A magnetic relaxation switching immunosensor for one-step detection of salbutamol based on gold nanoparticle–streptavidin conjugate

Abstract

A magnetic relaxation switching immunosensor based on gold nanoparticles–streptavidin conjugate for the detection of salbutamol.

Microfluidic-Based Synthesis of Magnetic Nanoparticles Coupled with Miniaturized NMR for Online Relaxation Studies

“…7 Most applications require particles with high magnetization that interact with the molecular world. To achieve high contrast in magnetic resonance imaging (MRI) 8,9 or high sensitivity in immunoassays based on relaxivity switches 10 particles with high NMR relaxivity are necessary. 11 The dependency of particles concentration on the inverse relaxation time is referred to as NMR relaxivity.…”

Homogeneous Biosensing Based on Magnetic Particle Labels

“…On the other end of the scale bar, also very small molecules have been detected in various sample solutions. For example, hormone-like bisphenol A molecules have been tested in drinking water with a LoD of 400 pg/mL [ 208 ], enantiomeric impurities in solutions of the amino acid phenylalanine have been examined [ 209 ], and the salbutamol drug has been measured in swine urine samples [ 210 ]. Identification of inhibitors for toxins released by the Anthrax bacterium by measurements of the T 2 relaxation time has also been reported [ 211 ].…”

Magnetic relaxation switching assay based on three-dimensional assembly of Fe3O4@ZIF-8 for detection of cadmium ions

“…In contrast, the magnetic relaxation switching (MRS) biosensor can be utilized in turbid and lightimpermeable media without separation and purication steps. [15][16][17] It has been widely used to analyze different targets, including heavy metals, 18 DNA, 19 viruses, 20 bacteria, 21 pesticide residues, 22,23 hormones, 24 and antibiotics. 25,26 The principles of conventional MRS biosensors generally rely on dispersion/ aggregation or altered concentration of magnetic nanoparticles (MNPs).…”