bulb activity is regulated from the basal rhinencephalic as well as many other subcortical structures through this centrifugal fiber system (9, 12,15,[23][24][25][26][27]. However, Ottoson (6) has observed that the antidromic stimulation of the secondary olfactory pathways blocked the induced waves but left the slow potential of the olfactory bulb unaffected.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological Studies on the Electrical Activities of the Olfactory Bulb

Ueki¹,

Tanaka²,

Sugano³

1964

Japanese Journal of Pharmacology

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During the experiments observing the drug effects on the steady potential of various brain structures, the authors (1) found that the steady potentials of certain subcortical structures such as the hypothalamus and hippocampus were more sensitively altered by psychopharmacological agents than the EEG activity in the same areas. Although many attempts (2-4) have been made to explain the steady potential, its physiological signi ficance has been still unknown. The authors have been interested in this electrical phenomenon from their belief that changes in the steady potential would indicate the CNS activity in some different way from EEG changes . In order to elucidate the cor relation between a steady potential and EEG in the various states of activity of the brain, the more primitive brain structure seemed desirable to persue . The authors thus selected the olfactory bulb, because this structure showed a distinct afferent activity in response to olfactory stimulation and its excitatory as well as inhibitory states could be easily demonstrated. Ottoson (5, 6) has observed a slow potential elicited by odori ferous stimulation in the olfactory epithelium as well as in the olfactory bulb . Ottoson's slow potential is regarded as a DC potential change in this structure . The present study was conducted to ascertain the effects of drugs on the DC potential , slow potential and EEG activity of the olfactory bulb, in the hope of elucidating if any mutual cor relations of these electrical phenomena exist. METHODSForty-three cats of either sexes weighing from 2 to 4 kg were used in this experi ments. As soon as possible after decamethonium bromide 0 .5 mg/kg was injected intra venously in unanesthetized animals , artificial respiration was started through tracheal cannulation. The animal was then placed on an stereotaxic instrument , the skull was exposed with a large skin incision under local anesthesia . Pain in the margins of the operative wounds and pressure points from the stereotaxic instrument was carefully controlled by topical application of 2% lidocaine, containing epinephrine in an ap propriate concentration, throughout the experiment. The frontal sinus was opened and the dorsal surface of the olfactory bulb was exposed . A fine silver-silver chloride wire

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“…Interestingly, one problem as to the AN giving rise to the commissural fibers in the olfactory projections, has been widely studied in the rodent [Brodal, 1948;Valverde, 1964;Ferrer, 1967;Davis et al, 1978;De Olmoset al, 1978] and the rabbit [Young, 1942;Le Gros Clark and Meyer, 1947;Lohman and Mentink, 1969;Broadwell, 1975b], but has seldom been treated in the cat [Fox and Schmitz, 1943;Mascitti and Ortega, 1966]. In particular, a moot point on classifying the AN structure as related to the olfactory projections was discussed and briefed in detail by Lohman andMentink [1969] andBroadwell[ 1975b] in the rabbit.…”

Section: Discussionmentioning

confidence: 99%

“…These data concerning the olfactory projection systems are very useful and valuable in order to under stand the olfactory structure in the rhinencephalon. Although several remarkable investigations based on anatomical and physiological findings have previously demonstrated a similar pattern of the olfactory projec tions in the rodent [Brodal, 1948;Valverde, 1964;Powell et al, 1965;Ferrer, 1967;Heimer, 1968] and the rabbit [Young, 1942;Le Gros Clark and Meyer, 1947;Lohman and Mentink, 1969;Daval and Leveleau, 1974;Scalia and Winans, 1975], research on the direct fiber connections in the cat [Fox and Schmitz, 1943;Fox et al, 1944;Mascitti and Ortega, 1966;Dennis and Kerr, 1976] has not yet been fully com pleted at the present time. In order to contribute new anatomical data on the olfactory projections in the cat, the direct olfactory fiber projection systems were rein vestigated.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the interbulbar connections in the cat using the Fink-Heimer and HRP methods

Ryu¹,

Santonishi²

1980

Cells Tissues Organs

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The anterograde degeneration technique, using the Fink-Heimer method, and retrograde cell tracing with horseradish peroxidase (HRP) were used to analyze the afferent and efferent fiber projections of the olfactory bulb complex, consisting of the main olfactory bulb (MOB), the anterior olfactory nucleus (AN) and the accessory olfactory bulb (AOB) in the cat. The results reveal that the ipsilateral and contralateral fibers running via the anterior commissure to join the internal plexiform layer of both the ipsilateral and contralateral MOBs originate from the AN, whereas the ipsilateral fiber terminals running into the outer part of the plexiform layer of the pyriform cortex originate from the MOB and AOB. In consideration of the olfactory functional relays, it is suggested that the AN, both in the dorsolateral part and external layer, most likely stimulates some afferent and efferent impulses of the olfactory impact in the mammal.

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A marchi study of the distribution of the anterior commissure in the cat

Cited by 80 publications

References 9 publications

Adult Neurogenesis in the Hedgehog (Erinaceus concolor) and Mole (Talpa europaea)

Adult Neurogenesis in the Hedgehog (Erinaceus concolor) and Mole (Talpa europaea)

Pharmacological Studies on the Electrical Activities of the Olfactory Bulb

Assessment of the interbulbar connections in the cat using the Fink-Heimer and HRP methods

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