It is of great importance to endow personal protective equipments with bactericidal property combating against infected pathogens. Nanozyme that can generate reactive oxygen species (ROS) in an enzyme‐catalytic manner is regarded as a novel and promising nanobactericide. But until now, very rare of them is designed specifically for personal protective equipments. In this study, a multinanozyme of manganese oxide supported on Ce‐containing MOF (CeBTC) is constructed with post‐engineering via a quasi‐MOF strategy (denoted as MnOx/q‐CeBTC). The strategy enables a full exposure of the metal cluster nodes, introduction of new active Mn‐O‐Ce bonds and strengthened interaction between the metal nodes and the guest oxide. As an advanced multinanozyme, the MnOx/q‐CeBTC exhibits excellent multiple enzymatic activities at low temperature, and enables abundant and self‐cascade ROS generation without H2O2 addition. This empowers it with high efficiency in bacteria killing, which is also reflected when incorporated into face mask to combat against pathogen invasion even at low temperature. The results achieved in this work provide guidance for rational design of effective bactericide based on nanozyme and broad their application in personal protective equipment and other fields.This article is protected by copyright. All rights reserved