A macrophage-targeted platform for extending drug dosing with polymer prodrugs for pulmonary infection prophylaxis

Chavas, Thomas E. J.; Su, Fang‐Yi; Srinivasan, Siddarth; Roy, Debashish; Lee, Brian; Lovelace-Macon, Lara; Rerolle, Guilhem F.; Limqueco, Elaine; Skerrett, Shawn J.; Ratner, Daniel M.; West, T. Eoin; Stayton, Patrick S.

doi:10.1016/j.jconrel.2020.11.031

Cited by 12 publications

(6 citation statements)

References 57 publications

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“…Therefore, at the beginning of the disease, health education, strengthening health protection, avoiding spicy and irritating foods, doing oral care, bed rest, and preventing skin and mucous membrane damage are very important. During hospitalization, due to the damage caused by longterm chemotherapy to the body's immunity, it is important to keep the ward clean and disinfected, to treat the child separately from the child with pneumonia, to prevent crossinfection during the diagnosis and treatment of medical staff, and to strictly follow the principle of sterile operation [18]. There are also some shortcomings in this study, where the patients in this study are all from the same hospital, which can lead to some bias in the results.…”

Section: Discussionmentioning

confidence: 99%

Influencing Factors and Coping Strategies of Hospitalization in Children with Leukemia Complicated with Pneumonia

Xiang¹,

Yi²

2022

Computational and Mathematical Methods in Medicine

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Objective. To investigate the influencing factors of pneumonia when pediatric leukemia patients are hospitalized and propose coping strategies. Methods. A retrospective study and analysis of the inpatient medical records of 183 children with leukemia in our hospital from August 2017 to August 2020. A total of 93 cases were in the case group of children with pneumonia, and the rest were 90 cases in the control group. Case data from two groups of children were compared, and the monofactor analysis of pneumonia occurred. The P < 0.05 was selected for its multivariate logistic regression analysis, and its coping strategy was proposed. Results. After multivariate logistic retrospective analysis, it was found that the main influencing factors were neutrophils, white blood cells, vitamin D, and cellular immunity ( P < 0.05 ). A review of the two sets of pathological data found that high doses of cytarabine reduced the incidence of pneumonia in children with leukemia ( P < 0.05 ). Conclusion. A timely understanding of the influencing factors of pediatric diabetes mellitus and pneumonia and the early application of cytarabine can reduce the incidence of pneumonia during the child’s hospitalization.

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Section: Discussionmentioning

confidence: 99%

Influencing Factors and Coping Strategies of Hospitalization in Children with Leukemia Complicated with Pneumonia

Xiang¹,

Yi²

2022

Computational and Mathematical Methods in Medicine

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“…In the context of pulmonary infections, several reports have shown that macrophage-targeted antibiotics or predrugs can increase survival rates in murine pulmonary infection models and also target the intracellular pathogens that reside in AM. Here, in particular Ciprofloxacin and its derivates were exploited to prevent or treat Francisella tularensis infections [75,76] or Burkholderia pseudomallei pulmonary meloidosis [77]. Similar treatment approaches were also evaluated in the context of tuberculosis [132,133].…”

Section: Therapeutic Approaches To Treat Pulmonary Infectionsmentioning

confidence: 99%

Beyond “Big Eaters”: The Versatile Role of Alveolar Macrophages in Health and Disease

Hetzel

Ackermann

Lachmann

2021

IJMS

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Macrophages act as immune scavengers and are important cell types in the homeostasis of various tissues. Given the multiple roles of macrophages, these cells can also be found as tissue resident macrophages tightly integrated into a variety of tissues in which they fulfill crucial and organ-specific functions. The lung harbors at least two macrophage populations: interstitial and alveolar macrophages, which occupy different niches and functions. In this review, we provide the latest insights into the multiple roles of alveolar macrophages while unraveling the distinct factors which can influence the ontogeny and function of these cells. Furthermore, we will highlight pulmonary diseases, which are associated with dysfunctional macrophages, concentrating on congenital diseases as well as pulmonary infections and impairment of immunological pathways. Moreover, we will provide an overview about different treatment approaches targeting macrophage dysfunction. Improved knowledge of the role of macrophages in the onset of pulmonary diseases may provide the basis for new pharmacological and/or cell-based immunotherapies and will extend our understanding to other macrophage-related disorders.

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“…This facilitates drug uptake through binding to mannose receptors, which are highly expressed on AMs (Ref. 88). Using a mouse-adapted infection model of B. thailandensis and a B. pseudomallei clinical isolate, the authors showed that the therapy was significantly more effective than free drug at protecting mice from infection and showed improved pharmacokinetics in AMs.…”

Section: Am-directed Antibioticsmentioning

confidence: 99%

Alveolar macrophages: novel therapeutic targets for respiratory diseases

Lim

Cervantes

Pham

et al. 2021

Expert Rev. Mol. Med.

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Alveolar macrophages (AMs) are lung-resident myeloid cells that sit at the interface of the airway and lung tissue. Under homeostatic conditions, their primary function is to clear debris, dead cells and excess surfactant from the airways. They also serve as innate pulmonary sentinels for respiratory pathogens and environmental airborne particles and as regulators of pulmonary inflammation. However, they have not typically been viewed as primary therapeutic targets for respiratory diseases. Here, we discuss the role of AMs in various lung diseases, explore the potential therapeutic strategies to target these innate cells and weigh the potential risks and challenges of such therapies. Additionally, in the context of the COVID-19 pandemic, we examine the role AMs play in severe disease and the therapeutic strategies that have been harnessed to modulate their function and protect against severe lung damage. There are many novel approaches in development to target AMs, such as inhaled antibiotics, liposomal and microparticle delivery systems, and host-directed therapies, which have the potential to provide critical treatment to patients suffering from severe respiratory diseases, yet there is still much work to be done to fully understand the possible benefits and risks of such approaches.

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A macrophage-targeted platform for extending drug dosing with polymer prodrugs for pulmonary infection prophylaxis

Cited by 12 publications

References 57 publications

Influencing Factors and Coping Strategies of Hospitalization in Children with Leukemia Complicated with Pneumonia

Influencing Factors and Coping Strategies of Hospitalization in Children with Leukemia Complicated with Pneumonia

Beyond “Big Eaters”: The Versatile Role of Alveolar Macrophages in Health and Disease

Alveolar macrophages: novel therapeutic targets for respiratory diseases

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