A Machine‐Learning‐Based Bibliometric Analysis of Cell Membrane‐Coated Nanoparticles in Biomedical Applications over the Past Eleven Years

Abstract

202200206tion is to add polymer materials on the surface of nanoparticles but hard to avoid immune system recognition. [1] Cell membrane encapsulation helps to protect nanoparticles from immune system attack and enhanced targeted ability. Cell membrane biomimetic nanomedicine was first brought up by Zhang et al. in 2011 by coating nanoparticles with an erythrocyte membrane. [2] The nanoparticle's circulation time increased to 40 h in vivo, greatly extending the half-life period, and the red blood cell membrane (RBCM)encapsulated nanoparticles can be used multiple times without irritating an immune response. Since then, cancer cell membranes (CM) were applied to design anticancer vaccination and drug delivery in 2014; [3] platelet membranes (PM) were applied to escape macrophage phagocytosis in 2015; [4] leukocyte membranes as one of the immune cell membranes (IM) were purified to avoid immune system clearance in 2013; [5] T-cell membranes were exploited to target tumor, using their distinct targeting characteristics in 2017, [6,7] and other cell membranes-coated research flourished like bamboo shoots after a spring rain. [8,9] Bibliometric analysis helps scholars to gain an overall view of a complex field quickly including acknowledgment of the main publishing institutions, the most influential scholars, and the most representative research. It was able to assist with developing approaches focused on prognosticating the current and future directions of certain areas. It also structured in a more newfangled display mode, compared with systemic reviews which mainly aim at the content of research produced in a certain field. [10] It offers a global perspective, which can more comprehensively evaluate the phylogeny of a certain field, and provides a basis for the prediction of future research hotspots. [11] Many original articles have been published from 2011 to 2021 in the field of cell membrane-encapsulated nanoparticles research. In this article, we provided an overview and scientific analysis of research about cell membrane-encapsulated nanoparticles via data collected from the Web of Science Core Collection (WoSCC). The analyzed indexes include annual publications and citations, most productive countries, most influential and high-cited authors, and collaborated journals, as well as Cell membrane encapsulation is a growing concept in nanomedicine, for it achieves the purpose of camouflage nanoparticles, realizing the convenience for drug delivery, bio-imaging, and detoxification. Cell membranes are constructed by bilayer lipid phospholipid layers, which have unique properties in cellular uptake mechanism, targeting ability, immunomodulation, and regeneration. Current medical applications of cell membranes include cancers, inflammations, regenerations, and so on. In this article, a general bibliometric overview is conducted of cell membrane-coated nanoparticles covering 11 years of evolution in order to provide researchers in the field with a comprehensive view of the relevant achievements and trends. The authors...