A macrophysiological study of functional organization of the claustrum

Spector, Ilan; Hassmannova, Yarmila; Albé-Fessard, D

doi:10.1016/0014-4886(70)90035-x

Cited by 39 publications

(18 citation statements)

References 15 publications

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“…the striatum and the substantia nigra (ANDERSEN, 1968), the nuclei centralis medius, submedius and reuniens (NAUTA and WHITLOCK, 1954) and locus caeruleus (PICKEL, SEGAL and BLOOM, 1974). Electrophysiologically, SPECTOR, HASSMANNOVA and ALBE- FESSARD (1970) showed that the somatic sensory, auditory and visual projections converge upon the claustrum via multiple and complex pathways, and that the dissimilar responses can be obtained in various portions of the claustrum when sites of stimulation differ. Thus, they concluded that the claustrum is functionally a non-homogeneous multisensory structure, and divided into three subdivisions as anterior, intermediate and posterior.…”

Section: Discussionmentioning

confidence: 99%

Demonstration of Bilateral Claustro-Cortical Connections in the Cat with the Method of Retrograde Axonal Transport of Horseradish Peroxidase

Norita

1977

Arch. Histol. Jap., Arch. Histol. Jpn

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Summary.The claustrum of the cat was studied to determine the extent of its projection to the cerebral cortex.Neurons in the bilateral dorsal claustrum are labeled by retrograde axonal transport of horseradish peroxidase (HRP) from injection sites of different neocortical areas with preponderance to the ipsilateral side. It is revealed that the dorsal claustrum projects to almost entire regions of the bilateral neocortex and that distribution of labeled neurons in the bilateral claustrum has topographical correspondence, rostro-caudal as well as dorso-ventral, with regard to the sites of injections in the neocortex.No neurons in the ventral claustrum are labeled.

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Section: Discussionmentioning

confidence: 99%

Demonstration of Bilateral Claustro-Cortical Connections in the Cat with the Method of Retrograde Axonal Transport of Horseradish Peroxidase

Norita

1977

Arch. Histol. Jap., Arch. Histol. Jpn

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“…In addition, this shape also poses considerable challenges for electrophysiological or microstimulation approaches to this structure. As a consequence, many of the earlier studies on the claustrum were conducted on anesthetized animals, and most were based on the relatively expanded and more accessible dorsal zone of the claustrum in the cat (Segundo and Machne, 1955;Spector et al, 1970Spector et al, , 1974Olson and Graybiel, 1980;LeVay and Sherk, 1981;Sherk and LeVay, 1981;Clarey and Irvine, 1986;Cortimiglia et al, 1991). This not only leaves large portions of this structure unstudied, but also makes extrapolation to alert animals and to the primate brain difficult.…”

Section: Introductionmentioning

confidence: 99%

“…First, anatomical studies revealed afferent connections from various cortical and subcortical sensory structures (Pearson et al, 1982;Tanné-Gariépy et al, 2002;Fernández-Miranda et al, 2008) and reported an apparent topographical mapping of the neocortex onto the claustrum (Pearson et al, 1982;Sherk, 1986;Fernández-Miranda et al, 2008). Second, electrophysiological studies reported claustral neurons that responded to stimuli in the visual, acoustic, and somatic modalities (Segundo and Machne, 1955;Spector et al, 1970Spector et al, , 1974Olson and Graybiel, 1980;LeVay and Sherk, 1981;Sherk and LeVay, 1981;Clarey and Irvine, 1986). In analogy to other brain structures that receive similar diverse sensory afferents and indeed participate in sensory integration, these observations were taken as evidence supporting the integrative function of the claustrum (Sherk, 1986;Ettlinger and Wilson, 1990;Edelstein and Denaro, 2004;Crick and Koch, 2005).…”

Section: Introductionmentioning

confidence: 99%

Unimodal Responses Prevail within the Multisensory Claustrum

2010

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The claustrum receives afferent inputs from multiple sensory-related brain areas, prompting speculation about a role in integrating information across sensory modalities. Here we directly test this hypothesis by probing neurons in the primate claustrum for functional characteristics of multisensory processing. To this end we recorded neuronal responses to naturalistic audio-visual stimuli from the claustra of alert monkeys. Our results reveal the existence of distinct claustral zones comprised of unimodal neurons associated with the auditory and visual modalities. In a visual zone within the ventral claustrum neurons responded to visual stimuli but not to sounds, whereas in an auditory zone located within the central claustrum neurons responded to sounds but not to visual stimuli. Importantly, we find that neurons within either zone are not influenced by stimuli in the other modality and do not exhibit the typical response characteristics usually associated with multisensory processing. While these results confirm the notion of the claustrum as a multisensory structure per se, they argue against the hypothesis of the claustrum serving as an integrator of sensory information.

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“…Although many electro-physiological studies of the claustrum have also been reported (SPECTOR, 1969;SPECTOR, HASSMANNOVA andALBS-FESSARD, 1970, 1974), no conclusive results have been obtained.…”

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confidence: 99%