A malignant tumor of the vagina resembling synovial sarcoma.A light and electron microscopic study

Okagaki, Takashi; Ishida, Tsunehiro; Hilgers, Robert D.

doi:10.1002/1097-0142(197605)37:5<2306::aid-cncr2820370521>3.0.co;2-o

Cited by 38 publications

(4 citation statements)

References 45 publications

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“…It is an aggressive soft-tissue tumor arising from mesenchymal or epithelial cells. Although the clinical and pathologic features of vaginal synovial sarcoma have been well documented (44,45), our review of the literature revealed that the MR imaging features have not been documented, to our knowledge.…”

Section: Spindle Cell Synovial Sarcomamentioning

confidence: 78%

MR Imaging Features of Vaginal Malignancies

Parikh¹,

Barton²,

Ind³

et al. 2008

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Primary vaginal malignancies are rare, accounting for only 1%-2% of all gynecologic malignancies. Squamous cell carcinoma makes up about 85% of primary vaginal malignancies. This tumor characteristically arises from the posterior wall of the upper third of the vagina. The main patterns of disease are an ulcerating or fungating mass or an annular constricting lesion. At magnetic resonance (MR) imaging, squamous cell carcinoma has intermediate signal intensity on T2-weighted images and low signal intensity on T1-weighted images. The tumors that account for the remaining 15% of primary vaginal malignancies are adenocarcinoma, melanoma, and sarcomas. The signal intensity characteristics on MR images correlate with the histologic subtypes and reflect the MR imaging appearances of these histologic subtypes elsewhere in the body. Secondary malignancy of the vagina is far more frequent than primary vaginal malignancy. Most vaginal metastases occur by means of direct local spread from the cervix, uterus, or rectum. The MR imaging appearances of these metastases reflect the MR imaging appearances of the primary tumor.

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Section: Spindle Cell Synovial Sarcomamentioning

confidence: 78%

MR Imaging Features of Vaginal Malignancies

Parikh¹,

Barton²,

Ind³

et al. 2008

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“…Our case lacked any mitotic figures and had very well‐circumscribed margins. Benign mixed tumors can also be confused with the extremely rare malignant mixed tumor of the vagina which looks like synovial sarcoma ( 37,38 ) . The lack of tumor circumscription with the presence of cytologic atypia and mitotic activity are features in favor of malignancy.…”

Section: Discussionmentioning

confidence: 99%

Benign mixed tumor of the vagina: Case report with expanded immunohistochemical profile

Murdoch¹,

Al‐Nafussi

2003

Int J Gynecol Cancer

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We present a case of benign mixed tumor of the vagina with its typical clinicopathologic and expanded immunohistochemical features. The strong coexpression of the mesenchymal spindle cell component with epithelial markers such as CK7, together with strong CD10, Bcl2, and estrogen and progesterone receptors favors a mullerian derived tumor. The tumor is best labeled as benign mixed mullerian tumor as originally designated.

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“…Our case lacked any mitotic figures and had very well-circumscribed margins. Benign mixed tumors can also be confused with the extremely rare malignant mixed tumor of the vagina which looks like synovial sarcoma (37,38) . The lack of tumor circumscription with the presence of cytologic atypia and mitotic activity are features in favor of malignancy.…”

Section: Discussionmentioning

confidence: 99%