A Magnetoelastic Ricin Immunosensor

Ruan, Chuanmin; Varghese, K. Oomman; Grimes, Craig A.; Zeng, Ke; Yang, Xiping; Mukherjee, Niloy; Ong, Keat Ghee

doi:10.1166/sl.2004.041

Cited by 17 publications

(12 citation statements)

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“…The use of fluorescence-based fiber optics (Narang et al, 1997), colloidal gold particles (Shyu et al, 2002b), and electrochemiluminescence (Garber and O'Brien, 2008), has significantly improved assay times without sacrificing the sensitivity associated with the classical ELISAs. Variations in the solid phase surface of the immunoassay have been also investigated by using magnetic microspheres (Yu et al, 2000) and gold-coated magnetoelastic sensor surfaces (Ruan et al, 2004;Shankar et al, 2005). The use of microspheres generated an increase in collective surface area, providing improvements in sensitivity and assay time, while a magnetoelastic sensor surface also helped to reduce total assay time.…”

Section: Methods That Cannot Identify Biologically Active Ricinmentioning

confidence: 99%

Ricin detection: Tracking active toxin

Bozza

Tolleson

Rosado

et al. 2015

Biotechnology Advances

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Ricin is a plant toxin with high bioterrorism potential due to its natural abundance and potency in inducing cell death. Early detection of the active toxin is essential for developing appropriate countermeasures. Here we review concepts for designing ricin detection methods, including mechanism of action of the toxin, advantages and disadvantages of current detection assays, and perspectives on the future development of rapid and reliable methods for detecting ricin in environmental samples.

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Section: Methods That Cannot Identify Biologically Active Ricinmentioning

confidence: 99%

Ricin detection: Tracking active toxin

Bozza

Tolleson

Rosado

et al. 2015

Biotechnology Advances

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“…Magneto-elastic sensors can be used to detect chemicals such as carbon dioxide [16] or ammonia [17], biological cells [18], or to measure pH [19]. The principle is to detect the mass of chemical or biomass stuck on the surfaces.…”

Section: Chemical Sensormentioning

confidence: 99%

“…The difficulty is to functionalize the surface in such a way that the product to be detected sticks the surface and no other contaminating elements. Ruan et al describe the functionalization process to design a sensor for measuring ricin in solution [19]. The sample is first cut using a computer controlled laser cutter.…”

Section: Chemical Sensormentioning

confidence: 99%

Magneto-Elastic Resonance: Principles, Modeling and Applications

Bras¹,

Grenèche²

2017

Resonance

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The magnetostriction effects are first discussed in the frame of the magneto-elastic resonance to define important values mainly the magneto-elastic coupling factor, k 33 . We review the different magnetostrictive materials according to their developments, with a special attention to amorphous ribbons to design magnetostrictive resonators. Furthermore, we focus on the current instrumental setups including their limitations, and then on the usual measurement procedures of the resonators, particularly the frequency domain measurement. In addition, an innovative approach based on the magneto-elastic impedance is reported, together with an analytical model which establishes the complete transfer function between the input and output voltages. This model is applied to ribbon-shaped materials, particularly to determine the magneto-elastic coupling factor. These resonators are suitable to sensing applications, i.e., to estimate the influential quantities such as the temperature, magnetic fields and mass stuck on the resonating surface.

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“…Prior to measurement, the sensor was thoroughly washed with deionized water to remove any nonspecific adsorption of AP-conjugated anti-ricin antibodies. The fabrication process is detailed in [16].…”

Section: G Fabrication Of Ricin Sensormentioning

confidence: 99%

“…Magnetoelastic sensors have been used for detection of biological targets and protein biotoxins such as Escherichia coli (E. coli) O157:H7 [14], staphylococcal enterotoxin B [15], and ricin [16]. In addition, they have also been used to monitor blood coagulation behavior [17].…”

mentioning

confidence: 99%

Quantification of multiple bioagents with wireless, remote-query magnetoelastic microsensors

et al. 2006

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This paper presents a micromagnetoelastic sensor array for simultaneously monitoring multiple biological agents. Magnetoelastic sensors, made of low-cost amorphous ferromagnetic ribbons, are analogous and complementary to piezoelectric acoustic wave sensors, which track parameters of interest via changes in resonance behavior. Magnetoelastic sensors are excited with magnetic ac fields, and, in turn, they generate magnetic fluxes that can be detected with a sensing coil from a distance. As a result, these sensors are highly attractive, not only due to their small size and low cost, but also because of their passive and wireless nature. Magnetoelastic sensors have been applied for monitoring pressure, temperature, liquid density, and viscosity, fluid flow velocity and direction, and with chemical/biological responsive coatings that change mass or elasticity, various biological and chemical agents. In this paper, we report the fabrication and application of a six-sensor array for simultaneous measurement of Escherichia coli O157:H7, staphylococcal enterotoxin B, and ricin. In addition, the sensor array also monitors temperature and pH so the measurements are independent from these two parameters.

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A Magnetoelastic Ricin Immunosensor

Cited by 17 publications

References 0 publications

Ricin detection: Tracking active toxin

Ricin detection: Tracking active toxin

Magneto-Elastic Resonance: Principles, Modeling and Applications

Quantification of multiple bioagents with wireless, remote-query magnetoelastic microsensors

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