A Male Linkage Map of the Cattle (Bos taurus) Genome

Z., R.; Beever, Jonathan E.; Da, Yang; Green, C. A.; Ruß, Ingolf; Park, C.; Heyen, D. W.; Everts, Robin E.; Fisher, Simon; Overton, K. M.; Teale, A.J.; Kemp, Stephen J.; Hines, H. C.; Guérin, Gérard; Lewin, Harris A.

doi:10.1093/oxfordjournals.jhered.a022999

Cited by 111 publications

(77 citation statements)

References 24 publications

(26 reference statements)

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“…More than 98% of the markers that have been mapped by linkage analysis in sheep have been mapped on a common three-generation set of full-sibling sheep families, and it is the policy of the sheep gene mapping community to map all markers on the IMF. In contrast, a number of cattle linkage maps exist that have been developed with different sets of families and different sets of loci (Ma et al 1996;Barendse et al 1997;Kappes et al 1997). As a consequence, some difficulties are experienced in moving between the cattle maps to predict relative positions of loci, and several cattle mapping workshops have been held to address these issues (Taylor et al 1998;Casas et al 1999;Gu et al 2000).…”

Section: Discussionmentioning

confidence: 99%

An Enhanced Linkage Map of the Sheep Genome Comprising More Than 1000 Loci

Maddox¹

2001

Genome Research

210

136

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A medium-density linkage map of the ovine genome has been developed. Marker data for 550 new loci were generated and merged with the previous sheep linkage map. The new map comprises 1093 markers representing 1062 unique loci (941 anonymous loci, 121 genes) and spans 3500 cM (sex-averaged) for the autosomes and 132 cM (female) on the X chromosome. There is an average spacing of 3.4 cM between autosomal loci and 8.3 cM between highly polymorphic [polymorphic information content (PIC) Ն 0.7] autosomal loci. The largest gap between markers is 32.5 cM, and the number of gaps of >20 cM between loci, or regions where loci are missing from chromosome ends, has been reduced from 40 in the previous map to 6. Five hundred and seventy-three of the loci can be ordered on a framework map with odds of >1000 : 1. The sheep linkage map contains strong links to both the cattle and goat maps. Five hundred and seventy-two of the loci positioned on the sheep linkage map have also been mapped by linkage analysis in cattle, and 209 of the loci mapped on the sheep linkage map have also been placed on the goat linkage map. Inspection of ruminant linkage maps indicates that the genomic coverage by the current sheep linkage map is comparable to that of the available cattle maps. The sheep map provides a valuable resource to the international sheep, cattle, and goat gene mapping community.Sheep play an important role in modern agriculture and possess many heritable traits that are of economic importance. Additionally, the size, physiology, temperament, and lifespan of sheep make them an appropriate model for studying a variety of mammalian biological functions including lung physiology, immunology, endocrinology, reproduction, embryology, and fetal development. Sheep are also useful as disease models for inherited diseases, such as asthma (Wright et al.

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Section: Discussionmentioning

confidence: 99%

An Enhanced Linkage Map of the Sheep Genome Comprising More Than 1000 Loci

Maddox¹

2001

Genome Research

210

136

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“…For the genome scan, 147 microsatellite markers were selected using published bovine linkage maps (Barendse et al, 1994;Bishop et al, 1994;Ma et al, 1996;Barendse et al, 1997;Kappes et al, 1997). In addition, three candidate genes were included in the analysis.…”

Section: Genotyping and Map Constructionmentioning

confidence: 99%

Quantitative Trait Loci Affecting Milk Production Traits in Finnish Ayrshire Dairy Cattle

Viitala

Schulman

Koning

et al. 2003

Journal of Dairy Science

115

111

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A whole genome scan of Finnish Ayrshire was conducted to map quantitative trait loci (QTL) affecting milk production. The analysis included 12 half-sib families containing a total of 494 bulls in a granddaughter design. The families were genotyped with 150 markers to construct a 2764 cM (Haldane) male linkage map. In this study interval mapping with multiple-marker regression approach was extended to analyse multiple chromosomes simultaneously. The method uses identified QTL on other chromosomes as cofactors to increase mapping power. The existence of multiple QTL on the same linkage group was also analyzed by fitting a two-QTL model to the analysis. Empirical values for chromosome-wise significance thresholds were determined using a permutation test. Two genome-wise significant QTL were identified when chromosomes were analyzed individually, one affecting fat percentage on chromosome (BTA) 14 and another affecting fat yield on BTA12. The cofactor analysis revealed in total 31 genome-wise significant QTL. The result of two-QTL analysis suggests the existence of two QTL for fat percentage on BTA3. In general, most of the identified QTL confirm results from previous studies of Holstein-Friesian cattle. A new QTL for all yield components was identified on BTA12 in Finnish Ayrshire. (Key words: cofactor, dairy cattle, interval mapping, quantitative trait) Abbreviation key: BTA = Bos taurus chromosome, DYD = daughter yield deviations, FY = fat yield, F% = fat percentage, MY = milk yield, PIC = polymorphic information content, PY = protein yield, P% = protein percentage.

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“…The proportion of heterozygous individuals in the meiogynogenetic progeny (K) is a function of the distance between the locus and the centromere. A coefficient of the interference value (k) of 0.2 was used to convert K to the corrected map distances (22,23).…”

Section: Genotyping and Linkage Analysismentioning

confidence: 99%

Altered Self-Erythrocyte Recognition and Destruction in an Inbred Line of Tilapia (Oreochromis aureus)

Shirak

Bendersky

Hulata

et al. 2006

The Journal of Immunology

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Carboxyfluorescein diacetate (cFDA)-stained autologous and syngeneic tilapia (Oreochromis aureus) erythrocytes are recognized by effector peripheral blood leukocytes and lysed after a short culture period of 4 h. The hemolysis level was evaluated by measuring the fluorescence of the released cFDA. The degree of lysis of stained target erythrocytes of 60 individuals revealed a trimodal distribution statistically stratified into three groups of low (LR), intermediate (IR), and high (HR) responders. Depletion of the majority of phagocytes from leukocytes lowered the lysis level of HR to that of LR. A highly significant increase of LR cytotoxicity was obtained after the addition of conditioned medium from HR but only in the presence of phagocytes. Genetic analysis of offspring from four crosses (IR × HR, IR × LR, HR × LR, and LR × LR) revealed a quantitative trait locus (QTL) segregating for the level of response linked to markers UNH207 and UNH231 on linkage group 6 of tilapia. Based on segregation analysis of 58 gynogenetic BIU-1 offspring, the distances from the centromere were estimated as 21.5, 11.5, and 9.0 cM for UNH207, UNH231, and the QTL, respectively. It is suggested that 1) self-target recognition and destruction requires both cFDA-altered self-erythrocyte membrane and membrane structures normally present in autologous, syngeneic, and xenogeneic targets; 2) natural cytotoxic cells and/or macrophages are involved in erythrocyte lysis; and 3) the lysis level is codominantly inherited by a QTL segregating on tilapia linkage group 6.

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A Male Linkage Map of the Cattle (Bos taurus) Genome

Cited by 111 publications

References 24 publications

An Enhanced Linkage Map of the Sheep Genome Comprising More Than 1000 Loci

An Enhanced Linkage Map of the Sheep Genome Comprising More Than 1000 Loci

Quantitative Trait Loci Affecting Milk Production Traits in Finnish Ayrshire Dairy Cattle

Altered Self-Erythrocyte Recognition and Destruction in an Inbred Line of Tilapia (Oreochromis aureus)

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