A macaque connectome for large-scale network simulations in TheVirtualBrain

Shen, Kelly; Bezgin, Gleb; Everling, Stefan; McIntosh, R.

doi:10.1101/480905

Cited by 8 publications

(8 citation statements)

References 68 publications

(77 reference statements)

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“…Details of tractography methods for reconstructing each subject’s structural connectome can be found in Shen et al (2019a , b ). Briefly, FSL’s probtrackx2 was used to perform tractography between all ROIs.…”

Section: Methodsmentioning

confidence: 99%

Virtual Connectomic Datasets in Alzheimer’s Disease and Aging Using Whole-Brain Network Dynamics Modelling

Arbabyazd¹,

Shen

Wang

et al. 2021

eNeuro

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Section: Methodsmentioning

confidence: 99%

Virtual Connectomic Datasets in Alzheimer’s Disease and Aging Using Whole-Brain Network Dynamics Modelling

Arbabyazd¹,

Shen

Wang

et al. 2021

eNeuro

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“…Data from 8 male adult rhesus macaque monkeys ( Macaca mulatta ) were obtained from TheVirtualBrain (Shen et al ., 2019). All surgical and experimental procedures were approved by the Animal Use Subcommittee of the University of Western Ontario Council on Animal Care (AUP no.…”

Section: Methodsmentioning

confidence: 99%

Connectional Asymmetry of the Inferior Parietal Lobule Shapes Hemispheric Specialization in Humans, Chimpanzees, and Rhesus Macaques

Cheng

Zhang

et al. 2021

Preprint

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The inferior parietal lobule (IPL) is one of the most expanded and structurally and functionally asymmetric regions in the human cerebral cortex. Whether the structural and connectional asymmetries of IPL subdivisions differ across primate species and whether this relates to functional asymmetries remain unclear. We identified IPL subregions that exhibited symmetric positive allometric scaling across macaque monkeys, chimpanzees, and humans. Patterns of IPL subregions asymmetry were similar in chimpanzees and humans, whereas no IPL asymmetries were evident in macaques. Among the comparative sample of primates, humans showed the most widespread asymmetric connections in the frontal, parietal, and temporal cortices, constituting leftward asymmetric networks that may provide an anatomical basis for language and tool use. Unique human asymmetric connectivity between the IPL and the primary motor cortex may be related to handedness. These findings suggest that structural and connectional asymmetries may underlie hemispheric specialization of the human brain.

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“…The relationships between structural and functional networks in NHPs is a critical step for developing large-scale neural simulations and informative models of brain function (Shen et al, 2019). Our initial work here on network analyses demonstrates the feasibility of obtaining meaningful structural graphs derived from awake imaging data.…”

Section: Comparisons Of Free-viewing and Structural Networkmentioning

confidence: 98%

Dynamic reconfiguration of macaque brain networks during free-viewing of natural scenes

Ortiz-Rios

Balezeau

Haag

et al. 2021

Preprint

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Natural vision involves the activation of a wide range of higher-level regions processing objects, motion, faces and actions. Here, we pursue a data-driven approach to explore how higher-level visual processes relate to the underlying structural and functional connectivity. Using a free-viewing paradigm in four awake rhesus macaque monkeys, we investigate how different visual scenes changes functional connectivity. Additionally, we explore how such functional connectivity, as measured through fMRI, is related to the structural connectivity, as measured through diffusion weighted imaging. At first, we evaluate the consistency of the elicited free-viewing pattern using standard analytical techniques. We also evaluate the underlying structural connectivity via diffusion data by tracking white matter bundle projections from visual cortex. We then reconstruct free-viewing and structural networks and quantify their properties. Centrality measures over the entire fMRI time-series revealed a consistent functional network engaged during free-viewing that included widespread hub regions across frontal (FEF, 46v), parietal (LIP, Tpt), and occipitotemporal cortex (MT, V4 and TE) among others. Interestingly, a small number of highly-weighted and long-length inter-hemispheric connections indicated the presence of long-range integrative properties during free-viewing. We hypothesized that during free-viewing, networks had the capacity to change their local and distal connections depending on the on-going changes in visual scenes. To capture these network dynamics, we departed from the static modular architecture of the structural networks and demonstrate that hubs in free-viewing networks reorganized according to the presence of objects, motion, and faces in the movie scenes indicating poly-functional properties. Lastly, we compare each NHP subject network and observed high consistency between individuals across same network type with closer correspondence between structural networks (e.g., diffusion based and tract-tracing networks). In summary, our network analyses revealed ongoing changes in large-scale functional organization present during free-viewing in the macaque monkey and highlight the advantages of multi-contrast imaging in awake monkeys for investigating dynamical processes in visual cognition. To further promote the use naturalistic free-viewing paradigms and increase the development of macaque neuroimaging resources, we share our datasets in the PRIME-DE consortium.

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A macaque connectome for large-scale network simulations in TheVirtualBrain

Cited by 8 publications

References 68 publications

Virtual Connectomic Datasets in Alzheimer’s Disease and Aging Using Whole-Brain Network Dynamics Modelling

Virtual Connectomic Datasets in Alzheimer’s Disease and Aging Using Whole-Brain Network Dynamics Modelling

Connectional Asymmetry of the Inferior Parietal Lobule Shapes Hemispheric Specialization in Humans, Chimpanzees, and Rhesus Macaques

Dynamic reconfiguration of macaque brain networks during free-viewing of natural scenes

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