A Maitake (<i>Grifola frondosa</i>) polysaccharide ameliorates Alzheimer's disease-like pathology and cognitive impairments by enhancing microglial amyloid-β clearance

Bai, Yao; Chen, Lingling; Yao, Chi; Chen, Xinmeng; Dong, Yilong; Zheng, Shangyong; Zhang, Lei; Li, Weiyuan; Du, Jing; Li, Hongliang

doi:10.1039/c9ra08245j

Cited by 32 publications

(27 citation statements)

References 29 publications

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“…A Maitake-derived polysaccharide called proteo-β-glucan (PGM), was reported to be a strong immunomodulator [26]. However, it remained uncertain if this polysaccharide could have immunomodulatory and neuroprotective effects on transgenic APP/PS1 mice, a common model for AD [26]. This study showed PGM-enhanced learning and memory, with reduced histopathological irregularities and neuronal loss in APP/PS1 mice [26].…”

Section: Antioxidant Activity Of Polysaccharidesmentioning

confidence: 84%

Section: Antioxidant Activity Of Polysaccharidesmentioning

confidence: 99%

“…According to Bai et al [26] the edible and curative mushroom, Maitake, is highly nutritious and contains a large amount of biologically active and health-promoting compounds [26]. A Maitake-derived polysaccharide called proteo-β-glucan (PGM), was reported to be a strong immunomodulator [26]. However, it remained uncertain if this polysaccharide could have immunomodulatory and neuroprotective effects on transgenic APP/PS1 mice, a common model for AD [26].…”

Section: Antioxidant Activity Of Polysaccharidesmentioning

confidence: 99%

“…Anti-PD activity was also recently determined for natural polysaccharides via increasing cellular autophagy [22]. Several other polysaccharides also have anti-AD effects [23][24][25][26][27]. Table 1 summarizes the potential protective and therapeutic activities of natural polysaccharides in neurodegeneration.…”

Section: Introductionmentioning

confidence: 99%

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Natural Polysaccharides as Preventive and Therapeutic Horizon for Neurodegenerative Diseases

et al. 2021

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Neurodegenerative diseases are a serious and widespread global public health burden amongst aging populations. The total estimated worldwide global cost of dementia was US$818 billion in 2015 and has been projected to rise to 2 trillion US$ by 2030. While advances have been made to understand different neurodegenerative disease mechanisms, effective therapeutic strategies do not generally exist. Several drugs have been proposed in the last two decades for the treatment of different types of neurodegenerative diseases, with little therapeutic benefit, and often with severe adverse and side effects. Thus, the search for novel drugs with higher efficacy and fewer drawbacks is an ongoing challenge in the treatment of neurodegenerative disease. Several natural compounds including polysaccharides have demonstrated neuroprotective and even therapeutic effects. Natural polysaccharides are widely distributed in plants, animals, algae, bacterial and fungal species, and have received considerable attention for their wide-ranging bioactivity, including their antioxidant, anti-neuroinflammatory, anticholinesterase and anti-amyloidogenic effects. In this review, we summarize different mechanisms involved in neurodegenerative diseases and the neuroprotective effects of natural polysaccharides, highlighting their potential role in the prevention and therapy of neurodegenerative disease.

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Section: Antioxidant Activity Of Polysaccharidesmentioning

confidence: 84%

Section: Antioxidant Activity Of Polysaccharidesmentioning

confidence: 99%

Section: Antioxidant Activity Of Polysaccharidesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Natural Polysaccharides as Preventive and Therapeutic Horizon for Neurodegenerative Diseases

et al. 2021

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“…Various kinds of polysaccharides reportedly have memory-improving activity against various animal models, such as those with amyloid b- and scopolamine-induced memory impairment [ 36 , 37 , 38 , 39 ]. It is generally believed that only some small molecules can cross the blood–brain barrier (BBB) via lipid mediation.…”

Section: Discussionmentioning

confidence: 99%

Sulfated Polysaccharide Isolated from the Nacre of Pearl Oyster Improves Scopolamine-Induced Memory Impairment

et al. 2021

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Pearl and nacre have been used in traditional medicines for treating brain dysfunctions, such as epilepsy, myopia, palpitations and convulsions. We previously showed that a pearl oyster nacre extract improves scopolamine-induced memory impairments using the Y-maze, Banes maze and object recognition tests. In this study, we aimed to isolate the memory-improving substance using ion-exchange column chromatography and reverse-phase column chromatography and elucidate the molecular mechanism underlying its memory-improving activity. The isolated substance was found to be a sulfated polysaccharide with a molecular weight of approximately 750 kDa. Monosaccharide composition analysis showed that it was rich in galactose, glucose, mannose and uronic acid. Furthermore, the mRNA expression levels of oxidative stress, inflammatory response and neuroprotective factors in the cerebral cortex were investigated. Treatment with the polysaccharide increased the expression levels of the antioxidant enzymes Cu, Zn -superoxide dismutase (SOD) and catalase and attenuated the scopolamine-mediated upregulation of the inflammatory cytokines interleukin-1 and interleukin-6. In addition, the polysaccharide suppressed the decrease in the expression levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF). These findings strongly suggest that the polysaccharide in the nacre extract mediated its antiamnesic effects by preventing oxidative stress and inflammation and increasing the expression levels of BDNF and NGF.

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Microbially Synthesized Food

Chaudhary,

Kumari,

Sharma

et al. 2024

Nonthermal Food Processing, Safety, and Preservation

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A Maitake (Grifola frondosa) polysaccharide ameliorates Alzheimer's disease-like pathology and cognitive impairments by enhancing microglial amyloid-β clearance

Abstract: PGM ameliorates AD-like pathology and cognitive impairments by enhancing microglial amyloid-β clearance.

Cited by 32 publications

References 29 publications

Natural Polysaccharides as Preventive and Therapeutic Horizon for Neurodegenerative Diseases

Natural Polysaccharides as Preventive and Therapeutic Horizon for Neurodegenerative Diseases

Sulfated Polysaccharide Isolated from the Nacre of Pearl Oyster Improves Scopolamine-Induced Memory Impairment

Microbially Synthesized Food

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