A machine learning‐based approach for improving plasmid DNA production in Escherichia coli fed‐batch fermentations
Zhixian Xu,
Xiaofeng Zhu,
Ali Mohsin
et al.
Abstract:Artificial Intelligence (AI) technology is spearheading a new industrial revolution, which provides ample opportunities for the transformational development of traditional fermentation processes. During plasmid fermentation, traditional subjective process control leads to highly unstable plasmid yields. In this study, a multi‐parameter correlation analysis was first performed to discover a dynamic metabolic balance among the oxygen uptake rate, temperature, and plasmid yield, whilst revealing the heating rate … Show more
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