A magnetic control enrichment technique combined with terahertz metamaterial biosensor for detecting SARS-CoV-2 spike protein

Bi, Hao; You, Rui; Bian, Xiaomeng; li, Peng; Zhao, Xiaoguang; You, Zheng

doi:10.1016/j.bios.2023.115763

Cited by 5 publications

(2 citation statements)

References 52 publications

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“…Bi et al 133 employed magnetic control in conjunction with the metasurface biosensor to improve performance in identifying the SARS-CoV-2 spike protein. They linked the antibody (Ab) to the surface of Au nanoparticles first and then to the magnetic nanoparticles (MNPs) (Ab-Au@Fe 3 O 4 ) to enable the magnetic controls.…”

Section: Metasurface-based Biosensorsmentioning

confidence: 99%

Advancements and Perspectives in Optical Biosensors

Mostufa,

Rezaei,

Ciannella

et al. 2024

ACS Omega

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Optical biosensors exhibit immense potential, offering extraordinary possibilities for biosensing due to their high sensitivity, reusability, and ultrafast sensing capabilities. This review provides a concise overview of optical biosensors, encompassing various platforms, operational mechanisms, and underlying physics, and it summarizes recent advancements in the field. Special attention is given to plasmonic biosensors and metasurface-based biosensors, emphasizing their significant performance in bioassays and, thus, their increasing attraction in biosensing research, positioning them as excellent candidates for lab-on-chip and point-of-care devices. For plasmonic biosensors, we emphasize surface plasmon resonance (SPR) and its subcategories, along with localized surface plasmon resonance (LSPR) devices and surface enhance Raman spectroscopy (SERS), highlighting their ability to perform diverse bioassays. Additionally, we discuss recently emerged metasurface-based biosensors. Toward the conclusion of this review, we address current challenges, opportunities, and prospects in optical biosensing. Considering the advancements and advantages presented by optical biosensors, it is foreseeable that they will become a robust and widespread platform for early disease diagnostics.

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Section: Metasurface-based Biosensorsmentioning

confidence: 99%

Advancements and Perspectives in Optical Biosensors

Mostufa,

Rezaei,

Ciannella

et al. 2024

ACS Omega

View full text Add to dashboard Cite

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“…There is no clear reason why SPhP-based sensors are less effective based on available understanding of phonon polaritons and available data. The gaps in our understanding likely arise because SEIRA ,,− is a resonant process; this relies on optimizing resonances so that when loaded with a molecule, the cavity becomes optimally coupled . As the mode lifetime in sensor structures made for SEIRA has largely been unexplored for SPhP modes, this is suggestive that enhancement must operate differently between plasmon and phonon-based sensors.…”

Section: Introductionmentioning

confidence: 99%

Lifetime and Molecular Coupling in Surface Phonon Polariton Resonators

Esfidani,

Tadjer,

Folland

2024

ACS Omega

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Surface phonon polariton (SPhP) modes in polar semiconductors offer a low-loss platform for infrared nanophotonics and sensing. However, the efficient design of polariton-enhanced sensors requires a quantitative understanding of how to engineer the frequency and lifetime of SPhPs in nanophotonic structures. Here, we study organ-pipe resonances in 4H-SiC trenches as a prototype system for infrared sensing. We use a transmission line framework that accounts for the field distribution within the trench, accurately predicting mode frequency and lifetime when compared against finite element method (FEM) electromagnetic calculations. Accounting for the electric field profile across the gap is critical in our model to accurately predict mode frequencies, quality factor (Q factor), and reflectance, outperforming previous circuit models developed in the literature. Beyond structural simulation, our model can provide insights into the frequency ranges in the Reststrahlen band where enhanced sensor activity should be present. The radiative lifetime is significantly enlarged close to the longitudinal optic phonon, restricting sensor efficiency at this wavelength range. This pushes the optimal frequency for sensing closer to the center of the Reststrahlen band than might be naively expected. This model ultimately demonstrates the primary challenge of designing SPhP-based sensors: only a relatively narrow region of the Reststrahlen band offers efficient sensing, guiding future designs for infrared spectroscopy.

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Optical biosensors for diagnosis of COVID-19: nanomaterial-enabled particle strategies for post pandemic era

Tekin,

Kul,

Sagdic

et al. 2024

Microchim Acta

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The COVID-19 pandemic underlines the need for effective strategies for controlling virus spread and ensuring sensitive detection of SARS-CoV-2. This review presents the potential of nanomaterial-enabled optical biosensors for rapid and low-cost detection of SARS-CoV-2 biomarkers, demonstrating a comprehensive analysis including colorimetric, fluorescence, surface-enhanced Raman scattering, and surface plasmon resonance detection methods. Nanomaterials including metal-based nanomaterials, metal–organic frame–based nanoparticles, nanorods, nanoporous materials, nanoshell materials, and magnetic nanoparticles employed in the production of optical biosensors are presented in detail. This review also discusses the detection principles, fabrication methods, nanomaterial synthesis, and their applications for the detection of SARS-CoV-2 in four categories: antibody-based, antigen-based, nucleic acid–based, and aptamer-based biosensors. This critical review includes reports published in the literature between the years 2021 and 2024. In addition, the review offers critical insights into optical nanobiosensors for the diagnosis of COVID-19. The integration of artificial intelligence and machine learning technologies with optical nanomaterial-enabled biosensors is proposed to improve the efficiency of optical diagnostic systems for future pandemic scenarios. Graphical Abstract

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A magnetic control enrichment technique combined with terahertz metamaterial biosensor for detecting SARS-CoV-2 spike protein

Cited by 5 publications

References 52 publications

Advancements and Perspectives in Optical Biosensors

Advancements and Perspectives in Optical Biosensors

Lifetime and Molecular Coupling in Surface Phonon Polariton Resonators

Optical biosensors for diagnosis of COVID-19: nanomaterial-enabled particle strategies for post pandemic era

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