A magnetic vehicle realized tumor cell-targeted radiotherapy using low-dose radiation

Chen, Hsiao Ping; Tung, Fu I.; Chen, Ming Hong; Liu, Tse Ying

doi:10.1016/j.jconrel.2016.02.025

Cited by 31 publications

(17 citation statements)

References 37 publications

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“…[216,217] Sanche et al reported that Au nanoparticles showed the ability to dramatically enhance the radio-sensitization of cisplatin under X-ray radiation, by 3-fold increase in DNA double strand breaks when one cisplatin molecule was bound to one Au nanoparticle, and 7.5-fold increase when two cisplatin molecules bound to one Au nanoparticles. [216,217] Sanche et al reported that Au nanoparticles showed the ability to dramatically enhance the radio-sensitization of cisplatin under X-ray radiation, by 3-fold increase in DNA double strand breaks when one cisplatin molecule was bound to one Au nanoparticle, and 7.5-fold increase when two cisplatin molecules bound to one Au nanoparticles.…”

Section: Inorganic Nanoparticles For Chemo-radiotherapymentioning

confidence: 99%

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

et al. 2017

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Radiation therapy (RT) including external beam radiotherapy (EBRT) and internal radioisotope therapy (RIT) has been widely used for clinical cancer treatment. However, owing to the low radiation absorption of tumors, high doses of ionizing radiations are often needed during RT, leading to severe damages to normal tissues adjacent to tumors. Meanwhile, the RT efficacies are limited by different mechanisms, among which the tumor hypoxia-associated radiation resistance is a well-known one, as there exists hypoxia inside most solid tumors while oxygen is essential to enhance radiation-induced DNA damages. With the development in nanotechnology, there have been great interests in using nanomedicine strategies to enhance radiation responses of tumors. Nanomaterials containing high-Z elements to absorb radiation rays (e.g. X-ray) can act as radio-sensitizers to deposit radiation energy within tumors and promote treatment efficacy. Nanoscale carriers are able to deliver therapeutic radioisotopes into tumors for internal RIT, or chemotherapeutic drugs for synergistically combined chemo-radiotherapy. As uncovered in recent studies, the tumor microenvironment could be modulated by various nanomedicine approaches to overcome hypoxia-associated radiation resistance. Herein, the authors will summarize the applications of nanomedicine for RT cancer treatment, and pay particular attention to the latest development of 'advanced materials' for enhanced cancer RT.

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Section: Inorganic Nanoparticles For Chemo-radiotherapymentioning

confidence: 99%

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

et al. 2017

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“…Cerium was used to doped the TiO 2 anatase structures to increase photochemical reactions owing to its strong catalytic potential and light response extension [31]. Furthermore, it could suppress the recombination of electron-hole pairs and increase their lifetime.…”

Section: Types Of Photosensitizersmentioning

confidence: 99%

“…Each PS is activated by a defined light of wavelength and the Tumors deep inside the body are not usually treated with photodynamic therapy. A relatively new approach, XPDT [10,11,[23][24][25][26][27][28][29][30][31], is based on X-rays which can penetrate more deeply into tissue than PDT light wavelength. XPDT is much better than traditional PDT (excited by UV-Vis light) in terms of tissue penetration.…”

Section: Introductionmentioning

confidence: 99%

Nanocomposites for X-Ray Photodynamic Therapy

Gadzhimagomedova

Zolotukhin

Kit

et al. 2020

IJMS

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Photodynamic therapy (PDT) has long been known as an effective method for treating surface cancer tissues. Although this technique is widely used in modern medicine, some novel approaches for deep lying tumors have to be developed. Recently, deeper penetration of X-rays into tissues has been implemented, which is now known as X-ray photodynamic therapy (XPDT). The two methods differ in the photon energy used, thus requiring the use of different types of scintillating nanoparticles. These nanoparticles are known to convert the incident energy into the activation energy of a photosensitizer, which leads to the generation of reactive oxygen species. Since not all photosensitizers are found to be suitable for the currently used scintillating nanoparticles, it is necessary to find the most effective biocompatible combination of these two agents. The most successful combinations of nanoparticles for XPDT are presented. Nanomaterials such as metal–organic frameworks having properties of photosensitizers and scintillation nanoparticles are reported to have been used as XPDT agents. The role of metal–organic frameworks for applying XPDT as well as the mechanism underlying the generation of reactive oxygen species are discussed.

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“…The radiosensitizing effects of porphyrin compounds such as Photofrin and HpD have been reported (59)(60)(61). A recent study demonstrated the use of radiotherapy with tumour-specific folic acid-conjugated carboxymethyl lauryl chitosan/superparamagnetic iron oxide micelles to effectively deliver porphyrin compounds (chlorin e6) to cancer cells (62). Although 5-ALA is well-known as a specific reagent for photodynamic therapy and fluorescence-guided resection in neurosurgery (8,63), 5-ALA is not itself a porphyrin compound but a prodrug that is converted into PpIX within tumour cell mitochondria (7).…”

Section: -Ala Enhances Mitochondrial Stress By Ir and Leads To Increased Cell Death With Mitochondrial Changes In Glioma Cellsmentioning

confidence: 99%

5-Aminolevulinic acid enhances mitochondrial stress upon ionizing irradiation exposure and increases delayed production of reactive oxygen species and cell death in glioma cells

Ueta

Yamamoto

Tanaka

et al. 2016

International Journal of Molecular Medicine

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5-Aminolevulinic acid (5-ALA) can accumulate protoporphyrin IX (PpIX) in tumour cell mitochondria and is well known for its utility in fluorescence-guided resection of malignant gliomas as a live molecular marker. Previously, we and other authors demonstrated that 5-ALA has a radiosensitizing effect for tumours. In the present study, we aimed to investigate the mechanism underlying the radiosensitizing effect of 5-ALA by focusing on glioma cell mitochondria. Using an enhancer (ciprofloxacin) of 5-ALA-induced PpIX accumulation, we evaluated the influence of ionizing irradiation (IR) and delayed reactive oxygen species (ROS) production 12 h after IR by colony-forming assay and flow cytometry (FCM) with different amounts of PpIX accumulation. The mitochondrial mass and mitochondrial electron transport chain (mtETC) activity were evaluated by FCM and western blot analysis. Cell death and delayed ROS production after IR in glioma cells were increased in proportion to 5-ALA-induced PpIX accumulation. Delayed ROS production enhanced by 5-ALA localized to the glioma cell mitochondria. Mitochondrial mass and mitochondrial complex III activity, among mtETC factors, were also increased 12 h after IR in glioma cells in proportion to 5-ALA-induced PpIX accumulation with some variation. These results suggest that 5-ALA enhances IR-induced mitochondrial oxidative stress and leads to increased cell death with mitochondrial changes, thereby acting as a targeting mitochondrial drug, and so‑called radiosensitizer in glioma cells.

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A magnetic vehicle realized tumor cell-targeted radiotherapy using low-dose radiation

Cited by 31 publications

References 37 publications

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

Nanocomposites for X-Ray Photodynamic Therapy

5-Aminolevulinic acid enhances mitochondrial stress upon ionizing irradiation exposure and increases delayed production of reactive oxygen species and cell death in glioma cells

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